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Optic detector based on electric control magnet enrichment-separation and total internal reflection magnetic imaging

An optical detector and optical detection technology, applied in the field of optical detectors, can solve problems such as high professional level requirements, large detection instruments, and small application range, and achieve the effects of improving reaction speed, simplifying detection steps, and expanding application range

Inactive Publication Date: 2017-04-26
INST OF ELECTRONICS CHINESE ACAD OF SCI
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Problems solved by technology

[0007] For the detection of low-concentration substances in trace samples such as blood samples, the existing detection instruments have the limitations of too large detection instruments and many detection steps; especially for microalbumin and its lower concentration protein substances and cells, etc. When the operation steps are complicated, it is not suitable for rapid detection, and the scope of application is very small; and the multi-step detection steps involved require a high professional level, which greatly limits the use of non-professionals

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  • Optic detector based on electric control magnet enrichment-separation and total internal reflection magnetic imaging
  • Optic detector based on electric control magnet enrichment-separation and total internal reflection magnetic imaging
  • Optic detector based on electric control magnet enrichment-separation and total internal reflection magnetic imaging

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Embodiment Construction

[0033] In order to make the objectives, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with specific embodiments and with reference to the accompanying drawings.

[0034] figure 1 It is a schematic diagram of an embodiment of the optical detector of the present invention, such as figure 1 As shown, the optical detector of this embodiment mainly includes the following structures: electronically controlled magnetic enrichment-separation structure, total internal reflection magnetic imaging optical detection structure, constant temperature heating circuit 1-11, main control circuit 1-12, and indicating device 1. -13, host computer 1-14, etc.

[0035] Among them, the electronically controlled magnetic enrichment-separation structure includes: detection chip 1-1, upper electromagnetic coil 1-5, lower electromagnetic coil 1-6, electromagnetic control circuit 1-10, etc., in which the detect...

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Abstract

The invention discloses an optic detector based on an electric control magnet enrichment-separation structure and a total internal reflection magnetic imaging structure, and relates to the technical field of biomedical detection. Currently, due to the fact that a detection instrument for low-concentration substances is too large in size, complicated in procedure, long in detection time, and has high demands for professional technology, and thus application of the detection instrument is greatly restricted. Therefore, the electric control magnet enrichment-separation structure and the total internal reflection magnetic imaging structure are combined so that a biochemical sampling testing device which is efficient, convenient, precise, and is applicable to operation of non-professional staff is achieved, and the optic detector has big significance in the technical filed of biomedical detection.

Description

Technical field [0001] The invention relates to the technical field of biomedical detection, in particular to an optical detection instrument based on an electronically controlled magnetic enrichment-separation structure and a total internal reflection magnetic imaging optical detection structure. Background technique [0002] The detection of low-concentration substances in samples, especially blood samples, usually adopts immunoassay technology. In order to reduce interference, the blood sample needs to be centrifuged to remove blood cells and other pre-processing steps, which increase the detection time and detection steps; in order to increase the detection Accuracy and sensitivity. Many immune reactions use magnetic particle separation technology to separate low-concentration test substances from samples. It is also necessary to separate composite magnetic particles by centrifugation and wash them. The detection sensitivity is high, but the steps are complicated. The instrum...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/55G01N21/01
CPCG01N21/55G01N21/01
Inventor 刘春秀贾建蔡浩原刘昶
Owner INST OF ELECTRONICS CHINESE ACAD OF SCI
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