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Staining reagents and other liquids and related technologies for biological specimen tissue processing

A liquid, specimen technology, applied in the field of automatic tissue processing, which can solve the problems of not allowing control of staining characteristics, slowness, etc.

Active Publication Date: 2021-12-17
VENTANA MEDICAL SYST INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Utilizing the apparatus described in the '326 patent and similar machinery for this process would be unacceptably slow
Moreover, these mechanisms do not allow control of the staining properties

Method used

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  • Staining reagents and other liquids and related technologies for biological specimen tissue processing
  • Staining reagents and other liquids and related technologies for biological specimen tissue processing
  • Staining reagents and other liquids and related technologies for biological specimen tissue processing

Examples

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Embodiment Construction

[0119] It is often desirable to increase the consistency and controllability of certain attributes (eg, staining intensity) of tissue-processed specimens. Treatment time (ie, the duration of a given tissue treatment) and treatment temperature (ie, the temperature at which a given tissue treatment is performed) are two variables that affect most, if not all, of these attributes. Automated organizational systems configured in accordance with at least some embodiments of the present technology include features that facilitate consistency and / or controllability of processing times and / or processing temperatures. For example, at least some of these systems include a stainer having a processing head capable of precisely performing controlled liquid dispensing and removal operations. These dyers can also have an internal environment that can be maintained at an elevated baseline temperature. It is expected that the performance (eg, with respect to quality and / or versatility) of thes...

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Abstract

Processing a specimen in an automated tissue staining system includes robotically moving a slide carrier carrying slides each carrying a specimen at least partially embedded in paraffin into a stainer of the system. Liquid is automatically dispensed onto the slides according to predetermined protocols for at least deparaffinized, stained and contrast stained specimens. After the liquid has been dispensed automatically, the slide carrier can be moved robotically out of the stainer. In some embodiments, after moving the slide carrier into the stainer and before moving the slide carrier out of the stainer, the totality of all liquids dispensed onto the slide has a polyhydric concentration greater than the volume concentration of the monohydric alcohol. Alcohol volume concentration.

Description

technical field [0001] The present technology generally relates to automated tissue processing of biological specimens (eg, tissue samples), such as systems, devices, methods and compositions that enhance the quality, precision, efficiency, and / or other aspects of such processing. Background technique [0002] A wide variety of techniques can be used to analyze biological samples. Examples of analytical techniques useful in this context include microscopy, microarray analysis (eg, protein and nucleic acid microarray analysis), and mass spectrometry. Preparation of specimens for these and other types of analysis typically involves contacting the specimen with a series of processing fluids. Some of these processing fluids (eg, staining reagents and contrasting staining reagents) can increase color and contrast or otherwise alter invisible or poorly visible specimen components (eg, at least some types of cells and intracellular structures) visual characteristics. Other proce...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N1/31G01N1/30G01N35/00
CPCG01N1/30G01N1/312G01N2035/00138G01N35/00029G01N35/0099G01N35/1002G01N2001/302G01N2035/00039
Inventor C.A.克纳格C.威尔金森B.H.克拉姆C.维德纳D.钱皮翁E.杜兰特M.波拉斯克Z.沃辛斯卡K.奥罗斯茨H.巴内特
Owner VENTANA MEDICAL SYST INC
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