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Application of radix ophiopogonis sapogenin in preparation of medicine for tissue factor mediated diseases

A technology of tissue factor and Ophiopogon japonicus, applied in the field of drug application, can solve problems such as unclear DVT

Inactive Publication Date: 2017-05-31
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But how these factors lead to DVT is still not well understood

Method used

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  • Application of radix ophiopogonis sapogenin in preparation of medicine for tissue factor mediated diseases
  • Application of radix ophiopogonis sapogenin in preparation of medicine for tissue factor mediated diseases
  • Application of radix ophiopogonis sapogenin in preparation of medicine for tissue factor mediated diseases

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Experimental program
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Effect test

Embodiment 1

[0035] Inhibitory Effect of Ophiopogongenin on TNF-α-Induced Tissue Factor in HUVECs

[0036] Sample: Ophiopogon sapogenin and saponins, the structure is as follows:

[0037]

[0038]

[0039]

[0040]

[0041]

[0042]

[0043]

[0044]

[0045] Each compound of the present invention can be isolated from natural products, or obtained through further chemical synthesis, structural modification and biotransformation. Among them, N1, N2, and N3 can be obtained from Liriope muscari (Decne.) Baily, Liriope spicata (Thunb.) Lour.var.prolifera Y.T.M a), Liriope spicata (Thunb.) Lour.var. It is isolated from plants such as Liriope graminifolia (Linn.) Baker), Ophiopogon japonicus (L.f) KerGawl., and plants such as Ruscus aculeatus of Asparagaceae. JM6-1 and JM6-2 can be isolated from the total saponin hydrolyzate of plants such as Agave sisalana Perr.ex Engelm. in the family Agaveaceae. RUSN2 and SYH can be obtained by structural modification of N1 and Diosg...

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Abstract

The invention provides an application of radix ophiopogonis sapogenin in the preparation of medicine for tissue factor mediated diseases. The radix ophiopogonis sapogenin is used for preparing medicine for resisting thrombus, treating pulmonary embolism and acute lung injury, resisting atherosclerosis and preventing tumor angiogenesis. According to the invention, the radix ophiopogonis sapogenin realizes a remarkable inhibitory effect on TNF-alpha induced HUVECs cell tissue factor and can be used for preparing medicine for tissue factor mediated diseases.

Description

technical field [0001] The invention belongs to the technical field of natural medicines, and specifically relates to the application of ophiopogonin in preparing medicines for tissue factor-mediated diseases. Background technique [0002] Tissue factor (TF), also known as coagulation factor III, thromboplastin or thromboplastin (CD142), is a single-chain transmembrane glycoprotein. TF is not only the receptor of coagulation factor VII on the cell surface, but also the cofactor of FVII or activated factor VII (FVIIa). It is the only coagulation factor that exists in cells and tissues other than normal human plasma. TF is the initiator of extrinsic coagulation pathway. When blood vessels are damaged, endothelial cells and vascular smooth muscle cells receive various stimuli, which can induce blood coagulation. The modern coagulation theory holds that the tissue factor pathway, that is, the exogenous pathway, is the main pathway of physiological coagulation. The complex of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61P7/02A61P11/00A61P9/10A61P35/00
CPCA61K31/58
Inventor 余伯阳赵亚铮张媛媛寇俊萍戚进吴炎
Owner CHINA PHARM UNIV
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