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Use of ferulic acid in preparation of drug for resisting mammal anxiety

A technology of mammals and ferulic acid, which is applied in the direction of drug combinations and nervous system diseases, can solve problems such as fatigue, lethargy, and muscle relaxation, and achieve significant anti-anxiety effects and good development and application prospects

Inactive Publication Date: 2014-10-08
BEIJING UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The advantages of this type of drug are quick effect and low price, but they have side effects such as sedative hypnosis and muscle relaxation, which can easily lead to adverse reactions such as fatigue and drowsiness.
Although some new anti-anxiety drugs such as buspirone do not have the above-mentioned side effects, they have side effects such as dizziness, headache, nervousness, excitement, nausea, and tachycardia

Method used

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  • Use of ferulic acid in preparation of drug for resisting mammal anxiety
  • Use of ferulic acid in preparation of drug for resisting mammal anxiety
  • Use of ferulic acid in preparation of drug for resisting mammal anxiety

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Embodiment Construction

[0006] Specific embodiments are provided below to further explain the present invention, but do not imply any limitation to the present invention.

[0007] The invention provides the use of ferulic acid in preparing anti-anxiety drugs, thereby providing a new anti-anxiety drug with good curative effect and less side effects. Among them, ferulic acid is an active ingredient for preparing anti-anxiety drugs. The medicament according to the present invention can be used for the treatment of anxiety in mammals. Such mammals are known to those of skill in the art, and exemplary mammals include humans, primates, bovines, porcines, canines, felines, and rodents (eg, mice and rats).

[0008] The chemical name of ferulic acid is 4-hydroxy-3-methoxycinnamic acid, which is one of the derivatives of cinnamic acid (also known as cinnamic acid). Ferulic acid can be absorbed by the human body, and can be excreted in urine in time. It has extremely low toxicity, is relatively safe to use, a...

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Abstract

The invention provides a use of ferulic acid in preparation of a drug for resisting mammal anxiety and provides a novel antianxiety drug having good effects and small side effects. Ferulic acid is an effective component of the antianxiety drug. Results of mouse elevated plus-maze test, hole-board test and spontaneous activity test on ferulic acid shows that ferulic acid has substantial antianxiety effects and no calmness effect and thus adverse reactions such as fatigue and somnolence caused by calmness effects of the existing antianxiety drug are avoided.

Description

technical field [0001] The invention relates to the new medicinal field of ferulic acid, more specifically to the new application of ferulic acid in the preparation of anxiolytic drugs for mammals. Background technique [0002] Anxiety is a complex emotional reaction formed by the interweaving of feelings of tension, anxiety, worry, worry and fear. When the severity of anxiety is significantly inconsistent with objective events or situations, or if it persists for too long, it becomes pathological anxiety, which is called anxiety symptoms. If the relevant diagnostic criteria are met, it can be diagnosed as anxiety disorder. Anxiety disorder, also known as anxiety neurosis, is characterized by generalized anxiety disorder (chronic anxiety disorder) and paroxysmal panic state (acute anxiety disorder) as the main clinical manifestations, often accompanied by dizziness, chest tightness, palpitations, tremors and restlessness in movement, etc. symptom. Anxiety disorders serious...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61P25/22
Inventor 黄建梅李贵云王小红于素云付茜
Owner BEIJING UNIV OF CHINESE MEDICINE
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