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Combination used for bladder irrigation

A composition and lavage technology, which are applied in the field of bladder lavage composition and its preparation, can solve the problems of complicated cystitis treatment methods, ineffective hemostatic drugs, and high cost, and achieve the effect of enhancing bladder mucosal adhesion

Active Publication Date: 2014-03-26
上海建华精细生物制品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The treatment of hemorrhagic and radiation cystitis is complicated, and the effect of systemic and local hemostatic drugs is not obvious. The total effective rate of hyperbaric oxygen chamber treatment can reach 74%, and some of them need electrocoagulation to control the bleeding rate. The operation is complicated and the cost is high.

Method used

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  • Combination used for bladder irrigation

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Preparation Scheme 1 of Bladder Lavage Combination Preparation

[0055] (1) Add 1000ml of water for injection, 0.375g of sodium dihydrogen phosphate, 0.29g of disodium hydrogen phosphate, and 8.75g of sodium chloride into the preparation container. sterilizing and filtering at 121°C for 30 minutes to obtain phosphate buffer;

[0056] (2) After the above solution is cooled, add 0.15g of hyaluronic acid sterilized dry powder and 0.25g of chitosan sterilized dry powder into the phosphate buffer solution and seal it in a clean environment of class 100. completely dissolved;

[0057] (3) Filling under aseptic conditions to obtain a bladder lavage combination product containing hyaluronic acid and chitosan.

[0058] The test results of the bladder lavage combination preparation prepared by the above method are: the pH value is 6.6, the light transmittance is 100%, and the osmotic pressure is 293mOsmol L -1 , the dynamic viscosity is 289Pa·s, the protein content is 0%, the ...

Embodiment 2

[0060] Preparation scheme two of bladder lavage combination preparation

[0061] (1) Add 1000ml of water for injection, 0.854g of sodium dihydrogen phosphate, 0.315g of disodium hydrogen phosphate and 3.20g of sodium chloride into the preparation container. Sterilize and filter, then place in a high-pressure steam sterilizer, and sterilize at 121°C for 30 minutes to obtain a phosphate buffer;

[0062] (2) After the above solution is cooled, add 0.8g of hyaluronic acid sterilized dry powder and 0.55g of chitosan sterilized dry powder into the phosphate buffer solution and seal it in a class 100 clean environment. completely dissolved;

[0063] (3) Filling under aseptic conditions to obtain a bladder lavage combination product containing hyaluronic acid and chitosan.

[0064] The detection results of the bladder lavage combination preparation prepared by the above method are: the pH value is 6.5, the light transmittance is 99.8%, and the osmotic pressure is 299mOsmol L -1 , t...

Embodiment 3

[0066] Preparation scheme three of bladder lavage combination preparation

[0067] (1) Add 1000ml of water for injection, 0.715g of sodium dihydrogen phosphate, 0.342g of disodium hydrogen phosphate and 2.0g of sodium chloride into the preparation container. Sterilize and filter, then place in a high-pressure steam sterilizer, and sterilize at 121°C for 30 minutes to obtain a phosphate buffer;

[0068] (2) After the above solution is cooled, add 0.5 g of hyaluronic acid sterilized dry powder and 1.0 g of chitosan sterilized dry powder into the phosphate buffer solution and seal it in a class 100 clean environment. completely dissolved;

[0069] (3) Filling under aseptic conditions to obtain a bladder lavage combination product containing hyaluronic acid and chitosan.

[0070] The test results of the bladder lavage combination preparation prepared by the above method are: the pH value is 6.5, the light transmittance is 100%, and the osmotic pressure is 305mOsmol L -1 , the d...

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Abstract

The invention discloses a combination for bladder irrigation. In the total volume, the combination contains the following necessary components: 0.01-0.1 w / v % of hyaluronic acid, 0.005 to 0.2 w / v % of chitosan and allowance of phosphate buffer.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a composition for bladder lavage and a preparation method thereof. Background technique [0002] Since the 1970s, some scholars have put forward the bladder barrier theory, which believes that the tight junctions between the epithelial cells of the bladder mucosa and special umbrella cells help to block the action of bacteria, certain molecules and ions. A layer of glucosaminoglycan (GAG) is distributed on the surface of the lamina propria of the bladder mucosa, which can prevent the adhesion of harmful factors to the bladder mucosa and protect the bladder mucosa from damage. When the GAG ​​layer is damaged, irritants in the urine can penetrate the epithelial tissue of the bladder, which causes immediate pain and at the same time the beginning of a degenerative process, damage to this protective barrier can also increase the development of infection and tumor lesions r...

Claims

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Application Information

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IPC IPC(8): A61K31/728A61P13/10A61K31/722
Inventor 黄慧娟徐雯沈唯樑吕忠辉孔淑静任彩霞魏欣侯永泰吴剑英
Owner 上海建华精细生物制品有限公司
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