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A use, the technology of oxiracetam, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, allergic diseases, etc., can solve the problems of allergic rhinitis that cannot be cured, dry mouth, poor tolerance of patients, etc.

Active Publication Date: 2019-08-09
BRIGHTGENE PHARMA
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Problems solved by technology

Although the current application of corticosteroids is considered relatively safe, allergic rhinitis cannot be cured and requires long-term medication. Long-term use of corticosteroids still has certain risks
Loratadine is often used as a first-line drug for the treatment of mild allergic rhinitis, but it has side effects such as dry mouth, so some patients have poor tolerance, and more effective drugs for the treatment of allergic rhinitis are needed clinically

Method used

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Embodiment Construction

[0014] The content of the invention will be further explained and illustrated below in conjunction with specific examples, but they do not constitute a limitation or limitation on the scope of the invention.

[0015] 1 Materials and methods

[0016] 1.1 Materials

[0017] Hartley guinea pigs, male, 6-8 weeks old, weighing (200±50) g ​​(purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.). Oxiracetam (produced by our company); ovalbumin (Ovalbumin, OVA, purchased from Sigma); aluminum hydroxide gel (purchased from Thermoscientific, USA). 1.2 Method

[0018] 1.2.1 Establishment of guinea pig allergic rhinitis model

[0019] 36 guinea pigs were randomly divided into three groups, the first group was the normal control group (control group, n=12), the second group was the allergic rhinitis model establishment group (model group, n=12), the third group was the treatment drug Oxiracetam group (drug group, n=12).

[0020] In the first group, 0.1 ml of n...

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Abstract

The invention provides an application of oxiracetam in preparation of a drug for treating allergic rhinitis. The invention further provides a pharmaceutical preparation. The pharmaceutical preparation contains the oxiracetam and a pharmaceutically acceptable carrier, wherein the pharmaceutical preparation can be the dosage forms such as a tablet, a capsule and a nasal spray. According to the pharmaceutical preparation, the content of the oxiracetam in each preparation unit is 0.01-1,000mg. Meanwhile, the invention provides an application of the pharmaceutical preparation in preparation of the drug for treating allergic rhinitis.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a new application of oxiracetam, more specifically, relates to a new application of oxiracetam in treating allergic rhinitis. Background technique [0002] Oxiracetam, chemical name 2-(4-hydroxy-2-oxopyrrolidon-1-yl)acetamide, molecular formula C 6 h 10 N 2 o 3 , molecular weight 158.16. Oxiracetam is a compound that can promote phosphorylcholine, phosphorylethanolamine and brain metabolism. Long-term use of drugs containing this compound by the elderly can significantly improve tissue function and memory impairment, especially for the prevention and treatment of senile dementia. Significant effect. Drugs containing these compounds are also used in the treatment of senile cerebral insufficiency syndrome and mental behavioral disorders. [0003] With the increasing cost of new drug research and development year by year, how to discover new uses of "old drugs" is a topic for medical res...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4015A61P37/08A61P11/02
CPCA61K31/4015
Inventor 袁建栋
Owner BRIGHTGENE PHARMA
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