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Application of DFMO (difluoromethylomithine) or DFMO and ginger extract combination in preparation of drugs for prevention and clinical treatment of esophagus cancer and liver cancer

A clinical treatment, the technology of ginger extract, applied in the field of medicine, can solve the problems of activity loss, ODC structure change, etc., and achieve the effect of improving recurrence prevention and treatment effect

Inactive Publication Date: 2017-01-04
CHINA-US (HENAN) HORMEL CANCER INST
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Difluoromethylomithine (DFMO) is recognized as the most effective ODC-specific inhibitor and has anti-tumor effects in various tumors. It has a similar structure to ornithine and can be used as a substrate for ODC. Decarboxylation reaction, leading to irreversible structural changes of ODC and loss of activity

Method used

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  • Application of DFMO (difluoromethylomithine) or DFMO and ginger extract combination in preparation of drugs for prevention and clinical treatment of esophagus cancer and liver cancer
  • Application of DFMO (difluoromethylomithine) or DFMO and ginger extract combination in preparation of drugs for prevention and clinical treatment of esophagus cancer and liver cancer
  • Application of DFMO (difluoromethylomithine) or DFMO and ginger extract combination in preparation of drugs for prevention and clinical treatment of esophagus cancer and liver cancer

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Experimental program
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Embodiment

[0026] Materials and Methods

[0027] 1 material

[0028] 1.1 Tumor tissue

[0029] The present invention uses 2 cases of human esophagus cancer tissue samples. The two model numbers are EG5 and EG20 respectively. EG5 was obtained from the First Affiliated Hospital of Zhengzhou University, Henan Province, male, 61 years old. The postoperative pathological section showed: squamous cell carcinoma grade IIa, moderately differentiated I, no lymph node metastasis, and pathological stage: T2N0M0. EG20 was obtained from the First Affiliated Hospital of Zhengzhou University, Henan Province, male, 46 years old. The postoperative pathological section showed: squamous cell carcinoma grade II, moderately differentiated, no lymph node metastasis, and pathological stage: T2N0M0. The EG5 model used in the present invention is the 8th generation, and the EG20 is the 6th generation.

[0030] The present invention uses 2 cases of human liver cancer tissue samples. The case numbers are HHG9...

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Abstract

The invention relates to an application of DFMO (difluoromethylomithine) or DFMO and ginger extract combination in preparation of drugs for prevention and treatment of esophagus cancer and liver cancer and verifies that the DFMO or the DFMO and ginger extract combination has remarkable prevention and treatment effects on the esophagus cancer and the liver cancer on a PDX (patient derived xenograft) model. The DFMO or the DFMO and ginger extract combination is adopted to treat tumor-bearing mice, and when the tumor volume of a control group is up to 1,500 cubic millimeters or higher and an experiment is ended, the tumor volume of a mouse of a combined drug treatment group has remarkable statistic difference compared with that of the control group, so that the experiment indicates that the DFMO or the DFMO and ginger extract combination drugs can realize the remarkable prevention and treatment effects on the esophagus cancer and the liver cancer; the esophagus cancer and the liver cancer can be prevented and treated clinically through administration of the DFMO and ginger extract combination drugs to a patient.

Description

technical field [0001] The invention belongs to the field of medicine, and specifically relates to the application of DFMO or DFMO and ginger extract in the preparation of medicaments for the prevention and clinical treatment of esophageal cancer and liver cancer. Background technique [0002] Cancer has become the first cause of death in China and is a serious public health problem. According to statistical results, esophageal cancer and liver cancer are also the most common types of cancer in China and the most common cause of cancer death. Cancer is the result of the synergistic effect of environment, diet, lifestyle and genetic factors. The combination of carcinogens and cytogenetic factors leads to genetic mutations in cells and gradually develops into cancer. The clinical symptoms of cancer in the early stage are not obvious. When the clinical symptoms are more prominent, the patient's condition is already in the middle or late stage. Therefore, choosing safe and effe...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61K36/9068A61P35/00
CPCA61K31/198A61K36/9068A61K2236/33A61K2236/39A61K2236/55A61K2300/00
Inventor 董子钢刘康栋
Owner CHINA-US (HENAN) HORMEL CANCER INST
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