Ligustrazine microcapsule and preparation method

A technology of ligustrazine and ligustrazine alkali salt, which is applied in the field of medicine, can solve the problems of unhelpful experimental research, non-biodegradable excipients, and different uses, and achieve the effect of sufficient raw materials in the market, prevention and treatment of intestinal adhesions, and prevention of intestinal adhesions

Inactive Publication Date: 2006-08-30
凌立君
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The products of the above two invention patents all belong to oral medicines, and not only the dosage forms are different from the intraperitoneal and intraperitoneal slow-release agents that the applicant of this patent intends to develop experimentally, but also the purposes are completely different. The auxiliary materials used (such as hydroxypropyl methylcellulose, ethyl Cellulose) cannot be biodegraded in the abdominal cavity, so it is not helpful to the experimental research of the applicant of this patent

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The present embodiment prepares ligustrazine hydrochloride 20%, chitosan 15%, paraffin 40%, as emulsifier Span-80 2.5%, Tween-80 10%, the distilled water of above component total weight 12.5% ​​by weight percentage , prepare ligustrazine microcapsules according to the following method:

[0025] (1) under room temperature conditions, ligustrazine hydrochloride is dissolved in distilled water;

[0026] (2) Add liquid paraffin, and add Span-80, stir to form a water-in-oil emulsion (W / O);

[0027] (3) Add chitosan solution again, and add Tween-80 and stir to form a water-in-oil-in-water multiple emulsion (W / O / W);

[0028] (4) Use the complex emulsion as the injection liquid, the liquid surface distance is 2.5-3cm, the injection speed is 80mm / h (10ml / h, controlled at 5-15ml / h), the stirring speed is 150r / min, and the electrostatic field voltage is 2.2KV respectively Apply between the sharp hole and the solidification solution through two electrodes, add 4mol / L sodium hydro...

Embodiment 2

[0042] The present embodiment prepares ligustrazine phosphate 5%, chitosan 7.5%, paraffin 62.5%, as emulsifier Span-80 5%, Tween-80 10%, total weight 10% distilled water by weight percentage, according to the following Method for preparing ligustrazine microcapsules:

[0043] (1) at room temperature, ligustrazine phosphate is dissolved in distilled water;

[0044] (2) Add liquid paraffin, and add Span-80, stir to form a water-in-oil emulsion (W / O);

[0045](3) Add chitosan solution and stir with Tween-80 to form water-in-oil-in-water multiple emulsion (W / O / W)

[0046] (4) The complex emulsion is used as the injection liquid, the liquid surface distance is 2.5-3cm, the injection speed is 80mm / h (10ml / h, controlled at 5-15ml / h), the stirring speed is 150r / min, and the electrostatic field voltage is 2.2KV, Add 5mol / L potassium hydroxide solidified solution into the injection to form ligustrazine phosphate microcapsules with a particle size of 300um-800um and a multi-vesicle str...

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PUM

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Abstract

A ligustraznie microsoftgel for preventing the adhesive intestinal infarction after operation is prepared from alkaline salt of ligustrazine, chitosan, paraffine wax and emulsifier proportionally through high-voltage electrostatic method.

Description

technical field [0001] The invention relates to a medicinal microcapsule, especially a ligustrazine microcapsule for preventing postoperative adhesive ileus, and also relates to a preparation method thereof, which belongs to the technical field of medicine. Background technique [0002] Abdominal adhesion is an inevitable process of postoperative peritoneal repair. If there is no adhesion, there is no repair, but when the repair is disordered or the fiber degradation is incomplete so that it becomes punctate, angled, or cord-like adhesions, it will become the pathogenesis of mechanical intestinal obstruction. About 90% of abdominal surgery has adhesions , More than about 40% will cause adhesive intestinal obstruction. [0003] In order to prevent and treat adhesive ileus, at present, the improvement of surgical techniques, reduction of fibrous deposition, promotion of fibrinolysis, use of barrier substances, and combination of drugs are mainly carried out. There are disadv...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4965A61K9/16A61P41/00
Inventor 凌立君潘立群曾莉贾晓斌魏惠华
Owner 凌立君
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