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It should be recognized that the polymers and excipient components as described above may be present together with the active ingredients or active materials, for example in a blend, wherein the final composition is prepared under high shear of the blend, may is the pressure exerted on it, resulting in the encapsulation of the active ingredient, thereby significantly delaying or prolonging the release of the active ingredient, thus reducing the pungent and irritating properties of the active ingredient
Method used
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Embodiment 1
[0145] The pepper compositions of Examples 1, 2, 3 and 4 were subjected to accelerated stability studies at 40±2°C / 75±5% relative humidity (RH) according to ICH guidelines. The results of this study are as follows,
[0146]
[0147] in conclusion:
[0148] Stability data for 3 months at 40°C and 75% relative humidity were found to be satisfactory for assay and dissolution.
[0149] dissolve data
[0150]
[0151] in conclusion:
[0152] Dissolution studies did not show any release in 0.1 N hydrochloric acid within 2 hours, and capsaicin was completely released over a 6 hour time period in pH 7.4 phosphate buffer with sodium lauryl sulfate.
[0153] Advantages of the invention
[0154] 1. Provide free-flowing, non-sticky solid compositions of oily, pungent, pungent, odorous active substances, wherein the inherent nutritional and biological benefits of said active substances are maintained at high concentrations, But without the discomfort associated with the active s...
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PUM
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Abstract
A composition of oily, pungent and odoriferous substances and a process for preparation thereof are described, in particular an extended and sustained release of a stable, free flowing, solid composition of one or more of substances such as capsicum, black pepper, ginger, mustard, cinnamon, garlic, onion, paprika, turmeric and the like, extracts thereof, and / or components thereof, and a process for preparation thereof are described. For example, compositions comprise a substance such as capsicum containing capsaicinoid components, which include for example capsaicin, dihydro-capsaicin, and / or nor-dihydro-capsaicin. The composition can eliminate the discomfort by facilitating intestinal absorption of the active ingredient and thereby minimizing / eliminating the discomfort caused by the residual unabsorbed active ingredient, and can be particularly suitable for formulating into consumable dry syrups, tablets, capsules, liquid syrups, health drinks, diet drinks, fruit juices, and / or soft drinks, which can be useful in reduction of body weight.
Description
technical field [0001] In general, the present invention relates to oily, pungent, odorous substances and methods for their preparation. In particular, the present invention relates to the prolonged and sustained release of stable, free-flowing, solid compositions of compositions of one or more odorous substances such as chilli pepper, black pepper, ginger, mustard, cinnamon, garlic, onion, Paprika, turmeric, etc., extracts thereof, and / or components thereof. For example, the composition includes capsicum and the like, and the capsicum contains a capsaicin component, and the substance may include one or more of capsaicin, dihydrocapsaicin, and / or desdihydrocapsaicin, and the The preparation method of said composition. Background technique [0002] In modern times, obesity is considered a cause of serious complications in diseases such as diabetes and myocardial infarction. It is also a major factor in many diseases, including coronary heart disease (CHD), hypertension, no...
Claims
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Application Information
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