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Novel application of pineapple leaf extract

A technology of extract and pineapple leaf, which is applied in the direction of medical preparations containing active ingredients, drug combinations, plant raw materials, etc., can solve the problems of unreported pineapple leaves and rare pineapple leaves

Inactive Publication Date: 2015-03-25
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The records of pineapple leaves as medicine are relatively rare, especially the application of pineapple leaves or pineapple leaf extracts in the preparation of medicines for diseases such as small intestinal peristalsis and abnormal defecation due to weak contraction of intestinal smooth muscle

Method used

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  • Novel application of pineapple leaf extract

Examples

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Effect test

preparation example Construction

[0013] The preparation process of the pineapple leaf extract provided by the present invention is as follows: first, heat and extract the pineapple leaf at 30°C to 100°C for 3 times with 5-15 times the weight of the material in water or alcohols of various concentrations, each time for 1 to 3 hours ; or soak at room temperature for 2 to 10 days to obtain an extract. The alcohol solvent used can be methanol, ethanol, isopropanol, butanol, etc. or a water-containing alcohol solvent. Then the extract is concentrated under reduced pressure (pressure 90-98Kpa) at a temperature of 30-100°C, then dissolved in water 1-10 times the weight of the material, centrifuged or statically filtered, the precipitate is discarded, and the supernatant is taken; The supernatant is passed through an exchange column (macroporous adsorption resin, ion exchange resin, polyamide, etc.), firstly eluted with water, and the eluent is discarded; then eluted with a concentration greater than 70%, and the elu...

Embodiment 1

[0018] Take 1 kg of pineapple leaves, heat and extract 3 times with 5 times the amount of water at 100°C, each time for 3 hours, the extract is decompressed (pressure 98Kpa) and concentrated at 100°C, dissolved in water 1 times the weight of the material, left still, and taken The supernatant was passed through a polyamide column. First elute with water, discard the eluate, then elute with 70% ethanol, concentrate the eluate under reduced pressure (pressure 98Kpa) at 30°C, and freeze-dry to obtain the extract. The total phenolic components of the pineapple leaf extract were determined by colorimetry, and the content of the total phenolic components in the extract was about 30%.

Embodiment 2

[0020] Get 1 kg of pineapple leaves and heat and extract 15 times the amount of 70% ethanol at 60°C for 3 times, each time for 2 hours. , take the supernatant, and adsorb the resin through the macropores. First elute with water, discard the eluate, then elute with 95% ethanol, concentrate the eluate under reduced pressure (98Kpa) at 90°C, and dry under reduced pressure (98Kpa) to obtain the extract. The total phenolic components of the pineapple leaf extract were determined by colorimetry, and the content of the total phenolic components in the extract was about 80%.

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Abstract

The invention relates to novel application of pineapple leaf extract in the field of pharmacy, and particularly relates to second novel application of the pineapple leaf extract in the aspect of medicines. The pineapple leaf extract containing 30-80 percent of total phenol component is obtained by means of separation extraction. Experiment researches indicate that the pineapple leaf extract has an effect of promoting peristalsis of small intestine smooth muscles, and has a good relieving effect on diseases caused by decrease of intestine contraction. Specifically, the extract can be applied to preparation of medicine for treating degrease of intestinal smooth muscle contraction, slow intestinal peristalsis, enteroparesis and diseases caused by these symptoms.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract containing multiple active ingredients prepared from pineapple leaves, a preparation method and its new application in medicine, belonging to the technical field of traditional Chinese medicine. Background technique [0002] Pineapple is the fruit of Ananas comosus (L.) Merr.[Bromelia comosa L.; A.sativus Schult.Et Schult.f.], a bromeliad plant. It is native to the Americas and is now widely planted in tropical regions. It is planted in Fujian, Guangdong, Hainan, Guangxi, Yunnan and other places in my country. This product was first recorded in Qing Wu Qirui's "Plant Names and Facts", named after Ludouzi. The book records: "Pandouzi is produced in Guangdong. It is named Polo. It grows in the mountains and is like a radish. There are clusters of leaves on it, with long sharp teeth and deep teeth. It has a good taste, color and fragrance. The fruit is golden yellow when ripe, and the skin i...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61P1/10A61K127/00
CPCA61K36/88A61K2236/33A61K2236/51
Inventor 余煊邢东明雷帆王欣佩杜力军袁梽漪卢希姜敬非严孝金庞雨浓
Owner TSINGHUA UNIV
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