Preparation of effective parts of Lingxiaohua and its antidepressant application

An effective part, Ling Xiaohua technology, applied in the field of medicine

Active Publication Date: 2018-11-02
XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no relevant report on the preparation of effective parts of Lingxiaohua to treat depression.

Method used

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  • Preparation of effective parts of Lingxiaohua and its antidepressant application
  • Preparation of effective parts of Lingxiaohua and its antidepressant application
  • Preparation of effective parts of Lingxiaohua and its antidepressant application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0009] The effective part of Lingxiaohua of the present invention is to take 3.0Kg of Lingxiaohua dry flowers, add 10 times the weight and mass concentration of ethanol 30.0Kg (or 30.0L) with a mass concentration of 50% (or 60%, 80%, or 90%), soak for 30min, and ultrasonically Extract for 1 hour, filter to obtain a filtrate; add 8 times more ethanol (or 24.0 L) with a mass concentration of 50% (or 60%, 80%, or 90%) to the dregs, ultrasonically extract for 1 hour, and filter to obtain a filtrate; The two medicinal solutions were combined, concentrated under reduced pressure by a rotary evaporator until there was no alcohol smell, dissolved in pure water to form a suspension, and extracted with petroleum ether, ethyl acetate and n-butanol in sequence, wherein the ethyl acetate extract was concentrated under reduced pressure and Vacuum freeze-drying to obtain the effective part of Ling Xiaohua, which has passed the in vitro nerve cell protection evaluation experiment and various a...

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Abstract

The invention relates to an effective part of campsis grandiflora and an anti-depression application of the effective part of the campsis grandiflora, and aims at effectively solving the problem of clinical treatment of depressive disorder. According to the technical scheme, the preparation method comprises the following steps: adding 10fold ethyl alcohol with the mass concentration being 50%-90%, soaking campsis grandiflora for 30 minutes, carrying out ultrasonic extraction for an hour, and filtering to obtain a filtrate; adding 8fold ethyl alcohol with the mass concentration being 50%-90% to dregs, carrying out ultrasonic extraction for an hour, and filtering to obtain a filtrate; mixing the twice filtrates, carrying out vacuum concentration until no alcohol taste by virtue of a rotary evaporator; adding purified water, and dissolving into a suspension liquid; and sequentially extracting with petroleum ether, ethyl acetate and n-butyl alcohol, and carrying out vacuum concentration and vacuum freeze-drying on an ethyl acetate extract liquid, so as to obtain the effective part of the campsis grandiflora. The effective part of the campsis grandiflora disclosed by the invention is simple to prepare, low in cost, environment-friendly, and free of pollution, and is an innovation for medicines for treatment of the depressive disorder.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of an extract of Lingxiaohua in the preparation of antidepressant drugs. Background technique [0002] Lingxiaohua is the dried flower of Campsis grandiflora (Thunb.) K.sehum. and C.radicans (L) Seem. of the Bignoniaceae plant. It is a traditional Chinese medicine with the effect of promoting blood circulation and eliminating addiction in my country. It has the effects of cooling blood, removing blood stasis, and expelling wind. It is mainly used to treat irregular menstruation, amenorrhea, postpartum breast swelling, itchy skin, and acne. At present, it is known that Lingxiaohua has obvious effects in improving blood circulation, inhibiting thrombus, anti-oxidation, anti-inflammation, etc. It is mainly used in the treatment of cardiovascular and cerebrovascular diseases and gynecological diseases. The patent application No. 201010576491.6 discloses the application of an ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61P25/24A61K133/00
CPCA61K36/185A61K2236/333A61K2236/39A61K2236/51A61K2236/55
Inventor 于海川吴娇隋娟翟鹏飞张轶王侠段巨洪
Owner XINXIANG MEDICAL UNIV
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