Nano-silver anti-infection hernia repair patch and preparation method thereof

A technology for hernia repair and nano-silver, applied in the field of nano-silver anti-infective hernia repair patch and its preparation, can solve the problems of large surface area, poor stability, high activity, etc., achieve stable performance, good antibacterial effect, and prevent infection Effect

Inactive Publication Date: 2014-07-02
刘文博
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the size of nano-silver particles is nanoscale, with large surface area, high activity and poor stability.

Method used

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  • Nano-silver anti-infection hernia repair patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Prepare the anti-infective hernia repair sheet containing nano silver according to the following method:

[0025] (1) Preparation of polymer solution

[0026] Take PLC and MPEG-PDLLA and weigh them, mix them at a mass ratio of 9:1, and place them in a container; calculate the amount of acetone at a concentration of 0.1g / ml, and add a certain amount of acetone to the container; place the container at 30°C , fully dissolved, and shaken at intervals. After the polymer is completely dissolved, seal it for later use.

[0027] (2) Mixing nano-silver suspension and polymer solution

[0028] Measure 20mL of high molecular polymer solution and place it in a container, measure nano silver solution with a volume ratio of nano silver solution (10mg / mL) and high molecular polymer solution of 1:10, and slowly add the measured nano silver solution to the continuous In the shaken high molecular polymer solution, fully shake and shake to form a uniform dispersion;

[0029] (3) Prepar...

Embodiment 2

[0032] (1) Preparation of polymer solution

[0033] Take the PLC and place it in a container, calculate the amount of acetone with a concentration of 0.1g / ml, and add a certain amount of acetone to the container; place the container at 30°C, fully dissolve, shake at intervals, and seal it for later use after the PLC is completely dissolved ;

[0034] (2) Mixing nano-silver suspension and polymer solution

[0035] Measure 20mL of the matrix solution and place it in a container, measure the nano-silver solution at a volume ratio of 1:10 between the nano-silver solution (10mg / mL) and the polymer solution, and slowly add the measured nano-silver solution to the continuously shaking and oscillating In the high molecular polymer solution, fully shake and shake to form a uniform dispersion;

[0036] (3) Preparation of Hernia Repair Sheets Loaded with Nanosilver

[0037] The hernia repair sheet (10cm×10cm) was placed in a polytetrafluoroethylene-coated mold, and the sufficiently sh...

Embodiment 3

[0039] (1) Preparation of polymer solution

[0040] Take PLC and MPEG-PDLLA and weigh them, mix them at a mass ratio of 5:5, and place them in a container; calculate the amount of acetone at a concentration of 0.1g / ml, and add a certain amount of acetone to the container; place the container at 30°C , fully dissolved, and shaken at intervals. After the polymer is completely dissolved, seal it for later use.

[0041] (2) Mixing nano-silver suspension and polymer solution

[0042] Measure 40mL of high molecular polymer solution and put it in the container, measure the nano silver solution with the volume ratio of nano silver solution (5mg / mL) and high molecular polymer solution 1:9, slowly add the measured nano silver solution to the continuous In the shaken high molecular polymer solution, fully shake and shake to form a uniform dispersion;

[0043] (3) Preparation of Hernia Repair Sheets Loaded with Nanosilver

[0044]The hernia repair sheet (10cm×15cm) was placed in a poly...

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Abstract

The invention relates to a nano-silver anti-infection hernia repair patch. The nano-silver anti-infection hernia repair patch comprises a hernia repair patch base material, wherein nano-silver stabilized by a high-molecular polymer is immobilized on the surface of the hernia repair patch base material. The hernia repair patch disclosed by the invention is excellent in antibacterial performance and spectrum antibacterial performance, and free from medicine resistance. By using the hernia repair patch disclosed by the invention for treating hernia, antibiotics do not need to be used for the whole body of the patient to prevent infection.

Description

technical field [0001] The invention belongs to the technical field of external medical materials, more specifically, the invention relates to an anti-infection hernia repair sheet containing nano-silver and a preparation method thereof. Background technique [0002] Tension-free hernia repair is the mainstream operation for the treatment of hernia at present. It has been widely carried out in large and medium-sized hospitals in China, and many patients have benefited from it. However, secondary infection of the mesh implanted in the body has always been the most troublesome problem for surgeons. Mesh infection is also the most serious complication of patients after tension-free herniorrhaphy, which increases the suffering of patients, prolongs the hospital stay, and seriously affects patient's quality of life. At the same time, after severe mesh infection occurs, the mesh usually needs to be removed, which leads to the failure of the operation and also brings difficulties ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/34C08J7/04
Inventor 刘文博
Owner 刘文博
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