55 results about "Percutaneous penetration" patented technology

The present invention provides systems, apparatus and methods for selectively applying electrical energy to body tissue. More specifically, systems and methods are provided for introducing a spinal cord stimulation electrode device into a patient's epidural space through a small portal, such as a percutaneous penetration, and then expanding the electrode device once inside the epidural space to achieve a larger footprint of contact on the dura. This substantially prevents migration of the electrode within the epidural space and provides for more efficient and effective treatment.

The invention provides devices and methods for performing less-invasive surgical procedures within an organ or vessel. In an exemplary embodiment, the invention provides a method of closed-chest surgical intervention within an internal cavity of a patient's heart or great vessel. According to the method, the patient's heart is arrested and cardiopulmonary bypass is established. A scope extending through a percutaneous intercostal penetration in the patient's chest is used to view an internal portion of the patient's chest. An internal penetration is formed in a wall of the heart or great vessel using cutting means introduced through a percutaneous penetration in an intercostal space in the patient's chest. An interventional tool is then introduced, usually through a cannula positioned in a percutaneous intercostal penetration. The interventional tool is inserted through the internal penetration in the heart or great vessel to perform a surgical procedure within the internal cavity under visualization by means of the scope. In a preferred embodiment, a cutting tool is introduced into the patient's left atrium from a right portion of the patient's chest to remove the patient's mitral valve. A replacement valve is then introduced through an intercostal space in the right portion of the chest and through the internal penetration in the heart, and the replacement valve is attached in the mitral valve position.

Devices, systems and methods for applying electrical impulse(s) to one or more selected nerves in or around the carotid sheath are described. An electrode assembly is introduced through a percutaneous penetration in a patient to a target location adjacent to, or in close proximity with, the carotid sheath. Once in position, one or more electrical impulses are applied through the electrode assembly to one or more selected nerves to stimulate, block or otherwise modulate the nerve(s) and acutely treat the patient's condition.

The invention provides devices and methods for performing less-invasive surgical procedures within an organ or vessel. In an exemplary embodiment, the invention provides a method of closed-chest surgical intervention within an internal cavity of a patient's heart or great vessel. According to the method, the patient's heart is arrested and cardiopulmonary bypass is established. A scope extending through a percutaneous intercostal penetration in the patient's chest is used to view an internal portion of the patient's chest. An internal penetration is formed in a wall of the heart or great vessel using cutting means introduced through a percutaneous penetration in an intercostal space in the patient's chest. An interventional tool is then introduced, usually through a cannula positioned in a percutaneous intercostal penetration. The interventional tool is inserted through the internal penetration in the heart or great vessel to perform a surgical procedure within the internal cavity under visualization by means of the scope. In a preferred embodiment, a cutting tool is introduced into the patient's left atrium from a right portion of the patient's chest to remove the patient's mitral valve. A replacement valve is then introduced through an intercostal space in the right portion of the chest and through the internal penetration in the heart, and the replacement valve is attached in the mitral valve position.

The invention is directed to a system and method for releasably holding a surgical instrument (14), such as an endoscopic instrument configured for delivery through a small percutaneous penetration in a patient. The instrument comprises an elongate shaft (100) with a pair of mounting pins (116) laterally extending from the shaft between its proximal and distal ends. An instrument holder comprises a support having a central bore (202) and an axially extending slot (204) for receiving the instrument shaft and the mounting pins. A pair of locking slots (206) are cut into the support transversely to and in communication with the axial slot so that the mounting pins can be rotated within the locking slots. The instrument support further includes a latch assembly for automatically locking the mounting pins within the locking slots to releasably couple the instrument to the instrument holder. With this twist-lock motion, the surgeon can rapidly engage and disengage various instruments from the holder during a surgical procedure, such as open surgery, laparoscopy or thoracoscopy.

The disclosure is directed to a medical robotic system and method for releasably securing a medical instrument over a modular support assembly that is further removably coupled to the manipulating arm via an intermediate fastening component. The medical instrument is configured for delivery through a small percutaneous penetration in a patient as it slides over the modular support assembly, independent of the manipulating arm. The robotic system further includes a simplified draping mechanism including covering the manipulating arm up to the fastening component thereby obviating the need for extensive sterile drape that extends all over the arm up to the support interface and the cannula holding assembly in existing art. Advantageously, the present invention allows for a quick and simple installation while allowing for free rotary motion of the support assembly.

