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A composition and technology of metronidazole, applied in the field of medicine, can solve problems such as easy damage to the acid-base environment of the vagina
Active Publication Date: 2015-04-29
BEIJING UNIS PHARMA
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(4) Excessive emphasis on hygiene: In order to maintain hygiene, some women often use medicinal lotion to lavage the vagina, which can easily destroy the acid-base environment of the vagina and cause bacterial vaginosis
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Embodiment 1
[0069] Metronidazole 375g, carbomer 934 450g, propylene glycol 1100g, solubilizer and pH regulator are sodium citrate and L-arginine 180g, sodium citrate 144g, L-arginine 36g.
[0070] Preparation method: take L-arginine, 50% by weight of sodium citrate, add 28 kg of water to dissolve completely, add carbomer 934, and stir evenly; add the remaining 50% by weight of sodium citrate, add 9.7 kg of water, and heat to 50°C; add metronidazole, stir evenly, add propylene glycol, stir evenly, fill, and obtain 10,000 gels.
Embodiment 2
[0072] Metronidazole 375g, carbomer 934 450g, propylene glycol 1100g, solubilizer and pH regulator are sodium citrate and L-arginine 180g, sodium citrate 140g, L-arginine 40g.
[0073] Preparation method: take L-arginine, 50% by weight of sodium citrate, add 28 kg of water to dissolve completely, add carbomer 934, and stir evenly; add the remaining 50% by weight of sodium citrate, add 9.7 kg of water, and heat to 50°C; add metronidazole, stir evenly, add propylene glycol, stir evenly, fill, and obtain 10,000 gels.
Embodiment 3
[0075] Metronidazole 375g, carbomer 934 450g, propylene glycol 1100g, solubilizer and pH regulator are sodium citrate and L-arginine 180g, sodium citrate 128.6g, L-arginine 51.4g.
[0076] Preparation method: take L-arginine, 50% by weight of sodium citrate, add 28 kg of water to dissolve completely, add carbomer 934, and stir evenly; add the remaining 50% by weight of sodium citrate, add 9.7 kg of water, and heat to 50°C; add metronidazole, stir evenly, add propylene glycol, stir evenly, fill, and obtain 10,000 gels.
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Abstract
The invention belongs to the technical field of medicines, and discloses a medicine composition containing metronidazole. The medicine composition comprises metronidazole, carbomer 934, propylene glycol, a solubilizer, a pH regulator and a complexing agent. The invention also discloses another medicine composition containing metronidazole. Another medicine composition disclosed by the invention is prepared from the following components in parts by weight: 35-45 parts of metronidazole, 40-50 parts of carbomer 934, 100-120 parts of propylene glycol, a solubilizer and 15-20 parts of a pH regulator, namely sodium citrate and L-arginine. Tests indicate that vaginal gel prepared from the medicine composition has better safety and stability.
Description
technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition containing metronidazole. Background technique [0002] Bacterial vaginosis (BV) is a mixed infection caused by Gardnerella vaginalis and some aerobic bacteria, which leads to an imbalance in the microecological balance in the vagina, resulting in increased vaginal discharge, fishy vaginal discharge, and itching and burning of the vulva. syndrome. It can be divided into haemophilus vaginitis, corynebacterium vaginitis, aerobic bacteria vaginitis, Gardnerella vaginitis and so on. The disease can also be transmitted through sexual contact, and the incidence rate is higher among people with disordered sexual relations. [0003] The causes of bacterial vaginosis mainly include the following aspects: (1) Indirect contact infection: contact with toilets, bathtubs, bath chairs, towels in public toilets contaminated by bacteria, and use of uncl...
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