Application of protocatechualdehyde to preparation of drug for treating or preventing pulmonary fibrosis
A technique for pulmonary fibrosis and protocatechuic aldehyde, applied in drug combinations, pharmaceutical formulations, active ingredients of aldehydes, etc., can solve problems such as unreported pharmacological effects
Inactive Publication Date: 2015-01-14
BINZHOU MEDICAL COLLEGE
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Problems solved by technology
[0003] Protocatechuic aldehyde is a water-soluble active ingredient of the traditional Chinese medicine Salvia miltiorrhiza, but the pharmacological effects of protocatechuic aldehyde in the preparation of prevention or treatment of pulmonary fibrosis have not been reported
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Embodiment 1
[0009] Embodiment 1 preparation of protocatechuic aldehyde tablet
[0010] Weigh 100.0g protocatechualdehyde, 35.0g powdered sugar, 40.0g lactose and 23.0g sodium carboxymethyl starch, mix well and pass through a 100-mesh sieve, add an appropriate amount of 3% PVP K30 Appropriate amount of water solution to make soft material, granulate with 20-mesh sieve, dry at 60°C for 3 hours, granulate with 18-mesh sieve, add 2.0g of magnesium stearate, mix evenly, punch with shallow concave, and adjust the tablet weight to about 200mg.
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The invention provides a novel application of protocatechualdehyde as a drug and particularly relates to an application of protocatechualdehyde to pulmonary fibrosis prevention or treatment realized by inhibiting epithelial intercellular substance conversion and fibroblast proliferation and further inhibiting the occurrence and development of pulmonary fibrosis. According to the application, the dosage range of protocatechualdehyde is 20-2000mg and preferably 20-1000mg.
Description
technical field [0001] The present invention relates to protocatechualdehyde inhibiting the occurrence and development of pulmonary fibrosis so as to prevent or treat pulmonary fibrosis; specifically, it relates to protocatechualdehyde inhibiting pulmonary fibrosis by inhibiting epithelial-mesenchymal transition (EMT) and inhibiting abnormal activation of pulmonary fibroblasts. The occurrence and development of fibrosis can prevent or treat pulmonary fibrosis. Background technique: [0002] Idiopathic pulmonary fibrosis (IPF), also known as cryptogenic fibrosing alveolitis (CFA), is a chronic inflammatory interstitial disease. (usual interstitialpneumonia, UIP) is a characteristic pathological change with unknown etiology. The main manifestations are that the appearance of fibroblastic foci leads to the deposition of a large amount of extracellular matrix (ECM), the accumulation of collagen, and the destruction of alveolar structure, which eventually leads to the destructio...
Claims
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IPC IPC(8): A61K31/11A61P11/00
CPCA61K31/11A61K2300/00
Inventor 蒋王林吕长俊栾海云亢泽春刁慧玲
Owner BINZHOU MEDICAL COLLEGE
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