Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A platelet preservation solution

A technology of preservation solution and platelets, applied in the field of biomedicine, can solve problems such as difficult to control bacterial contamination, easy loss of hemostatic function of platelets, septic shock, etc.

Active Publication Date: 2015-12-09
JIANGYIN LIBO MEDICINE BIOTECH
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Platelets stored at room temperature tend to lose their hemostatic function, and the room temperature is relatively high, making it difficult to control bacterial contamination. Septic shock caused by transfusion of bacterially contaminated platelets has always been a serious clinical problem

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A platelet preservation solution
  • A platelet preservation solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The preparation method of this platelet preservation solution is:

[0015] Dimethyl sulfoxide (DMSO) and fresh water for injection are prepared into a solution with a volume concentration of 50%, then stirred evenly, and medicinal charcoal is added; then the resulting solution is decarburized by filtration through a titanium rod, and then passed through a 0.45um micropore Filter through a filter membrane, and then filter through a 0.22um microporous membrane to obtain the platelet preservation solution. The dosage of medicinal charcoal is to add 2g of medicinal charcoal to every 1000ml platelet preservation solution.

Embodiment 2

[0017] The preparation method of this platelet preservation solution is:

[0018] Dimethyl sulfoxide (DMSO) and fresh water for injection are prepared into a solution with a volume concentration of 85%, then stirred evenly, and medicinal charcoal is added; then the obtained solution is decarburized by filtration through a titanium rod, and then passed through a 0.45um micropore Filter through a filter membrane, and then filter through a 0.22um microporous membrane to obtain the platelet preservation solution. Wherein the amount of medicinal charcoal is to add 10g of medicinal charcoal to every 1000ml of platelet preservation solution.

Embodiment 3

[0020] The platelet preservation solution obtained in Example 1 was stored at -14°C for 3 hours, then at 14°C for 3 hours, and this cycle was repeated once, and finally stored at room temperature.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides blood platelet preserving fluid. A preparation method of the blood platelet preserving fluid comprises the following steps: preparing dimethyl sulfoxide, namely DMSO and fresh injection water into a solution with the volume concentration of 100%-50%; agitating uniformly and adding medical carbon; decarbonizing the obtained solution by a titanium rod and filtering the solution by a 0.45-micron micro-pore filter membrane; and filtering by a 0.22-micron micro-pore filter membrane to obtain the blood platelet preserving fluid. The preserving fluid can keep the physiological functions of blood platelets at a low temperature and has no toxic and side effects; and the damages of a receptor can be controlled in the lowest range.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a preservation solution for low-temperature preservation of platelets in vitro. Background technique [0002] Platelets are an important component of blood, participate in the coagulation process of the body, play a normal hemostatic function, and prevent blood loss after injury; at the same time, platelets also participate in inflammation, immunity and support for endothelial integrity. When platelets are stored at 4°C, the activity decreases rapidly, about 40% activity after 6 hours, and only 20% activity after 12 hours. Platelets stored at room temperature tend to lose their hemostatic function, and the room temperature is relatively high, making it difficult to control bacterial contamination. Septic shock caused by transfusion of bacterially contaminated platelets has always been a serious clinical problem. How to protect the activity of platelets, improve their survival rate in ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A01N1/02
Inventor 王布强刘丹
Owner JIANGYIN LIBO MEDICINE BIOTECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com