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A kind of preparation method of calamine lotion

A kind of calamine lotion and technology of calamine, applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, medical formulas, etc., can solve the problem of not easy to agglomerate after long-term storage, difficult to obtain powder, Produce gritty feeling and other problems, achieve the effect of saving follow-up work, improving the stability of the suspension, and improving the solubility of the powder

Active Publication Date: 2019-03-01
HUNAN ER KANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the calamine lotion prepared by this method has a slow layered sedimentation speed and is not easy to agglomerate after long-term storage, it is difficult to obtain a fine powder with a nylon plastic mesh bag, which will produce a gritty feeling when applied, and after drying easy to fall off

Method used

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  • A kind of preparation method of calamine lotion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 150kg of calamine and 500kg of zinc oxide were prepared into superfine powders with a diameter of 3 μm through a jet mill, and the two were mixed through dry grinding, and washed repeatedly with 10L of isopropanol and 30L of glycerol, and then Add colloidal microcrystalline cellulose, a mixture of potassium citrate and sodium tartrate (mass ratio 1:1), glycerin, magnesium stearate = 1:0.2:0.9:0.01 mixed suspension stabilizer, and prepare a concentration of 30%- 50% suspension, and finally filled to get the finished product.

Embodiment 2

[0030] 150kg of calamine and 500kg of zinc oxide were prepared into superfine powders with a diameter of 5 μm through a jet mill, and the two were mixed through dry grinding, and washed repeatedly with 10L of isopropanol and 50L of glycerol, and then washed repeatedly. Add colloidal microcrystalline cellulose, potassium dihydrogen phosphate, glycerin, magnesium stearate = 1:0.3:1.0:0.03 to mix suspension stabilizers, prepare a suspension with a concentration of 30%-50%, and finally fill to obtain a finished product.

Embodiment 3

[0032] 150kg of calamine and 500kg of zinc oxide were prepared into superfine powders with a diameter of 8 μm through a jet mill, and the two were mixed through dry grinding, and washed repeatedly with 10L of isopropanol and 80L of glycerol, and then Add colloidal microcrystalline cellulose, sodium tartrate, glycerin, magnesium stearate = 1:0.3:1.0:0.05 to mix suspension stabilizers, prepare a suspension with a concentration of 30%-50%, and finally fill to obtain a finished product.

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Abstract

The invention provides a preparation method of a calamine lotion. The method specifically includes the steps of: mixing and grinding, cleaning, liquid preparation mixing, and filling, thus obtaining a finished product. The product obtained by the method provided by the invention has suspension liquid with good stability and lasting suspension property, the microorganisms are effectively controlled, and no gravel feel is generated during application of the lotion.

Description

technical field [0001] The invention relates to a preparation method of calamine lotion, in particular to a method of using superfine powder of calamine and zinc oxide through dry grinding, mixing liquid and stirring to make calamine suspension, which belongs to pharmaceutical manufacturing field. Background technique [0002] The main components of calamine lotion are calamine and zinc oxide, which is a pink suspension with a long clinical application time for skin external application. It has the effect of astringent and protecting the skin, and is suitable for acute itching skin diseases such as urticaria and prickly heat. [0003] The preparation of calamine is mainly external lotion, which is to grind calamine and zinc oxide into fine powder, add appropriate amount of water and glycerin to make a solid suspension, shake well before each use, and apply an appropriate amount on the affected area . The traditional preparation method of calamine lotion is to grind 150g o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/10A61K33/30A61K47/38A61K47/10A61K47/12A61P17/04
Inventor 帅放文王向峰章家伟
Owner HUNAN ER KANG PHARMA
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