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Systems and methods for determining hepatic function from liver scans

A liver and scanner technology, applied in computer tomography scanners, image data processing, character and pattern recognition, etc., can solve invasive problems

Active Publication Date: 2016-03-23
肝病定量分析公司
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Problems solved by technology

However, biopsies are invasive because they require removal of part of the liver for analysis

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  • Systems and methods for determining hepatic function from liver scans
  • Systems and methods for determining hepatic function from liver scans
  • Systems and methods for determining hepatic function from liver scans

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[0096] Example: If the liver volume calculated in the above example is 952, the IBW for a 62-inch female would be = 110 pounds, and

[0097] Normalized liver volume (corrected for body size) = 8.7cc / lbIBW

[0098] Estimated laparoscopy score (estPS)

[0099] Laparoscopy may provide an indication of the "smoothness" or "graininess" or "nodularity" of the liver. QLSSD can calculate an estimated laparoscopic score (estPS) by combining several parameters. In one embodiment, estPS is calculated as follows:

[0100] estPS1=4.342-2.008RR-0.0206PHM+18.15 / RL

[0101] where RL is the right lobe length in centimeters and RR is the redistribution ratio, which is calculated as follows:

[0102] (RR)=[(Lp / Sp / 2.5)+(Lp / BMp / 17.5)] / 2

[0103] Here, Lp, Sp, and BMp are pixel counts from posterior planar views of the liver, spleen, and bone marrow, respectively.

[0104] Laparoscopic evaluation of the liver can be correlated with tissue fibrosis measurements. Thus, estPS derived from QLS...

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Abstract

Systems and methods described herein determine an objective metric for analyzing health of a patient's liver. In some embodiments, the system may include a scanner that can detect radiation counts responsive to administration of radioactive compound to a patient. Further, the system may include an image detection module that can access image data responsive to the detected radiation counts by the scanner. The image detection module can programmatically identify a first region of interest corresponding to a liver of the patient from the image data. A parameter calculator module can programmatically determine a first attribute associated with the first region of interest and calculate a first parameter indicating health of the liver of the patient based at least in part on the first attribute associated with the first region of interest.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Patent Application No. 61 / 847,313, filed July 17, 2013, the disclosure of which is incorporated herein by reference in its entirety. Background technique [0003] Chronic liver disease is characterized by the progressive formation of scar tissue (fibrosis) in response to many forms of chronic liver inflammation. This can lead to cirrhosis, which reduces liver function. A liver biopsy is one of the most common methods of testing liver health. However, biopsies are invasive because they require removal of part of the liver for analysis. Furthermore, liver biopsy analysis is assessed subjectively and can also vary depending on the location of the biopsy. Contents of the invention [0004] The systems and methods described herein may be implemented by a computer system including computer hardware. A computer system may include one or more physical computing devices,...

Claims

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Application Information

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IPC IPC(8): A61B6/03A61B6/00G06T7/60G16Z99/00
CPCA61B6/037A61B6/469A61B6/50A61B6/5217G06T2207/10108G06T2207/30056G06T7/0014G06T7/50G06T7/13G16H50/30G16Z99/00A61B6/032A61B6/481A61B6/5205G06T7/0012G06T2207/30008
Inventor 迪庞卡·古什约翰·卡尔·赫夫斯
Owner 肝病定量分析公司
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