Blood flow restriction apparatus and method for embolus removal in human vasculature

Abstract

A mechanical thrombectomy device system is disclosed that is made from a single piece of biocompatible material, including a proximal flow block portion / feature, and / or, a flow block feature in the device body portion, a guidewire like delivery portion and an expandable, treatment portion. The construction of the device from a single piece allows for a seamless transition from the delivery portion to the treatment portion, thus removing any joints or bonding of the two portions together as separate pieces. This improves the strength of the system as a whole and greatly reduces the possibility of the two parts unintentionally detaching from each other. Likewise, the distal treatment portion is cut from a piece of material the same size as the proximal delivery portion, allowing the device to be compacted to a similar size profile giving it delivery advantages including a lower delivery force required and requiring small access systems, and the treatment portion's surface can be altered to enhance embolus affinity by either coating with a substance or changing the texture by mechanical or chemical means.

Description

[0001] Cross References to Related Applications [0002] This application claims all the benefits of the Paris Convention and the priority of US Patent Application No. 61 / 768,336, filed February 22, 2013. The contents of the aforementioned patent applications are incorporated herein by reference as if fully set forth herein in their entirety. technical field [0003] The present invention generally relates to devices and methods useful for thrombus recovery and resection devices for the treatment of, inter alia, ischemic stroke. In particular, it relates to medical devices which may be used as mechanical thrombectomy devices to restore or address obstructions caused by narrowed or obstructed blood vessels in the neurovascular system and / or the cardiovascular system, to restore the flow of oxygenated blood after removal of the obstruction or Oxygen-rich blood flow is restored distal to the obstruction. Background technique [0004] The present invention relates to medical ...

AI Technical Summary

Problems solved by technology

The main disadvantages of the above-mentioned existing mechanical thrombectomy devices are: 1) For devices like filters, the filters are often bulky and difficult to transport and deploy, requiring larger guide catheters to completely eliminate thrombus

Furthermore, it is difficult to precisely and predictably adjust for the desired motion pattern to properly position the device within the vessel

The device may drift, twist, or not conform sufficiently to the shape of the vessel wall within the vessel to effectively remove the clot

2) For devices in the shape of a corkscrew guide wire, such devices can only capture and eliminate hard thrombi, or thrombus that can be affected by certain mechanical changes, such as thrombus that itself is restricted in one place to form a single block

[0009] During thrombectomy, the blood vessel does not immediately re-conduct, and if there is still a small thrombus detached from a large thrombus, the device cannot capture this small thrombus; 3) If there is a small thrombus detached from a large thrombus, Existing mechanical thrombectomy devices similar to stents cannot capture this small thrombus, which may lead to many complications, such as distal small vessel occlusion, vessel dissection, perforation and cerebral hemorrhage caused by vessel overtreatment

[0010] Common shortcomings of existing devices include: 1) The device can capture the thrombus, but then lose control of the thrombus and incidentally migrate / deposit the thrombus to another area of ​​the neurovasculature, causing another area of ​​the neurovasculature potential for new strokes; 2) the device cannot capture a small thrombus detached from a large thrombus and prevent the small thrombus from migrating to more distant regions within the neurovascular system; 3) the relatively large size of the device limits the Device for treatment of distal small diameter vessels

[0011] Another drawback of existing mechanical thrombectomy devices is that these devices are made from two or more distinct parts, thus requiring additional coupling structures or bonding between the delivery system and the treatment device

None of the existing mechanical medical thrombectomy devices can meet all the necessary needs

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