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Application of Centipede Panax notoginseng Extract in Preparation of Medicine for Intestinal Adhesion and Its Medicine

A technology of extract and intestinal adhesion, which is applied in the field of medicinal use of Centipede Panax notoginseng extract and its pharmaceutical composition, to achieve the effect of preventing intestinal adhesion

Inactive Publication Date: 2015-09-09
WUHAN DAO YI TANG PHARMA RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the effect of centipede notoginseng extract on the prevention and treatment of intestinal adhesions

Method used

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  • Application of Centipede Panax notoginseng Extract in Preparation of Medicine for Intestinal Adhesion and Its Medicine
  • Application of Centipede Panax notoginseng Extract in Preparation of Medicine for Intestinal Adhesion and Its Medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1: Preventive effect of centipede Panax notoginseng extract on rat intestinal adhesions

[0016] 1.1 Experimental materials

[0017] 1.1.1 Animals: SD rats, half male and half male, weighing 180-200 g, provided by the Laboratory Animal Center of Huazhong University of Science and Technology, license number: SCXK (E) 2010-0009.

[0018] 1.1.2 Drugs:

[0019] The medicine of the present invention, the extract of Panax notoginseng (total saponin content is about 60%), is prepared by conventional water decoction method. , filter, combine the filtrates, concentrate the filtrate into a liquid with a relative density of 1.04-1.1 at 60°C, let it cool, add ethanol to make the alcohol-containing capacity 40-80%, stir well, let stand for 12 hours, filter, and recover the ethanol, Volatilize until there is no alcohol smell, get the extract, add water to dissolve, clarify, put on a non-polar or weakly polar macroporous adsorption resin column, wash with water, discard, and...

Embodiment 2

[0040] Example 2: Centipede Panax notoginseng extract prevents postoperative intestinal adhesion in 30 cases

[0041] 2.1 Experimental materials

[0042] 2.1.1 Medicine: the medicine of the present invention, centipede notoginseng extract, prepared by conventional decoction method, the total saponin content is about 60%, the centipede notoginseng extract powder and micropowder silica gel (accounting for about 0.4% of the total) are evenly mixed, 60-mesh sieve, and encapsulated, namely centipede Panax notoginseng extract capsules.

[0043] 2.1.2 Objects: 60 cases of various abdominal operations were selected and randomly divided into the administration group and the control group with 30 cases in each. There was no significant difference in the general conditions of the two groups, and they were comparable.

[0044] 2.2 Treatment methods

[0045] 2.2.1 Dosing regimen

[0046] At 12 hours after operation, the administration group was given Oral centipede notoginseng extract c...

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Abstract

The application relates to an application of a centipede pseudo-ginseng extract product in the preparation of a medicine against intestinal adhesion and a medicine thereof. The application discloses an application of a centipede pseudo-ginseng extract product in the preparation of a medicine for preventing or treating intestinal adhesion and a pharmaceutical composition thereof. The centipede pseudo-ginseng extract product contains centipede Panax Notoginseng Saponins. The centipede pseudo-ginseng extract product is prepared by a water decoction method. It proves through pharmacological testing and clinical tests that the centipede pseudo-ginseng extract product has a good effect of preventing intestinal adhesion and has high-efficiency and low-toxicity advantages.

Description

technical field [0001] The present invention relates to the medicinal use of centipede notoginseng extract and its medicinal composition. Background technique [0002] Intestinal adhesions are a common complication after abdominal and pelvic surgery. According to reports, the proportion of intestinal adhesions of varying degrees after abdominal surgery is as high as 80-90%. Studies have shown that intestinal adhesions are related to the inflammatory exudation of the abdominal cavity and the weakening of intestinal peristalsis. The inflammatory response leads to inflammatory exudation, fibrin deposition, and then the deposition is transformed into fibrinous tissue to form adhesions. Adhesion is a repair response of the body's immune system to damaged and ischemic tissue, but excessive adhesion can lead to a serious complication - intestinal obstruction. Therefore, the development of high-efficiency and low-toxicity new drugs for the prevention and treatment of intestinal adh...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/71A61P1/00A61P29/00A61P37/02
Inventor 廖一帆江哲遒邴飞虹
Owner WUHAN DAO YI TANG PHARMA RES INST
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