Orally rapidly disintegrating tablet of garlic oil and preparation method thereof
A technology for oral fast disintegrating tablets and garlic oil, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc. and tissue damage, to achieve the effects of low cost, increased stability, and increased adaptability
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Embodiment 1
[0019] The formula of the oral fast-disintegrating tablet of garlic oil is as follows:
[0020]
[0021] To prepare, follow these steps:
[0022] 1) Preparation of β-cyclodextrin inclusion compound of garlic oil: According to the formula ratio, add 5 times the amount of water to the β-cyclodextrin and grind it thoroughly, then add garlic oil and mix well in a colloid mill, Grind into a paste, refrigerate at 4°C for 24 hours, wash with ethanol, and dry under reduced pressure at 40°C for 1 hour to obtain the clathrate;
[0023] 2) Preparation of garlic oil orally disintegrating tablets: Weigh the β-cyclodextrin inclusion compound of garlic oil and other components according to the formula ratio, mix thoroughly, pass through a 100-mesh sieve, put the mixed powder into a tablet machine and directly Tablet.
Embodiment 2
[0025] The formula of the oral fast-disintegrating tablet of garlic oil is as follows:
[0026]
[0027] To prepare, follow these steps:
[0028] 1) Preparation of β-cyclodextrin inclusion compound of garlic oil: According to the formula ratio, add 5 times the amount of water to the β-cyclodextrin and grind it thoroughly, then add garlic oil and mix well in a colloid mill, Grind into a paste, refrigerate at 4°C for 24 hours, wash with ethanol, and dry under reduced pressure at 40°C for 1 hour to obtain the clathrate;
[0029] 2) Preparation of garlic oil orally disintegrating tablets: Weigh garlic oil β-cyclodextrin inclusion compound and other components according to the formula ratio, mix thoroughly, pass through a 100-mesh sieve, and add an appropriate amount of 60% ethanol to prepare a soft material , pass through a 20-mesh sieve to granulate, dry at 40-50°C, and sieve the granules and fine powder between 20-mesh to 80-mesh, mix them evenly, and put them into a tablet ...
Embodiment 3
[0031] The formula of the oral fast-disintegrating tablet of garlic oil is as follows:
[0032]
[0033] To prepare, follow these steps:
[0034] 1) Preparation of β-cyclodextrin inclusion compound of garlic oil: According to the formula ratio, add 5 times the amount of water to the β-cyclodextrin and grind it thoroughly, then add garlic oil and mix well in a colloid mill, Grind into a paste, refrigerate at 4°C for 24 hours, wash with ethanol, and dry under reduced pressure at 40°C for 1 hour to obtain the clathrate;
[0035] 2) Preparation of garlic oil orally disintegrating tablets: fully mix garlic oil β-cyclodextrin inclusion complex and other components except magnesium stearate and 1 / 2 sodium carboxymethyl starch, and pass through 100 Mesh sieve, add appropriate amount of distilled water to prepare soft material, pass through 20 mesh sieve to granulate, dry at 40-50°C, and sieve the granules and fine powder between 20 mesh and 80 mesh, add the reserved sodium carboxy...
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