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A Method for Ex vivo Measurement and Calculation of Eye Shape, Eye Axis and Curvature of Experimental Animals

A technology for experimental animals and in vitro eyeballs, applied in measurement devices, instruments, optical devices, etc., can solve problems such as unreported reports, increase accuracy and reliability, increase precision, and ensure objectivity and accuracy. Effect

Active Publication Date: 2018-06-29
JINSHAN HOSPITAL FUDAN UNIV
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Problems solved by technology

[0005] To sum up, the method of measuring the eye position and eyeball shape of experimental animals needs to be improved urgently, but there is no report on the method of measuring the eye position and eyeball shape of experimental animals with fixed measurement position and digital simulation

Method used

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  • A Method for Ex vivo Measurement and Calculation of Eye Shape, Eye Axis and Curvature of Experimental Animals
  • A Method for Ex vivo Measurement and Calculation of Eye Shape, Eye Axis and Curvature of Experimental Animals
  • A Method for Ex vivo Measurement and Calculation of Eye Shape, Eye Axis and Curvature of Experimental Animals

Examples

Experimental program
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Embodiment

[0040] Example: Studying the morphological changes of guinea pig eyeballs by fitting curves.

[0041] attached Figure 4 Shown in 8 weeks old and 3 weeks old guinea pig isolated eye morphology comparison. Figure A is the result of circle fitting on the side of the cornea of ​​the 8-week-old guinea pig, and its radius of curvature can be observed. Figure B is the fitting curve equation after the fitting of Figure A, rotated by the difference angle and moved to the same position as that of the 3-week-old guinea pig The curve fitting curve on the side of the eyeball cornea has the same circle center, and the change of the corneal curvature radius of the 8-week-old guinea pig and the 3-week-old guinea pig can be clearly compared from the picture B: the curvature radius of the cornea of ​​the 8-week-old guinea pig is larger than that of the 3-week-old guinea pig . Figure C is the fitting result of the scleral conic curve at the posterior pole of the eyeball of the 8-week-old guin...

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Abstract

The invention relates to a method for measuring and calculating the eyeball shape, eye axis and curvature of experimental animals in vitro. Optical instruments are used to photograph the eyeballs in a fixed position, and the eyeball shape, eye axis and curvature of the experimental animals are calculated by a digital simulation method. Its advantages are as follows: the method of the present invention adopts optical measurement, and after the non-contact measurement of the eyeball outline through the macro camera, the corresponding pixel conversion is carried out for measurement, which greatly increases the accuracy of the result and makes some tiny eyeball structure changes It can be found and observed; the method of the present invention simulates an oblique ellipse with clear mathematical equations by simulating the eyeballs of guinea pigs, and calculates the corresponding angles through the principles of analytic geometry and trigonometric functions in mathematics, which greatly increases the accuracy of the results. At the same time, the above results are obtained by calculation, which greatly guarantees the objectivity of the results and provides a basis for the analysis of the eyeball structure of guinea pigs in different experimental groups.

Description

【Technical field】 [0001] The invention relates to the technical field of biological parameter measurement for basic ophthalmology research, in particular to a method for measuring and calculating the eyeball shape, eye axis and curvature of experimental animals in vitro. 【Background technique】 [0002] Modern life science research requires that the results of animal experiments be accurate, reliable, repeatable and comparable, that is, different people can get exactly the same experimental results when doing the same animal experiments at different times and in different spaces. This requires us to choose standardized experimental animals and conduct experiments under standard conditions. Guinea pigs, as a good experimental animal, have been studied more and more in experimental myopia models and retinal physiology. Therefore, the measurement of guinea pig eye position and eyeball shape has gradually become an important part of experimental myopia models and retinal physiolo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01B11/24G01B11/255G01B11/02
Inventor 邸悦陆娜周晓东乔彤周行涛陈志李炳刘睿罗秀梅
Owner JINSHAN HOSPITAL FUDAN UNIV
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