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Application of beta-sitosterol in preparing eimeria tenella resisting drug

A technology of Eimeria tenella and sitosterol is applied in the application field of beta-sitosterol in the preparation of anti-Eimeria tenella medicaments, and can solve the problem that the effect of anti-Eimeria tenella cannot be inferred, and the like, Achieving the effect of alleviating serious drug resistance problems, obvious effect, and speeding up research and development

Inactive Publication Date: 2017-02-22
广州市汇鑫动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] So far, there is no report that β-sitosterol has anti-Eimeria tenella, and it is impossible to infer whether it has an anti-Eimeria tenacia effect from the known properties of β-sitosterol

Method used

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  • Application of beta-sitosterol in preparing eimeria tenella resisting drug
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  • Application of beta-sitosterol in preparing eimeria tenella resisting drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Preparation of β-sitosterol powder: take 5g of β-sitosterol (content not less than 95%) and 95g of starch and mix well.

[0018] The usage and dosage of the powder: mix the above 100g powder into 100kg feed, and feed according to the daily food intake.

Embodiment 2

[0020] Preparation of β-sitosterol water-soluble powder: take 2.5g of β-sitosterol (content not less than 95%) and 97.5g of glucose and mix well.

[0021] Usage and dosage of water-soluble powder: dissolve the above-mentioned 100g powder in 100 liters of water. Cut off the water for 2 hours before the treatment, and then feed according to the normal drinking water amount.

Embodiment 3

[0023] The anti-chicken coccidiosis experiment of β-sitosterol is illustrated below in conjunction with specific experiments.

[0024] Experimental Materials:

[0025] Control drug: conventional anticoccidial drug Sanzi coccidian powder (30% sodium sulfachlorpyrazine, batch number 001010), produced by Shanghai Novartis Animal Health Co., Ltd.

[0026] β-sitosterol: the β-sitosterol powder of embodiment 1, the β-sitosterol water-soluble powder of embodiment 2.

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Abstract

The invention discloses an application of beta-sitosterol in preparing eimeria tenella resisting drug; the beta-sitosterol and acceptable assistant material are prepared to be dispersing agent, and added into fodder, evenly mixed and fed to chicken according to daily fodder quantity; or the beta-sitosterol is prepared to be beta-sitosterol water soluble powder, dissolved in water and fed to chicken according to daily fodder quantity. Through an animal infection experiment, it can be proved that the anticoccidial index (ACI) of beta-sitosterol can reach 180 above, and beta-sitosterol has good eimeria tenella resisting effect; compared with the regular anticoccidial drug sulfachloropyrazin, the beta-sitosterol has obvious anticoccidial effect. The invention can effectively release the serious drug resistance caused by using anticoccidial drug in current breeding industry; the research and development speed of new drug can be accelerated on this basis; besides, beta-sitosterol has important effect to green and health development of the breeding industry.

Description

technical field [0001] The invention relates to a new application of β-sitosterol, in particular to the application of β-sitosterol in the preparation of anti-Eimeria tenella medicaments. Background technique [0002] Chicken coccidiosis is the most important disease that seriously endangers the intensive chicken industry production, and the economic loss caused by it is as high as more than 2.5 billion pounds every year. Its pathogen is Eimeria spp of the apicomplexa class, The most harmful of these is Eimeria tenella. Chemical drug treatment is one of the important measures to control coccidiosis in chickens, but at present chicken coccidiosis has extensive and serious drug resistance, and new anticoccidiosis drugs are urgently needed to be put on the market. [0003] β-Sitosterol (Beta-Sitosterol), also known as (3β)-stigmaster-5-en-3-ol, sitosterol, mitesterol, etc., the molecular formula of this compound is C 29 h 50 O, molecular weight 414.71, CAS accession number: ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/575A61P33/02A23K50/75A23K20/105
CPCA61K31/575
Inventor 余永鹏张玉团覃润金
Owner 广州市汇鑫动物药业有限公司
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