A pre-assembled, telescoping needle system comprising an outer needle surrounding a finer gauge needle which, after percutaneous penetration by the outer needle, extends to penetrate the intervertebral disc into which the injectable is to be delivered.

The invention belongs to the technical field of medicines, and provides a propranolol hydrochloride (PPL.HCL) gel which can be externally used for treating infant superficial hemangioma. The propranolol hydrochloride gel is mainly prepared from propranolol hydrochloride, gel matrix, a percutaneous penetration enhancer, a preservative, a humectant and the like. By using the propranolol hydrochloride gel, adverse reactions such as decreased heart rate, cyanosis, airway hyperresponsiveness, shortage of granular leukocytes, diarrhoea, sleep change and blood sugar reduction caused by orally taking propranolol by hemangioma patients can be reduced and even avoided, and the problems that oral dosage is not easy to control, infants inconveniently take medicines and the like are solved.

The invention relates to a skin aging resistance traditional Chinese medicine cosmetic composition, which is prepared by adding three traditional Chinese medicine extracts such as a ginseng extract, a dendrobium extract and clove volatile oil to a cosmetic matrix. The production method comprises: heating the three traditional Chinese medicine extracts to a temperature of about 80 DEG C, and then mixing the heated three traditional Chinese medicine extracts and a pretreated cosmetic matrix to prepare the traditional Chinese medicine cosmetic. According to the present invention, percutaneous penetration experiment results show that ginsenosides (Rg1, Rb1 and Re) having definite anti-oxidation and aging delaying effects and eugenol in the series of the traditional Chinese medicine cosmetic can penetrate through skin, and the clove volatile oil is adopted as the permeation promoter so as to increase the permeation amount of the ginsenoside components; and with the percutaneous penetration experiment, the material basis assurance is provided for provision of treatment effects of various effective components after entering skin.

The invention discloses a bullatacin ethosome gel and a preparation method thereof. The bullatacin ethosome gel comprises ethosomes and a gel, wherein the ethosomes and the gel exit in a uniformly mixed state; the ethosomes are particles containing bullatacin, phospholipids, low-molecular weight alcohols, cholesterol, stabilizers, antioxidants and water; the particle size of the ethosomes ranges from 30 nm to 400 nm; the gel contains a gel matrix, penetration enhancers, humectant, antiseptics, pH regulators and water; and the ethosomes and the gel are combined at a certain weight ratio, and the ethosomes and the gel have specific compositions respectively. The bullatacin ethosome gel provided by the invention can reduce irritation to the skin and has good percutaneous penetration effects.

Upon allowing a medicine 1 containing an active ingredient to penetrate an organism 2 from a skin surface 2a, this ultrasonic percutaneous penetration device A allows vibration of ultrasonic waves to penetrate the organism from the skin surface. This device is provided with an irradiation unit 4 that applies ultrasonic waves having a frequency of not less than 0.5 MHz from skin 2a or a surface capable of contacting the medicine, and a control unit 3 that controls irradiation conditions of the irradiation unit.

The invention relates to an internal fixing device for minimally-invasive percutaneous penetration. The internal fixing device comprises a minimally-invasive holding sleeve and a minimally-invasive pedicle screw. The minimally-invasive holding sleeve is composed of a minimally-invasive casing pipe, a locking sleeve, a sliding groove pin, a locking screw and an anti-rotation pin. The minimally-invasive pedicle screw is composed of a screw cap, a screw body and a pressing washer. A horizontal protrusion of the inner wall of the front end of the minimally-invasive holding sleeve and the anti-rotation pin are matched with a cross-shaped groove of the outer side of the screw cap of the minimally-invasive pedicle screw, so that the multi-direction movement of the screw is limited. Automatic bar pressing can be achieved in an operation through the lengthening design of the screw cap of the minimally-invasive pedicle screw, bar penetrating is simple, the protrusion of the outer side of the minimally-invasive holding sleeve and the elastic design are utilized to lock the screw in the use process, and the screw is reinforced and fixed through the locking screw. The internal fixing device has the advantages that as the unique design of the inner wall of the minimally-invasive holding sleeve is matched with the cross-shaped groove of the outer side of the screw cap of the minimally-invasive pedicle screw, screw holding and dismantling operation is simple, fast and effective; due to the design of the two thin walls of the front end of the holding sleeve, trauma of tissue channels is small; the problems of difficulty of bar penetrating and complexity of locking and pressurizing of the screw cap and the like in the operation can be solved.

