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Orally rapidly disintegrating tablet of garlic oil and preparation method thereof

A technology for oral fast disintegrating tablets and garlic oil, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc. and tissue damage, to achieve the effects of low cost, increased stability, and increased adaptability

Active Publication Date: 2018-04-10
HEILONGJIANG BAYI AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

3. It is safe to take. Ordinary tablets disintegrate slowly, and in the process of oral administration, it is easy to cause the risk of esophageal obstruction and tissue damage, while irritating drugs such as aspirin, potassium chloride, garlic oil, etc., due to their ingestion in the stomach Excessive local concentration can easily induce gastric and gastrointestinal bleeding

Method used

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  • Orally rapidly disintegrating tablet of garlic oil and preparation method thereof
  • Orally rapidly disintegrating tablet of garlic oil and preparation method thereof
  • Orally rapidly disintegrating tablet of garlic oil and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The formula of the oral fast-disintegrating tablet of garlic oil is as follows:

[0020]

[0021] To prepare, follow these steps:

[0022] 1) Preparation of β-cyclodextrin inclusion compound of garlic oil: According to the formula ratio, add 5 times the amount of water to the β-cyclodextrin and grind it thoroughly, then add garlic oil and mix well in a colloid mill, Grind into a paste, refrigerate at 4°C for 24 hours, wash with ethanol, and dry under reduced pressure at 40°C for 1 hour to obtain the clathrate;

[0023] 2) Preparation of garlic oil orally disintegrating tablets: Weigh the β-cyclodextrin inclusion compound of garlic oil and other components according to the formula ratio, mix thoroughly, pass through a 100-mesh sieve, put the mixed powder into a tablet machine and directly Tablet.

Embodiment 2

[0025] The formula of the oral fast-disintegrating tablet of garlic oil is as follows:

[0026]

[0027] To prepare, follow these steps:

[0028] 1) Preparation of β-cyclodextrin inclusion compound of garlic oil: According to the formula ratio, add 5 times the amount of water to the β-cyclodextrin and grind it thoroughly, then add garlic oil and mix well in a colloid mill, Grind into a paste, refrigerate at 4°C for 24 hours, wash with ethanol, and dry under reduced pressure at 40°C for 1 hour to obtain the clathrate;

[0029] 2) Preparation of garlic oil orally disintegrating tablets: Weigh garlic oil β-cyclodextrin inclusion compound and other components according to the formula ratio, mix thoroughly, pass through a 100-mesh sieve, and add an appropriate amount of 60% ethanol to prepare a soft material , pass through a 20-mesh sieve to granulate, dry at 40-50°C, and sieve the granules and fine powder between 20-mesh to 80-mesh, mix them evenly, and put them into a tablet ...

Embodiment 3

[0031] The formula of the oral fast-disintegrating tablet of garlic oil is as follows:

[0032]

[0033] To prepare, follow these steps:

[0034] 1) Preparation of β-cyclodextrin inclusion compound of garlic oil: According to the formula ratio, add 5 times the amount of water to the β-cyclodextrin and grind it thoroughly, then add garlic oil and mix well in a colloid mill, Grind into a paste, refrigerate at 4°C for 24 hours, wash with ethanol, and dry under reduced pressure at 40°C for 1 hour to obtain the clathrate;

[0035] 2) Preparation of garlic oil orally disintegrating tablets: fully mix garlic oil β-cyclodextrin inclusion complex and other components except magnesium stearate and 1 / 2 sodium carboxymethyl starch, and pass through 100 Mesh sieve, add appropriate amount of distilled water to prepare soft material, pass through 20 mesh sieve to granulate, dry at 40-50°C, and sieve the granules and fine powder between 20 mesh and 80 mesh, add the reserved sodium carboxy...

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Abstract

The invention discloses an orally rapidly disintegrating tablet of garlic oil and a preparation method thereof. Materials, using β-cyclodextrin inclusion technology and powder direct compression method or wet granulation compression method, using a tablet machine to compress into orally rapidly disintegrating tablets. Compared with the prior art, the present invention puts the medicine into the oral cavity, disintegrates within 25 seconds without drinking water, and has no foreign body and gritty feeling at the entrance, and the medicine enters the stomach by natural swallowing, and is in a highly dispersed state. The bad smell and irritation of the garlic oil are completely covered up, which can not only ensure the chemical stability of the garlic oil, but also exert a specific curative effect, and will not cause excessive irritation to the gastrointestinal tract. At the same time, the orally rapidly disintegrating tablet can be mass-produced using common tableting equipment.

Description

technical field [0001] The invention relates to the technical field of oral solid preparations, in particular to an orally rapidly disintegrating tablet of garlic oil and a preparation method thereof. Background technique [0002] The active ingredient garlic oil is a thioether compound produced by the cracking of alliin under the catalysis of allinase after the garlic cells are broken. Anti-cancer and anti-aging effects. The curative effect of garlic oil is obvious, but its special physical and chemical properties make its formulation design face great limitations. Garlic oil has a bad smell, is highly irritating to the gastrointestinal tract, and is volatile and unstable when exposed to light and heat. The commonly used dosage form on the market of present garlic oil is garlic oil soft capsule. Although garlic oil soft capsules have solved the problems of garlic oil, such as exposure to light, heat instability, easy oxidation and bad smell, it has not solved the problem...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/26A61K47/36A61K47/69A61K47/38A61K36/8962A61K9/20
Inventor 赵蕊蔡亚平赵辉邵星月贾桂燕
Owner HEILONGJIANG BAYI AGRICULTURAL UNIVERSITY
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