A composition for bladder lavage
A composition and a technique for lavage, which are applied in the field of bladder lavage compositions and their preparation, can solve the problems of complicated treatment methods, complicated operations and high costs for cystitis, and achieve the effect of enhancing the adhesion of bladder mucosa
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Embodiment 1
[0054] Preparation Scheme 1 of Bladder Lavage Combination Preparation
[0055] (1) Add 1000ml of water for injection, 0.375g of sodium dihydrogen phosphate, 0.29g of disodium hydrogen phosphate, and 8.75g of sodium chloride into the preparation container. sterilizing and filtering at 121°C for 30 minutes to obtain phosphate buffer;
[0056] (2) After the above solution is cooled, add 0.15g of hyaluronic acid sterilized dry powder and 0.25g of chitosan sterilized dry powder into the phosphate buffer solution and seal it in a clean environment of class 100. completely dissolved;
[0057] (3) Filling under aseptic conditions to obtain a bladder lavage combination product containing hyaluronic acid and chitosan.
[0058] The test results of the bladder lavage combination preparation prepared by the above method are: the pH value is 6.6, the light transmittance is 100%, and the osmotic pressure is 293mOsmol L -1 , the dynamic viscosity is 289Pa·s, the protein content is 0%, the ...
Embodiment 2
[0060] Preparation scheme two of bladder lavage combination preparation
[0061] (1) Add 1000ml of water for injection, 0.854g of sodium dihydrogen phosphate, 0.315g of disodium hydrogen phosphate and 3.20g of sodium chloride into the preparation container. Sterilize and filter, then place in a high-pressure steam sterilizer, and sterilize at 121°C for 30 minutes to obtain a phosphate buffer;
[0062] (2) After the above solution is cooled, add 0.8g of hyaluronic acid sterilized dry powder and 0.55g of chitosan sterilized dry powder into the phosphate buffer solution and seal it in a class 100 clean environment. completely dissolved;
[0063] (3) Filling under aseptic conditions to obtain a bladder lavage combination product containing hyaluronic acid and chitosan.
[0064] The detection results of the bladder lavage combination preparation prepared by the above method are: the pH value is 6.5, the light transmittance is 99.8%, and the osmotic pressure is 299mOsmol L -1 , t...
Embodiment 3
[0066] Preparation scheme three of bladder lavage combination preparation
[0067] (1) Add 1000ml of water for injection, 0.715g of sodium dihydrogen phosphate, 0.342g of disodium hydrogen phosphate and 2.0g of sodium chloride into the preparation container. Sterilize and filter, then place in a high-pressure steam sterilizer, and sterilize at 121°C for 30 minutes to obtain a phosphate buffer;
[0068] (2) After the above solution is cooled, add 0.5 g of hyaluronic acid sterilized dry powder and 1.0 g of chitosan sterilized dry powder into the phosphate buffer solution and seal it in a class 100 clean environment. completely dissolved;
[0069] (3) Filling under aseptic conditions to obtain a bladder lavage combination product containing hyaluronic acid and chitosan.
[0070] The test results of the bladder lavage combination preparation prepared by the above method are: the pH value is 6.5, the light transmittance is 100%, and the osmotic pressure is 305mOsmol L -1 , the d...
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