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Application of Lvji cough asthma tablets to preparation of medicine for inhibiting cell proliferation of prostate cancer cells PC-3

A technology of PC-3 and cell proliferation, which is applied in drug combination, antineoplastic drugs, pharmaceutical formulations, etc., and can solve problems such as backwardness, many impurities, and impact on clinical application

Inactive Publication Date: 2016-05-04
济南新时代医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the application of Lvjikechuan Tablets in the preparation of drugs for inhibiting the proliferation of human prostate cancer cell PC-3 cells, and there is no report on the use of supercritical extraction in the extraction and preparation of Lvjikechuan Tablets , while the traditional water decoction and ethanol reflux extraction method, the process is rough, backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the clinical application of this product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take 200g of Chrysanthemum splendens, 200g of Chicken Yateng, 100g of Gonggongmu, 100g of Tongguanteng, 100g of Baiji, 100g of Polygonum cuspidatum, 100g of Speranthema spp., and 100g of Polygonatum, and add them to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 5%, the extraction pressure is 25MPa, the temperature is 40°C, and the CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 750min, and the supercritical extract is obtained. The supercritical extract is added to starch and 70% ethanol to make granules, dried, and pressed into tablets to make 200 tablets, each weighing 0.50g.

[0025] After testing, the content of emodin in the finished product is 3.28mg / tablet.

Embodiment 2

[0027] Take 200g of Chrysanthemum splendens, 200g of Chicken Yateng, 100g of Gonggongmu, 100g of Tongguanteng, 100g of Baiji, 100g of Polygonum cuspidatum, 100g of Speranthema spp., and 100g of Polygonatum, and add them to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 4% by volume of the total extraction solvent. The extraction pressure is 15MPa, the temperature is 30°C, and the CO 2 The flow rate is 1ml / g crude drug·min, the extraction time is 900min, and the supercritical extract is obtained. The supercritical extract is added to starch and 70% ethanol to make granules, dried, and pressed into tablets to make 200 tablets, each weighing 0.50g.

[0028] After testing, the content of emodin in the finished product is 1.65mg / tablet.

Embodiment 3

[0030] Take 200g of Chrysanthemum splendens, 200g of Chicken Yateng, 100g of Gonggongmu, 100g of Tongguanteng, 100g of Baiji, 100g of Polygonum cuspidatum, 100g of Speranthema spp., and 100g of Polygonatum, and add them to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 60°C, and the CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 800min, and the supercritical extract is obtained. The supercritical extract is added to starch and 70% ethanol to make granules, dried, and pressed into tablets to make 200 tablets, each weighing 0.50g.

[0031] After testing, the content of emodin in the finished product is 2.08mg / tablet.

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PUM

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Abstract

The invention belongs to the technical field of traditional Chinese medicine and particularly relates to application of cough asthma tablets to preparation of medicine for inhibiting cell proliferation of prostate cancer cells PC-3 and a preparing method for the cough asthma tablets. The cough asthma tablets are prepared from 200 g of ll-grass of creeping bulbophyllum, 200 g of paederia scandens, 100 g of mahonia fortuneiFedde, 100 g of marsdenia tenacissima, 100 g of rhizoma bletillae, 100 g of polygonum cuspidatum, 100 g of speranskia tuberculata andd 100 g of rhizoma polygonati by the adoption of supercritical extraction. The rheum emodin content is increased greatly.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to the application of Lvjikechuan Tablets in the preparation of drugs for inhibiting the proliferation of prostate cancer cell PC-3 cells and the preparation method of Lvjikechuan Tablets. Background technique [0002] The standard number of Lvji Kechuan Granules is WS-10616 (ZD-0616)-2002, which is recorded in the National Compilation of Chinese Patent Medicine Standards Internal Medicine Pulmonary System (II) Volume. Made from 200g of Chlorina striata 200g, 200g of Jiyateng, 100g of Gongluomu, 100g of Tongguanteng, 100g of Baiji, 100g of Polygonum cuspidatum, 100g of Speranthema japonicus, and 100g of Huangjing. It is used for cough, hot flashes and night sweats caused by heat-dryness invading the lungs. [0003] In the prior art, there is no report on the application of Lvjikechuan Tablets in the preparation of drugs for inhibiting the prolifera...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61K9/20A61P35/00
CPCA61K36/898A61K9/2059A61K36/185A61K36/27A61K36/29A61K36/47A61K36/704A61K36/74A61K36/8969A61K2236/37A61K2236/51A61K2300/00
Inventor 王静
Owner 济南新时代医药科技有限公司
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