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Application of caffeic acid phenethylester for preparing pharmaceutical for reinforcing learning and memory ability

A technology of phenethyl caffeate and enhanced learning, which is applied in the field of medicine and can solve problems that have not been reported in the literature and affect memory ability

Inactive Publication Date: 2017-09-08
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the application of phenethyl caffeate mainly focuses on anti-tumor, liver protection, anti-ischemia-reperfusion injury, antibacterial, etc. The Protective Effect of Lipid Peroxidation Damage" discloses that phenethyl caffeate has a strong antioxidant effect, and the oxidative damage caused by oxidative stress is an important factor leading to the gradual death of nerve cells, thereby affecting memory ability
But it is aimed at nerve cells with oxidative damage, and there is no literature report on the application of caffeic acid phenethyl ester in enhancing the learning and memory ability of normal mice or humans

Method used

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  • Application of caffeic acid phenethylester for preparing pharmaceutical for reinforcing learning and memory ability
  • Application of caffeic acid phenethylester for preparing pharmaceutical for reinforcing learning and memory ability
  • Application of caffeic acid phenethylester for preparing pharmaceutical for reinforcing learning and memory ability

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1 Platform jump experiment

[0013] The experimental principle of the platform experiment: in a light-proof platform box with electric field stimulation, a rubber platform is arranged in each interlayer. On this rubber table, mice are not stimulated by electric shocks. And because mice have a natural tendency to move downward, they like to jump on the electric grid underneath which is stimulated by the electric field. But after repeated training, mice with strong memories learned that the grid was live and therefore did not jump off. Mice with poor memory will often jump and fall, which increases the number of mistakes. Put the mice in the light-proof platform box, and the time when they jump off the grid for the first time is used as the escape latency, which can reflect the memory ability of the mice. The platform jump test can not only observe the influence of drugs on the memory process, but also observe the influence on learning, and has a high sensit...

Embodiment 2

[0016] Example 2 Dark avoidance experiment

[0017] The dark avoidance experiment is a memory experiment designed based on the principle that mice like dark places. The whole device is composed of two boxes, one is a dark box that is protected from light but has an electric grid inside, every time the experimental animal enters this dark box, it will be stimulated by the electric field, but there is no grid stimulation in the bright box. Among them, the stimulation of electric field is stronger than the stimulation of light brightness. The data that needs to be recorded in the experiment is the wrong number of times the mouse entered the electrified dark box by mistake, and the latency time of entering the dark box for the first time. The more times of entering the dark box and the shorter the latency period, the poorer the memory of the mice. The dark avoidance test is designed by using the dark habit of mice, which belongs to the passive avoidance response. The latency and...

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Abstract

The invention discloses an application of caffeic acid phenethylester for preparing a pharmaceutical for reinforcing a learning and memory ability. The effective ingredient of the pharmaceutical for reinforcing the learning and memory ability comprises the caffeic acid phenethylester. A grouping comparison test is executed to ICR mice, and the error frequency of the incubation period and the observation period of the normal ICR mice is counted through a step-down test and a dark avoidance test, so the application field of the caffeic acid phenethylester is broadened.

Description

technical field [0001] The invention relates to the application of caffeic acid phenethyl ester in the preparation of medicines for enhancing learning and memory, and belongs to the technical field of medicine. Background technique [0002] Learning and memory ability is one of the most basic functions of the human brain. It is a lifelong adaptation process of the brain's neural circuits to environmental changes, enabling the body to properly respond to various events it encounters. The human body survives by learning and changing its behavior to adapt to the environment; memory is necessary for normal life and work. Memory depends on the integrity of normal neuron function, and normal people will have a moderate decline in memory as they age. Moreover, due to social competition, the young people are under increased pressure in life and work, and there is a phenomenon of learning and memory loss. Therefore, the development of drugs that enhance learning and memory function...

Claims

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Application Information

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IPC IPC(8): A61K31/216A61P25/28
CPCA61K31/216
Inventor 吴亮何玲汪小燕许心心王呈呈廖有为胡蝶陈星光王雨轩牟畅李成婧崔雪婷俞婧婷丁赣成汪豪纪红张陆勇
Owner CHINA PHARM UNIV
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