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A kind of medicine for resolving phlegm and relieving cough and preparation method thereof

A technology for resolving phlegm, relieving cough, and medicine, which is applied in the direction of medicine combination, medicine delivery, and medicine formula. Quick cough and expectorant effect

Active Publication Date: 2019-03-01
湖北凤凰白云山药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Most of these drugs on the market use ambroxol as the active ingredient, and some use dextromethorphan hydrobromide as the main ingredient, but they cannot relieve cough and expectorant at the same time
The disintegration time of ordinary tablets of ambroxol hydrochloride on the market is relatively long, and children and the elderly have difficulty swallowing. It is inconvenient for patients to take it, and the compliance is poor, which affects the therapeutic effect of ambroxol hydrochloride. The performance of the injection is unstable during storage. The increase of related substances will have a certain impact on the quality and safety of the drug; and in the process of medication, because the low pH will cause discomfort to the human body, the use of stabilizers will increase the production process and increase the production cost.

Method used

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  • A kind of medicine for resolving phlegm and relieving cough and preparation method thereof
  • A kind of medicine for resolving phlegm and relieving cough and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A medicine for reducing phlegm and relieving cough consists of the following components: 1.5kg of ambroxol hydrochloride, 1.13kg of dextromethorphan hydrobromide, 550kg of sucrose, 0.1kg of citric acid, 0.9kg of methylparaben, and 0.1kg of propylparaben kg, menthol 0.08kg, apple essence 300ml, ethanol 1000ml, disodium hydrogen phosphate 0.5kg.

[0031] Preparation:

[0032] 1. Take sucrose and appropriate amount of pure water to heat and miscible to make simple syrup;

[0033] 2. Dissolve ambroxol hydrochloride, citric acid, and disodium hydrogen phosphate with pure water to make ambroxol hydrochloride aqueous solution;

[0034] 3. Add dextromethorphan hydrobromide, methylparaben, propylparaben, and menthol to ethanol to dissolve, then add hot water and stir until clear and transparent to make an aqueous solution of dextromethorphan hydrobromide;

[0035] 4. Stir and mix ambroxol hydrochloride aqueous solution, dextromethorphan hydrobromide aqueous solution and simple...

Embodiment 2

[0037] A medicine for reducing phlegm and relieving cough consists of the following components: 1.8kg of ambroxol hydrochloride, 1.2kg of dextromethorphan hydrobromide, 550kg of sucrose, 0.06kg of citric acid, 0.9kg of methylparaben, and 0.1kg of propylparaben kg, menthol 0.07kg, apple essence 300ml, ethanol 1000ml, disodium hydrogen phosphate 0.5kg.

[0038] Preparation:

[0039] 1. Take sucrose and appropriate amount of pure water to heat and miscible to make simple syrup;

[0040] 2. Dissolve ambroxol hydrochloride, citric acid, and disodium hydrogen phosphate with pure water to make ambroxol hydrochloride aqueous solution;

[0041] 3. Add dextromethorphan hydrobromide, methylparaben, propylparaben, and menthol to ethanol to dissolve, then add hot water and stir until clear and transparent to make an aqueous solution of dextromethorphan hydrobromide;

[0042] 4. Stir and mix ambroxol hydrochloride aqueous solution, dextromethorphan hydrobromide aqueous solution and simple...

Embodiment 3

[0044] A medicine for reducing phlegm and relieving cough is composed of the following components: 1.2kg of ambroxol hydrochloride, 1.2kg of dextromethorphan hydrobromide, 550kg of sucrose, 0.08kg of citric acid, 0.9kg of methylparaben, and 0.1kg of propylparaben kg, menthol 0.1kg, apple essence 300ml, ethanol 1000ml, disodium hydrogen phosphate 0.6kg.

[0045] Preparation:

[0046] 1. Take sucrose and appropriate amount of pure water to heat and miscible to make simple syrup;

[0047] 2. Dissolve ambroxol hydrochloride, citric acid, and disodium hydrogen phosphate with pure water to make ambroxol hydrochloride aqueous solution;

[0048] 3. Add dextromethorphan hydrobromide, methylparaben, propylparaben, and menthol to ethanol to dissolve, then add hot water and stir until clear and transparent to make an aqueous solution of dextromethorphan hydrobromide;

[0049] 4. Stir and mix ambroxol hydrochloride aqueous solution, dextromethorphan hydrobromide aqueous solution and simp...

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PUM

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Abstract

The invention discloses medicine for resolving phlegm and relieving cough. The medicine is characterized by being prepared from the ingredients in parts by weight: 1-2 parts of ambroxol hydrochloride, 0.8-1.5 parts of dextromethorphan hydrobromide, 0.05-0.2 part of citric acid, 0.05-0.12 part of menthol and 0.1-0.8 part of disodium hydrogen phosphate. According to the medicine, the effects of relieving cough and dispelling phlegm can be exerted in a more effective and more rapid manner.

Description

technical field [0001] The invention relates to the field of preparations, in particular to a medicine for reducing phlegm and relieving cough and a preparation method thereof Background technique [0002] Cough with sputum is a very common disease, and chronic bronchitis is chronic non-specific inflammation of the trachea, bronchial mucosa and surrounding tissues. Clinically, cough and sputum are the main symptoms, and the onset lasts for 3 months every year for 2 or more consecutive years. Slow onset, long course, repeated acute attacks and exacerbations. The main symptoms are cough, expectoration, or accompanied by wheezing. Acute exacerbation refers to the sudden aggravation of symptoms such as cough, sputum, and wheezing. The main cause of acute exacerbation is respiratory tract infection, and pathogens can be viruses, bacteria, mycoplasma and chlamydia, etc. [0003] The clinical manifestations are: slow onset, long course of disease, repeated acute attacks and exa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/42A61K9/00A61P11/10A61P11/14A61K31/137A61K31/485A61K31/194A61K31/045
CPCA61K9/0095A61K31/045A61K31/137A61K31/194A61K31/485A61K33/42A61K47/14A61K47/26A61K2300/00
Inventor 程雪翔
Owner 湖北凤凰白云山药业有限公司
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