Calibration standard solution configuration device and calibration method for tissue oxygen detector

A technology for calibrating standards and configuring devices, applied in measurement devices, instruments, scientific instruments, etc., can solve the problems of high requirements of blood gas analyzers and complicated configuration process, and achieve the effects of simple calibration process, wide simulation range and high accuracy

Active Publication Date: 2018-05-29
ZHEJIANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The present invention mainly solves the technical problems in the prior art that the configuration process is relatively cumbersome and has high requirements for the blood gas analyzer, and provides a liquid model that can automatically configure different oxygen saturations, high precision and fast tissue oxygen detection instrument calibration standard liquid configuration device, and at the same time provide a tissue oxygen detector calibration method that can complete the calibration without the help of a blood gas analyzer and has high accuracy of test results

Method used

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  • Calibration standard solution configuration device and calibration method for tissue oxygen detector
  • Calibration standard solution configuration device and calibration method for tissue oxygen detector
  • Calibration standard solution configuration device and calibration method for tissue oxygen detector

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Experimental program
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Embodiment

[0031] Embodiment: A tissue oxygen detector calibration standard solution configuration device of this embodiment, such as figure 1As shown, it includes whole blood feed container 1, fat emulsion feed container 2, buffer solution feed container 3, feed quantitative pump 4, feed solenoid valve 5, raw material U-shaped mixing channel 6, oxygenation container 7, deoxygenation Container 8, intake valve 9, high-pressure oxygen cylinder 10, high-pressure nitrogen cylinder 11, discharge quantitative pump 12, discharge solenoid valve 13, discharge U-shaped mixing channel 14, controller 15, computer 16, discharge liquid container 17 and magnetic stirrer 18.

[0032] The 3 feeding containers are respectively connected to pipelines, and the 3 pipelines are merged into one pipeline through a feed quantitative pump and a feed solenoid valve, and then branched into two pipelines through a U-shaped mixing channel for raw materials. Connect the oxygenation and deoxygenation vessels separatel...

Embodiment approach

[0047] The specific implementation is as follows:

[0048] (1), select the raw material solution

[0049] The raw material solution for configuring the liquid tissue model is prepared by mixing whole blood of normal people, scattering medium and buffer solution. The whole blood of normal people is the absorption medium, and the fat emulsion is the scattering medium. The role of the buffer is to keep the pH of the tissue model within the range of normal human blood pH (7.35-7.45) and isotonic with blood cells. The formula of the buffer is as follows: 20gK is dissolved in every 1000ml buffer 2 HPO 4 ·3H 2 O and 2.9gNaH 2 PO 4 2H 2 O, the rest is deionized distilled water. According to the calculation, the pH value of the buffer solution is stable at 7.4 at room temperature; meanwhile, its osmolarity is 0.3 mol / L, which is isotonic with human blood.

[0050] Table 1 lists the formulations of several commonly used liquid tissue models, and the absorption coefficient μ of ...

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Abstract

The invention discloses a device for preparing tissue oximeter calibrating standard liquid and a calibration method. Normal human whole blood, fat emulsion and a phosphate buffer solution are taken as raw materials, and are automatically prepared into a liquid model according to different needs; a part of the liquid model is conveyed into a pure oxygen environment for oxygenation, the other part of the liquid model is conveyed into a pure nitrogen environment for deoxygenation, and after a period of time, a fully-oxygenated liquid model and a fully-deoxygenated liquid model are obtained; the fully-oxygenated liquid model and the fully-deoxygenated liquid model are automatically mixed proportionally into liquid models with different oxygen saturations of 0-100% as outputs, and a tissue oximeter to be calibrated is used for measuring blood oxygen saturations of the liquid models so as to obtain a tissue oximeter calibrating straight line. The device has the advantages of capability of simulating optical absorbing and scattering properties of a variety of tissues, high accuracy, awide simulating range, high degree of automation, and simpliness and high convenience in calibrating process. The scheme provided by the invention is applicable to calibration of the tissue oximeter.

Description

technical field [0001] The invention relates to the field of equipment calibration, in particular to a calibration standard solution configuration device and a calibration method for a tissue oxygen detector. Background technique [0002] Using near infrared spectroscopy (NIRS) to realize non-destructive, real-time, continuous and quantitative detection of the oxygenation state of human tissue is an important technology in the field of biomedical optics, and it is still a research hotspot in this field. [0003] The tissue oxygen detector is a device used to detect the oxygenation status of the tissue. In order to ensure the accuracy of the test results, the tissue oxygen detector needs to be calibrated regularly. [0004] The State Intellectual Property Office of the People's Republic of China published the patent document (publication number: CN1864629A) titled "Method of Calibrating Tissue Oxygen Detector with Blood Gas Analyzer" on November 22, 2006. Fat emulsion, K 2 ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N1/38G01N21/01G01N21/359G01N21/3577
Inventor 张武明王颖哲熊先胤邓鸿超
Owner ZHEJIANG UNIV
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