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Application of genistein and its medicinal derivatives in the preparation of anti-Eimeria tenella medicaments

A technology of genistein and Eimeria, applied in the direction of application, drug combination, anti-infective drugs, etc., to achieve a good anti-Eimeria tenacia effect

Active Publication Date: 2019-04-30
INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no report that genistein has an anti-Eimeria tenabilis effect, and it is impossible to infer whether it has an anti-Eimeria tenacia effect based on the known properties of genistein

Method used

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  • Application of genistein and its medicinal derivatives in the preparation of anti-Eimeria tenella medicaments
  • Application of genistein and its medicinal derivatives in the preparation of anti-Eimeria tenella medicaments
  • Application of genistein and its medicinal derivatives in the preparation of anti-Eimeria tenella medicaments

Examples

Experimental program
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Effect test

Embodiment 1

[0044] Preparation of genistein powder: take 3 g of genistein (with a content of not less than 99%) and 97 g of soluble starch and mix well.

[0045] The usage and dosage of the powder: mix the above 100g powder into 100kg feed, and feed according to the daily food intake.

Embodiment 2

[0047] Preparation of genistein water-soluble powder: take 3 g of genistein (content not less than 99%) and 97 g of glucose and mix well.

[0048] Dosage of water-soluble powder: Dissolve 100g of the above-mentioned powder in 100 liters of water, and feed according to the normal amount of drinking water.

Embodiment 3

[0050] Preparation of genistein medicinal derivative water-soluble powder: take 3 g of genistein medicinal derivative (content not less than 99%) and 97 g of glucose and mix well.

[0051] Dosage of water-soluble powder: Dissolve 100g of the above-mentioned powder in 100 liters of water, and feed according to the normal amount of drinking water.

[0052] Taking genistein as a representative, the anti-coccidia effect of genistein and its medicinal derivatives will be described in combination with specific experiments.

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Abstract

The invention discloses genistein and an application of a medicinal derivative thereof in preparation of a medicine for resisting eimeria tenella. The genistein, after being uniformly mixed with an acceptable auxiliary material and added into a feed, can effectively resist the propagation of eimeria tenella in a chicken body. Compared with a conventional anti-coccidial drug namely dinitolmide premix, the anti-coccidial effect of the genistein is obvious. The genistein disclosed by the invention can effectively relieve the problem of serious drug tolerance generated by a current anti-coccidial drug used by the breeding industry, thereby accelerating research and development of a new medicine on the basis, and having important benefits for green and healthy development of the breeding industry.

Description

technical field [0001] The invention relates to a new application of genistein, in particular to the application of genistein in resisting Eimeria tenella. Background technique [0002] Chicken coccidiosis (Coccidiosis) is a disease caused by one or several coccidium of Eimeria (Eimeria) parasitizing in chicken intestinal mucosa cells simultaneously or successively. Coccidiosis occurs wherever chickens are raised in the world, and large-scale chicken farms are the most suitable places for chicken coccidiosis to occur, and outbreaks of the disease often occur. According to statistics, among the chicken coccidia reported in the world, 5 species have obvious pathogenicity, they are: E. tenella, E. necatrix, E. maxima, E. acervulina, and E. mitis. One of the most harmful is E.tenella. Chicks and young chickens are susceptible to coccidiosis, and the morbidity and mortality rates are as high as 80%. The growth of recovered chicks is hindered and the weight gain is slow; adult ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61P33/02A23K50/75A23K20/121
CPCA61K9/145A61K9/146A61K31/352
Inventor 吴彩艳李娟孙铭飞廖申权戚南山吕敏娜林栩慧
Owner INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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