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Experimental rat fixator for suction type intratracheal instillation

A kind of experimental mouse and inhalation technology, which is applied in veterinary equipment, animal restraint equipment, medical science, etc., can solve problems such as cognitive impairment, blood sugar rise, inhalation lung limitation, etc., to eliminate interference and prevent mice Struggling, easy-to-operate effects

Inactive Publication Date: 2017-09-19
HAINAN MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After reviewing the literature, it was found that ether can promote the release of catecholamines, resulting in an increase in blood sugar. As an anesthetic, ether can cause cognitive impairment. Therefore, ether exposure may affect the experimental results of the blood system and nervous system of rats. Toxicity studies on experimental animals, especially the nervous system Caused a certain impact, and animals under anesthesia are limited in actively breathing instillation into the lungs

Method used

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  • Experimental rat fixator for suction type intratracheal instillation
  • Experimental rat fixator for suction type intratracheal instillation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Such as Figure 1-Figure 2 As shown, a laboratory mouse holder for inhalation tracheal instillation includes a base plate 1 and a column 2 fixed on the base plate 1, and the column 2 is connected with a telescopic rod 9 and a fixed cross bar 7 arranged up and down. , the telescopic rod 9 is connected with a hook line 10 for hanging the incisors of the experimental mouse, and the fixed cross bar 7 is provided with a fixed bayonet 8 for clamping the experimental mouse, and the fixed bayonet 8 includes two openings facing inward. The arc splint 81, the two ends of the arc splint 81 are respectively set to connect the straight plate portion 82 and adjust the straight plate portion 83, the arc splint 81 is connected with the fixed cross bar 7 through the connecting straight plate portion 82, and the two arc splints The adjustment straight plate parts 83 of 81 are connected through at least one adjustment screw rod 84, and the two ends of the adjustment screw rod 84 are provi...

Embodiment 2

[0031] On the basis of a kind of experimental mouse fixer for inhalation tracheal instillation described in embodiment 1, further optimization, at least one of the telescopic rod 9 and the fixed cross bar 7 is connected to the column 2 by rotation, the present invention The setting of the embodiment facilitates the adjustment of the position of the hook line 10, so that the hook line 10 is vertically arranged above the oral cavity of the experimental rat, so as to avoid straining the experimental rat.

Embodiment 3

[0033] On the basis of a kind of experimental mouse holder for inhalation tracheal instillation described in Example 1, it is further optimized. Pull the rat upwards to control the mouth opening of the rat.

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Abstract

The invention discloses an experimental rat fixator for suction type intratracheal instillation and relates to the field of animal experimental auxiliary devices. The fixator comprises a bottom plate and a column fixed on the bottom plate. The column is connected to a telescopic rod and a fixed transverse rod which are arranged up and down; the telescopic rod is connected to a hook line which hangs the incisor of an experimental rat; a fixed bayonet for clamping the experimental rat is formed in the fixed transverse rod; the fixed bayonet comprises two arc-shaped clamping plates, the openings of which face inward; the two ends of the arc-shaped clamping plates are separately arranged as connecting straight plate portions and adjusting straight plate portions; the arc-shaped clamping plates are rotatably connected to the fixed transverse rod through the connecting straight plate portions; the adjusting straight plate portions of the two arc-shaped clamping plates are connected through at least one adjusting screw; and adjusting caps for adjusting the distance between the two arc-shaped clamping plates sleeve at two ends of the adjusting screws; an arc-shaped flexible rubber base plate, the opening of which faces inward, is attached to the inner wall of each of the arc-shaped clamping plates, a flexible rubber placing portion is arranged on the lower end of each of the arc-shaped flexible rubber base plates, and the flexible rubber placing portion is of a trumpet shape which is opened downward.

Description

technical field [0001] The invention relates to the field of animal experiment auxiliary devices, in particular to an experimental mouse fixer for inhalation-type tracheal instillation. Background technique [0002] Respiratory inhalation is an important contact route for harmful substances to enter the body, and it is a commonly used research method in the fields of occupational medicine, environmental medicine and toxicology. In 1923, Kimura first studied the tumorigenicity of coal tar on rabbits and guinea pigs by tracheal instillation. Since the 1970s, tracheal instillation has been widely used. According to whether the trachea is exposed, the tracheal instillation method can be divided into two types: non-exposed and exposed. The exposed tracheal instillation method refers to cutting the skin and muscle of the neck of the experimental animal to expose the trachea, and then inserting the micro sample injector into the trachea, the accuracy of the experiment is guarante...

Claims

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Application Information

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IPC IPC(8): A61D3/00
CPCA61D3/00A61D2003/003
Inventor 燕贞梁肖谢毅强刘云儒杨建军秦燕
Owner HAINAN MEDICAL COLLEGE
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