Tamoxifen gel paste and preparation method thereof

A technology of moxifen gel patch and tamoxifen, which is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve allergies, and there is no tamoxifen Fen gel paste, skin irritation and other problems, to achieve good air permeability, avoid venous thrombosis and susceptibility to endometrial cancer, reduce irritation
CN108210484AActive Publication Date: 2018-06-29FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
FUDAN UNIV
Publication Date
2018-06-29

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Abstract

The invention belongs to the technical field of pharmaceutic preparations, and relates to tamoxifen gel paste and a preparation method thereof. The invention provides the tamoxifen gel paste. The tamoxifen gel paste is prepared from the following components in parts by weight: tamoxifen, solubilizers, a crosslinking type polymer, a crosslinking agent, a crosslinking adjuster and carbomer. By adding the carbomer, the problem of forming of a gel paste matrix is effectively improved; by adding the eucalyptus oil and the diethylene glycol monoethyl ether which are the solubilizers, the solubilityof the tamoxifen in the gel paste matrix is obviously improved, and the problem of drug precipitation is solved. The tamoxifen gel paste prepared through the preparation method disclosed by the invention is stably formed and intact in appearance, has the advantages of high adhesive capacity, high percutaneous penetration rate, no allergenicity, no irritation, convenience in use, no pollution to clothes, low production cost and the like, and can be repeatedly torn down and pasted on.
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Claims

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