A percutaneous dilation apparatus is shown. The apparatus is useful for forming and enlarging percutaneous penetrations to a variety of target locations within a patient's body for multiple purposes. The apparatus includes an at least one dilator segment, a dilator probe, and a mechanism for moving each dilator segment along the dilator probe so as to place it within the penetration thereby dilating the penetration.

The invention belongs to the technical field of medicines, and provides a propranolol hydrochloride (PPL.HCL) gel which can be externally used for treating infant superficial hemangioma. The propranolol hydrochloride gel is mainly prepared from propranolol hydrochloride, gel matrix, a percutaneous penetration enhancer, a preservative, a humectant and the like. By using the propranolol hydrochloride gel, adverse reactions such as decreased heart rate, cyanosis, airway hyperresponsiveness, shortage of granular leukocytes, diarrhoea, sleep change and blood sugar reduction caused by orally taking propranolol by hemangioma patients can be reduced and even avoided, and the problems that oral dosage is not easy to control, infants inconveniently take medicines and the like are solved.

The invention provides a system and method for performing less-invasive surgical procedures within a body cavity. In a preferred embodiment, the invention provides a system and method for isolating a surgical site such as an anastomosis between an internal mammary artery and a coronary artery in a thoracoscopic coronary artery bypass grafting procedure. The system comprises a foot (11) pivotally coupled to the distal end of a shaft (3) by a linkage (13). The foot has first and second engaging portions (15, 17) with contact surfaces for engaging a tissue surface. The engaging portions are movable between an open position, where the contact surfaces are separated by a gap, and a collapsed position, where the foot is configured for delivery through the percutaneous penetration. An actuator, at the proximal end of the shaft, can be rotated to pivot the foot about a transverse axis so that the contact surfaces are oriented generally parallel to the surgical site to apply pressure to the tissue structure on both sides of the surgical site.

A percutaneous penetration enhancing apparatus includes a sheet member capable of being placed on a skin; a plurality of skin condition sensors arranged on the sheet member, each of the plurality of skin condition sensors detecting information related to a condition of the skin; and a plurality of percutaneous penetration enhancing elements arranged on the sheet member, each of the plurality of percutaneous penetration enhancing elements being operated on the basis of the information detected by one or more of the plurality of skin condition sensors.

The invention relates to a soluble micro-needle containing slightly-soluble contraceptives and a preparation method of the soluble micro-needle. The soluble micro-needle comprises a base and a needle tip, wherein the needle tip is prepared by a cyclodextrin inclusion compound, a micro-needle framework material and a solvent, the cyclodextrin inclusion compound is prepared by the slightly-soluble contraceptives, beta-cyclodextrin and a solvent, and the mole ratio of the slightly-soluble contraceptives to the beta-cyclodextrin is 1:(1-40); the micro-needle framework material is selected from at least one of dextran, hyaluronic acid and chitosan; the mass ratio of the micro-needle framework material to the cyclodextrin inclusion compound is 1:(0.2-5). The soluble micro-needle has the advantages that the soluble micro-needle is good in mechanical performance and good in percutaneous absorption effect; compared with a traditional transdermal patch, the soluble micro-needle greatly increases the percutaneous penetration efficiency of drugs, has similar effects as oral-taking preparations and avoids drug irritation to gastrointestinal tracts.

The present invention provides novel herbal nano emulsion based formulations comprising a combination of lemon juice and / or rose water as therapeutically active aqueous phase entrapped in oil phase selected from one or more essential oils and process for the preparation of the same in pharmaceutically acceptable dosage forms for topical treatment of acne and other skin disorder like eczema, psoriasis, aging scaring and the like with increased efficacy, improved percutaneous penetration, excellent thermodynamic stability ensuring long shelf life, low skin irritation and reservoir effect that promotes drug localization in the skin enabling controlled delivery of the said therapeutic agents.

