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Primary liver cancer with bile duct tumor thrombus biomarker and its use

A primary liver cancer, marker technology, applied in instruments, measuring devices, scientific instruments, etc., can solve problems such as confusion

Active Publication Date: 2018-11-02
上海百趣生物医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in addition to being confused with primary liver cancer with bile duct compression, the disease that is most likely to be misdiagnosed is malignant disease of the biliary tract. At the same time, it can also be confused with benign diseases of the biliary system, such as bile duct stones, bile duct cysts and other diseases

Method used

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  • Primary liver cancer with bile duct tumor thrombus biomarker and its use
  • Primary liver cancer with bile duct tumor thrombus biomarker and its use
  • Primary liver cancer with bile duct tumor thrombus biomarker and its use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0100] Example 1 Using 5,6-dihydrouracil as a single marker to diagnose BDTT

[0101] After the ROC curve (receiver operating characteristic curve) test, it can be seen that the AUC (area under the ROC curve) is 0.8536, the diagnostic sensitivity is 69.81%, and the specificity is 0%.

Embodiment 2

[0102] Example 2 Using D-aspartic acid as a single marker to diagnose BDTT

[0103] After the ROC curve (receiver operating characteristic curve) test, it can be seen that the AUC (area under the ROC curve) is 0.9669, the diagnostic sensitivity is 95.28%, and the specificity is 10.81%.

Embodiment 3

[0104] Example 3 Using threonic acid as a single marker to diagnose BDTT

[0105] After the ROC curve (receiver operating characteristic curve) test, it can be seen that the AUC (area under the ROC curve) is 0.4598, the diagnostic sensitivity is 39.62%, and the specificity is 29.73%.

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Abstract

The invention provides a marker used for distinguishing primary liver cancer accompanying bile duct cancer emboli from bile duct system diseases. The sensitivity and specificity obtained when five indexes, namely 5,6-dihydrouracil, D-aspartic acid, stearic acid, docosanoic acid and tetracosanoic acid, are combined are effective and reach 99.06% and 0 respectively compared with those obtained in single-index diagnosis.

Description

technical field [0001] The present invention relates to a primary liver cancer with bile duct tumor thrombus marker, in particular, further specifically relates to G01N33 / 68. Background technique [0002] Primary liver cancer with biliary tumor thrombus (BDTT) is characterized by the metastasis of hepatocellular carcinoma into the biliary system causing obstructive jaundice, and is the most common secondary tumor of the biliary system. However, in addition to being confused with primary liver cancer with bile duct compression, the disease that is most likely to be misdiagnosed is malignant disease of the biliary tract. At the same time, it can also be confused with benign diseases of the biliary system, such as bile duct stones, bile duct cysts and other diseases . According to statistics, the overall preoperative clinical misdiagnosis rate was 16.6% (65 / 392), and the late preoperative clinical misdiagnosis rate (9.8%, 26 / 264) was lower than the early stage (30.5%, 39 / 128)....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 邓军亮楼格尔吴洪强
Owner 上海百趣生物医学科技有限公司
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