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Preparation method and application of scoparia dulcis extract for resisting islet cell apoptosis

A technology of islet cells and Bingtangcao, applied in the field of medicine and biology, to improve cell apoptosis, significantly resist apoptosis of islet cells, and solve therapeutic problems

Active Publication Date: 2020-09-04
HAINAN MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition to controlling blood sugar, the use of drugs that can reduce β-cell apoptosis is the new core of modern T2DM treatment. There is no anti-diabetic drug used in clinical practice that directly targets β-cell apoptosis in islet cells.

Method used

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  • Preparation method and application of scoparia dulcis extract for resisting islet cell apoptosis
  • Preparation method and application of scoparia dulcis extract for resisting islet cell apoptosis
  • Preparation method and application of scoparia dulcis extract for resisting islet cell apoptosis

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Embodiment 1

[0028] Take 10kg of dried rock sugar grass, use ethanol or methanol to heat and reflux to extract, filter to obtain the extract, concentrate the extract under reduced pressure until it has no alcohol smell, and obtain the total extract; take the obtained total extract, add water to dissolve, add petroleum ether After extraction, the petroleum ether extract was discarded, and the remaining aqueous layer was extracted with dichloromethane, and the lower organic phase was recovered and concentrated under reduced pressure to obtain the total extract (180 g) extracted with dichloromethane.

[0029] Take the obtained total extract, use silica gel (200-300 mesh) column chromatography, and apply the sample by using the dry method loading, that is, first extract the total extract with dichloromethane and add a small amount of organic solvent to dissolve, then add a small amount of silica gel and mix well. After the organic solvent evaporates to dryness, grind it finely before loading th...

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Abstract

The invention belongs to the technical field of medical biology, and particularly relates to a preparation method and an application of a scoparia dulcis extract for resisting islet cell apoptosis. According to the preparation method, the scoparia dulcis extract is prepared through the steps of heating reflux, extraction, silica gel column chromatography and the like. Cell experiments and animal experiments prove that the scoparia dulcis extract prepared by the preparation method disclosed by the invention has a remarkable anti-islet cell apoptosis effect and has a bright application prospectin the aspect of preparing medicines for resisting islet cell apoptosis.

Description

technical field [0001] The invention belongs to the technical field of medicine and biology, and in particular relates to a preparation method and an application of an anti-apoptosis sugar grass extract. Background technique [0002] Diabetes is one of the chronic diseases that seriously threaten the health of all human beings, and its incidence is increasing year by year. Among diabetic patients, more than 90% are type 2 diabetes mellitus (T2DM). Insulin resistance is the main form of T2DM in the early stage. As the course of the disease prolongs, the function of pancreatic β-cells gradually decreases, and the disease gradually worsens. Apoptosis is the final form of decline in pancreatic β-cell function, which in turn leads to insufficient insulin secretion and elevated blood sugar. Although commercially available drugs can lower blood sugar in patients, apoptosis is still the main culprit in the gradual exacerbation of diabetes. In addition to good blood sugar control, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/80A61P3/10A61P5/50
CPCA61K36/80A61P3/10A61P5/50A61K2236/33A61K2236/55A61K2236/51
Inventor 张小坡孙万莹张勇张彩云邱军强李祎莹陈丽珍
Owner HAINAN MEDICAL COLLEGE
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