The invention provides a compound phosphatide transfer body with high deformability. The compound phosphatide transfer body with high deformability comprises the following components in parts by weight: 0.5-5 parts of a surfactant, 1-10 parts of dipalmitoyl phosphorylcholine and 1-10 parts of dimyristoyl phosphorylcholine, wherein the surfactant is selected from sodium cholate, sodium deoxycholate, Twain and Span; the molar ratio of the dipalmitoyl phosphorylcholine to the dimyristoyl phosphorylcholine is (1: 1)-(1: 6); and the compound phosphatide transfer body with high deformability can be prepared by adopting any method of preparing lipidosome. Compared with the frequently-used granulesten and lecithin transfer bodies in the prior art, the deformability of the provided compound phosphatide transfer body is improved remarkably, the stability of a carrier is also improved remarkably, and the capability of a packaged drug of passing through a skin barrier is finally and remarkably improved, i.e. the percutaneous penetration effect is improved. By applying the transfer body technology to the transdermal drug delivery preparation, the capability of the drug of passing through a horny layer is improved obviously, and the drug effect can be improved obviously.

The present invention provides novel herbal nano emulsion based formulations comprising a combination of lemon juice and / or rose water as therapeutically active aqueous phase entrapped in oil phase selected from one or more essential oils and process for the preparation of the same in pharmaceutically acceptable dosage forms for topical treatment of acne and other skin disorder like eczema, psoriasis, aging scaring and the like with increased efficacy, Improved percutaneous penetration, excellent thermodynamic stability ensuring long shelf life, low skin irritation and reservoir effect that promotes drug localization in the skin enabling controlled delivery of the said therapeutic agents.

The invention discloses a tolterodine gel preparation, which is mainly prepared from free alkali tolterodine, gel matrix, film-forming matrix, organosilicon elastic body, percutaneous penetration accelerators, pH regulators, humectants, and the like. During use, the gel preparation contains the film-forming matrix which can form a flexible film after being dried, and can be externally coated on the thigh, the belly, the upper arm or shoulder, and other parts; flexible and wear-resistant thin film can be rapidly formed in the selected skin region; the gel is prevented from being taken away by the clothes; and meanwhile, the application site is in an unsealed state and has good air permeability. The contained organosilicon elastic body can obviously improve the dispersibility, flexibility, wettability, glossiness, and other performances of the gel system. The prepared gel is smooth, crystal clear and fine, has no foreign body sensation on the skin after use, durable medicament and slow release, good percutaneous absorption effect, convenient use, and improves the patient compliance.

The invention discloses eprinomectin (EPR) emulsion gel. According to the emulsion gel, EPR is prepared into an oil-in-water emulsion to improve the water solubility and effectively improve the dispersion degree and drug-loading capacity of EPR, and the EPR emulsion and gel are mixed to prepare the emulsion gel to further improve the emulsion stability. The EPR emulsion gel can be used for improving the water solubility of EPR and effectively improving the dispersion degree and drug-loading capacity of EPR, and has relatively high stability and excellent adhesive performance. Compared with an EPR suspension, the EPR emulsion gel has the advantage of constantly penetrating skin of a rat and has a relatively high percutaneous penetration rate.

The invention discloses application of a penetration-enhancing composition in percutaneous penetration enhancement of an external preparation. The application comprises adding the penetration-enhancing composition to the external preparation which is a nonsteroidal anti-inflammatory drug; the penetration-enhancing composition contains an organic acid and a penetration enhancer; by mass, the mixture of the penetration-enhancing composition and the external preparation comprises 0.1-5% of the nonsteroidal anti-inflammatory drug, 0.05-10% of the organic acid, and 0.05-30% of the penetration enhancer. In combination with an ion-pairing agent and a common penetration enhancer, the penetration-enhancing composition helps increase the percutaneous penetration quantity of the nonsteroidal anti-inflammatory drug to be increased by 5-10 times and relieve the damage to the skin structure due to the nonsteroidal anti-inflammatory drug.

