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Method for preventing overstimulation syndrome and application

A syndrome and new method technology, applied in the field of prevention and treatment of gynecological diseases, can solve the problems of increasing patients' physical discomfort and mental stress, increasing patients' treatment time and medical expenses, reducing the incidence of OHSS, etc., so as to eliminate physical discomfort and Effects of mental stress, avoiding medical disputes, and eliminating risks

Inactive Publication Date: 2017-01-04
陈薪
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although multi-channel symptomatic treatment can alleviate the patient's discomfort to a certain extent, it cannot completely avoid the occurrence of severe ovarian hyperstimulation syndrome, and severe OHSS significantly increases the patient's physical discomfort and mental stress. Increase the patient's treatment time and medical expenses, and may even cause serious medical disputes
[0004] The current international gold standard for the prevention of OHSS is "antagonist regimen plus gonadotropin releasing hormone agonist (GnRHa) to promote the final maturation of oocytes, and cancel fresh cycle embryo transfer", which is relatively The long-term ovulation induction program has significantly reduced the incidence of OHSS, especially moderate and severe OHSS, but it still cannot eliminate the occurrence of OHSS

Method used

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  • Method for preventing overstimulation syndrome and application
  • Method for preventing overstimulation syndrome and application

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Embodiment Construction

[0009] The present invention is further illustrated by specific examples.

[0010] 1. Case collection:

[0011] A total of 83 infertile women who underwent IVF antagonist program and were at high risk of OHSS were selected. GnRHa injection was given on the day of egg retrieval, and 0.2 mg triptorelin acetate for injection was given 12 hours after GnRHa injection. At the same time, Blood test for serum FSH, LH, E 2 , P and urine LH test paper detection. Embryo transfer was canceled in all patients. The basic characteristics of the patients are shown in Table 1. All patients had an average of 23.8 follicles ≥ 11 mm on the day of egg retrieval, and they were patients with ultra-high risk of OHSS.

[0012] surface 1 Patient characteristics

[0013]

[0014] 2. Treatment

[0015] All patients adopt antagonist ovulation induction scheme, low-dose gonadotropin for ovulation induction, and use the present invention after giving GnRHa on the egg retrieval day. The treatm...

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Abstract

The invention belongs to the field of gynecological disease prevention and treatment and relates to a new method for preventing overstimulation syndrome. The method is characterized by comprising the following steps: after injecting GnRHa for 12 hours according to an antagonist scheme, applying 0.2mg triptorelin acetate for injection; extracting blood and checking serum sex hormone and urine LH; after 24 hours, conventionally taking ovum, cancelling transplanting and utilizing transvaginal ultrasonography to closely examine the ovary size change of the patient. According to the invention, the operation is simple and convenient; the therapeutic effect is obvious; the serious OHSS risk of the patient caused by the OHSS ultrahigh risk can be obviously reduced and eliminated, so that the accordingly caused serious medical disputes can be avoided; uncomfortable body and mental stress caused by serious OHSS can be reduced and even eliminated; time and cost caused by other precautionary measures and hospitalization for preventing OHSS can be reduced; the safety of assisted fertility therapy can be obviously increased; the method can be widely applied to the assisted fertility therapy in the hospital.

Description

technical field [0001] The invention belongs to the field of prevention and treatment of gynecological diseases, and relates to a new method for preventing ovarian hyperstimulation syndrome (ovarian hyperstimulation syndrome, OHSS) in in vitro fertilization-embryo transfer (in vitro fertilization and embryo transfer, IVF-ET) and its Clinical application, it can be used in patients with high response to controlled ovulation stimulation in IVF cycle to prevent or even eliminate the occurrence of ovarian hyperstimulation syndrome. Background technique [0002] At present, due to the acceleration of the pace of work, the increasing pressure of job competition, and the combined influence of other factors such as environmental pollution, the number of infertility patients is increasing day by day. The use of hyperovulation stimulation in clinical work causes the patient to develop multiple follicles, and IVF-ET for conception has become an effective medical method, but the resulti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K38/09A61P15/08
Inventor 不公告发明人
Owner 陈薪
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