Microparticle release chip of zinc oxide nanorod array, preparation method and release method

A zinc oxide nanorod, array technology, applied in biochemical equipment and methods, cell dissociation methods, microorganisms, etc., can solve the problems of complex biochemical reactions, poor stability, large consumption of precious biochemical reagents, etc., and achieve low damage , good active effect

Active Publication Date: 2017-10-17
WUHAN YZY MEDICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The disadvantages of traditional substrate-free chips are: (1) poor stability, weak ability to capture macromolecules and cells, and cannot meet some long-term detection requirements; (2) some complex biochemical reactions occur, and the consumption of expensive biochemical reagents Big

Method used

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  • Microparticle release chip of zinc oxide nanorod array, preparation method and release method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A microparticle release chip of a zinc oxide nanorod array substrate, comprising a base and a cover provided on the base, the bottom of the cover is provided with a cover channel, and the top of the base is provided with a channel corresponding to the position of the cover channel. The negative film channel, the cover film channel and the negative film channel form a capture cavity, and the two ends of the cover plate are respectively provided with an input port and an output port communicating with the capture cavity. Zinc oxide nanorod arrays are arranged in both the cover sheet channel and the bottom sheet channel. The depth of the cover channel decreases sequentially from the input port to the output port. The depth of the film channel is a constant value.

[0032] Specifically, the cover channel and the negative channel are both isosceles trapezoidal channels and the positions of the cover channel and the negative channel are correspondingly up and down, and the u...

Embodiment 2

[0050] A microparticle release chip of a zinc oxide nanorod array substrate, comprising a base and a cover provided on the base, the bottom of the cover is provided with a cover channel, and the top of the base is provided with a channel corresponding to the position of the cover channel. The negative film channel, the cover film channel and the negative film channel form a capture cavity, and the two ends of the cover plate are respectively provided with an input port and an output port communicating with the capture cavity. Zinc oxide nanorod arrays are arranged in both the cover sheet channel and the bottom sheet channel. The depth of the cover channel decreases sequentially from the input port to the output port. The depth of the film channel decreases successively from the input port to the output port.

[0051] Specifically, the cover channel and the negative channel are both isosceles trapezoidal channels and the positions of the cover channel and the negative channel ...

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Abstract

The invention discloses a particle release chip for a zinc oxide nanorod array substrate. The chip comprises a base plate and a cover plate arranged on the base plate in a covering manner, wherein the cover plate bottom surface and the base plate top surface are both provided with channels so as to form a capturing cavity; the capturing cavity is internally provided with a zinc oxide nanorod array. The cover plate is provided with an input port and an output port; the depth of the channel of the cover plate is gradually decreased from the input port to the direction of the output port, and the depth of the channel of the base plate is gradually decreased from the input port to the direction of the output port or the depth of the channel of the base plate is a constant value. The invention also discloses a preparation method of the particle release chip for the zinc oxide nanorod array substrate and a cell release method of the chip taking the zinc oxidenanorod array as the substrate. The zinc oxide nanorod array is of a flexible substrate, which serves as a platform for sliding particles; the chip can be used for screening circulating tumor cells of which the sizes meet requirements; the particles released from the chip are better in activity and low in harm.

Description

technical field [0001] The invention belongs to the field of chemical analysis and biotechnology, and in particular relates to a particle release chip with a zinc oxide nanorod array substrate, a preparation method for a particle release chip with a zinc oxide nanorod array substrate, and a zinc oxide nanorod array substrate. The method of releasing cells from the bottom chip is suitable for tumor diagnosis, adjuvant therapy and biochemical analysis research. Background technique [0002] Highly oriented ZnO nanorod arrays on solid substrates have attracted great attention in blood detection due to their outstanding performance. The template method was used to synthesize ZnO nanorod arrays. However, the template preparation process is complicated, and the prepared nanorod arrays are easily polluted when the template is removed. Nano-structure. At present, a cheap, simple and effective method has been found to prepare ZnO nanorod arrays. The water-bath method has simple op...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12M3/00C12N5/09
CPCC12M45/00C12N5/0693C12N2509/00
Inventor 李颂战高易凡刘侃张南刚刘松林
Owner WUHAN YZY MEDICAL SCI & TECH
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