Pharmaceutical composition for treating idiopathic pulmonary fibrosis and application of such pharmaceutical composition
A technology for pulmonary fibrosis and a composition is applied in the field of pharmaceutical compositions for the treatment of idiopathic pulmonary fibrosis, which can solve the problems of large toxic and side effects, poor treatment effect, etc., and achieves no toxic and side effects, wide application value, and difficulty in recurrence. Effect
Inactive Publication Date: 2017-05-10
ZHENGZHOU ZHANGMENG NETWORK TECH CO LTD
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AI Technical Summary
Problems solved by technology
However, the above-mentioned drugs for the treatment of idiopathic pulmonary fibrosis have disadvantages such as poor therapeutic effect and relatively large toxic and side effects.
Method used
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Comparison scheme
Effect test
Embodiment 1
[0015] In the embodiment of the present invention, a pharmaceutical composition for treating idiopathic pulmonary fibrosis is composed of nafamostat and artesunate, wherein the mass ratio of nafamostat and artesunate is 1.6:1.
Embodiment 2
[0017] In the embodiment of the present invention, a pharmaceutical composition for treating idiopathic pulmonary fibrosis is composed of nafamostat and artesunate, wherein the mass ratio of nafamostat and artesunate is 2.4:1.
Embodiment 3
[0019] In the embodiment of the present invention, a pharmaceutical composition for treating idiopathic pulmonary fibrosis is composed of nafamostat and artesunate, wherein the mass ratio of nafamostat and artesunate is 1.8:1.
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The invention discloses a pharmaceutical composition for treating idiopathic pulmonary fibrosis and application of such pharmaceutical composition. The pharmaceutical composition is prepared by compositing nafamostat and artesunate in a mass ratio of 1.6-2.4:1. Administration dosage for adults is 0.45-0.50mg / kg / day when the pharmaceutical composition is used for treating idiopathic pulmonary fibrosis. Clinical experiments show that the pharmaceutical composition is remarkably effective in treatment of acute idiopathic pulmonary fibrosis, subacute idiopathic pulmonary fibrosis, chronic idiopathic pulmonary fibrosis and acute onset of chronic idiopathic pulmonary fibrosis, reaches the total effective rate of 92-96%, and is capable of avoiding proneness to relapse and free of toxic or side effect, thereby being high in application value.
Description
technical field [0001] The invention relates to the technical field of medicines, in particular to a medicine composition for treating idiopathic pulmonary fibrosis and its application. Background technique [0002] Idiopathic pulmonary fibrosis (IPF) is one of the chronic interstitial lung diseases of unknown etiology, and it is also a chronic inflammatory lung disease characterized by pathological changes of common interstitial pneumonia. The pathogenesis is still not very clear. In 2000, the American Thoracic Society and the European Respiratory Society jointly issued an international joint statement to clearly define idiopathic pulmonary fibrosis, believing that idiopathic pulmonary fibrosis is an independent disease, and its pathomorphological manifestations are Usual interstitial pneumonia (UIP) is different from other idiopathic interstitial pneumonias, such as desquamative interstitial pneumonia (DIP), acute interstitial pneumonia (AIP), nonspecific interstitial pne...
Claims
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Login to View More IPC IPC(8): A61K31/357A61K31/245A61P11/00
CPCA61K31/357A61K31/245
Inventor 不公告发明人
Owner ZHENGZHOU ZHANGMENG NETWORK TECH CO LTD