The invention relates to a crebanine transdermal patch and a preparation method thereof. The crebanine transdermal patch is formed by sequentially overlapping a back lining layer, a medicine-containing adhesive layer and a protective layer, wherein the medicine-containing adhesive layer is prepared from the following components in parts by weight: 0.03 to 0.135 part of crebanine or crebanine hydrochloride, 0.03 to 0.09 part of cross-linking agent, 0.3 to 0.9 part of pressure sensitive adhesive, 0.19 to 0.63 part of plasticizer, 0.1 to 0.3 part of moisturizer, and 0.007 to 0.206 part of percutaneous penetration enhancer. The crebanine transdermal patch has relatively good percutaneous absorption, is more lasting in action time than that of an oral preparation, is more convenient to use than an injection preparation, is good in compliance of patients, and has the characteristics of security, effectiveness, convenience in using, and no irritation and toxicity. Crebanine in the transdermal patch disclosed by the invention is relatively high in cumulative infiltration capacity and can maintain effective blood drug concentration for a longer time, has obvious and lasting antiarrhythmic effect, and overcomes the phenomena that the lasting time of arrhythmia caused by intravenous injection or gastric infusion administration is relatively short and relapse easily occurs.

The invention belongs to the technical field of medical preparations, particularly relates to a ketamine transdermal patch and a preparation method thereof. The preparation method includes the steps:performing decrystallization on ketamine to obtain decrystallization powder; dispersing the decrystallization powder into cholesterol and fatty acid to form dispersion micro-spheres of a micro-storagewarehouse; coating a high-molecular pressure sensitive adhesive with the micro-spheres to obtain the transdermal patch. According to the transdermal patch, a crystallization inhibitor is omitted, ketamine can be effectively quantified, addiction risks are reduced, the transdermal patch is conveniently prepared and used and does not easily diffuse to penetrate cuticles, percutaneous penetration rate is obviously increased, and major depressive disorder (MDD) and / or pain treatment effects are ensured.

The invention relates to a nisoldipine ethosome controlled-released patch and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The nisoldipine ethosome controlled-released patch consists of a back lining, a frame type medicated storage cavern layer and an anti-adhesion layer, and the frame type medicated storage cavern layer contains nisoldipine ethosomes, pressure-sensitive adhesives, penetration enhancer, crosslinking agents, plasticizer and humectants. The ethosomes serve as transdermal drug delivery carriers, percutaneous permeation of the nisoldipine is improved, release of drug is controlled by the frame type pressure-sensitive adhesives, and the nisoldipine transdermal delivery patch is prepared. Compared with a nisoldipine oral preparation, the nisoldipine ethosome controlled-released patch can overcome shortcomings that a first-pass effect of oral delivery is obvious, bioavailability is low, and untoward effects of a digestive tract are obvious. Compared with a common nisoldipine patch, the nisoldipine ethosome controlled-released patch has the advantages that a controlled-released characteristic is good in a percutaneous penetration process, the percutaneous penetration rate of drug is increased for five times at least, stable high blood concentration can be maintained for a long time, relative bioavailability is improved for 4 times almost.

The invention belongs to the field of medicine, and relates to a skin flap infection and avascular necrosis prevention and treatment transdermal preparation and a preparation method thereof. The skin flap infection and avascular necrosis prevention and treatment transdermal preparation contains azithromycin (AZM), amlodipine (AB), low molecular weight heparin (LMWH-Na), a hydrogel matrix and other components. According to the present invention, the rational formula and the optimized preparation method are adopted to preferably select the optimal concentrations of the three main drugs, such that the problem that the three main drugs compete the kin penetration channel and the macromolecule LMWH-Na is not easily subjected to percutaneous penetration are solved; and with the prepared transdermal preparation, the disadvantages that the drugs of the oral administration or intravenous injection and other systemic administration, and intubation intermittent administration under the skin flap or one time injection and other topical administrations difficultly reach the ischemic local skin flap while the plasma concentration is relatively high so as to easily produce systemic adverse reactions and the like are overcome, the stable effective drug concentration at the local skin flap can be maintained, the skin flap survival area can be improved, the systemic effect is low, and the defects of the existing treatment method in the field of skin flap infection and avascular necrosis are overcome.