Etamsylate induced rat hypercoagulable state animal model and establishment method thereof

A technology for constructing methods and animal models, applied in the field of experimental zoology, can solve the problems of availability, non-availability, unfavorable long-term observation, etc., and achieve the effects of long duration, high model success rate and simple operation.
CN107308151AActive Publication Date: 2017-11-03BEIJING NORMAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING NORMAL UNIVERSITY
Publication Date
2017-11-03

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Abstract

The invention discloses an etamsylate induced rat hypercoagulable state animal model and an establishment method thereof. According to the model, etamsylate is adopted for interference, three times of intraperitoneal injection are implemented, then a hypercoagulable state is achieved within 1.5-9 hours, the operation is simple, the model success rate is high, and the hypercoagulable state can last for a relatively long time. The rat hypercoagulable state animal model based on an etamsylate medicine is successfully established, a base for related rat hypercoagulable state research is made, and the establishment method is a novel rat hypercoagulable state animal model method.
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Description

technical field

[0001] The invention relates to an animal model of hypercoagulation state of rats induced by ethanamine and a construction method thereof, belonging to the field of experimental zoology. Background technique

[0002] The hypercoagulable state, also known as the pre-thrombotic state, refers to a state in which the body exhibits an increased tendency to coagulate blood. It is generally believed that the emergence of hypercoagulable state is related to the serious abnormality of the coagulation function of the coagulation system, and the reasons are complex and diverse. There is also a view that hypercoagulable states can be divided into hereditary hypercoagulable states and acquired hypercoagulable states. Hereditary hypercoagulability is due to specific genetic mutations that lead to thrombosis, the onset age is relatively low, and the site of thrombosis is relatively special. In terms of general pathological distribution, the range of acquired hypercoagulab...

Claims

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