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Ultrasonic percutaneous permeating device, ultrasonic percutaneous permeating kit, and ultrasonic percutaneous permeating method

a technology of ultrasonic waves and permeating devices, applied in chiropractic devices, medical science, physical therapy, etc., can solve the problem of not being able to say that the above-mentioned irradiation conditions of ultrasonic waves are appropria

Inactive Publication Date: 2005-02-24
MATSUSHITA ELECTRIC WORKS LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0006] An objective of the present invention is to provide an ultrasonic percutaneous penetration device which allows a medicine to effectively penetrate the skin, fatty tissue and muscle tissue safely.
[0033] As described above, the process in which the medicine is made in contact with the skin is carried out prior to application of the ultrasonic waves; therefore, the medicine is not susceptible to limitations in the shape or the like required to transmit ultrasonic waves to the skin. Therefore, the medicine to be penetrated can be used as a packed product and the like.

Problems solved by technology

However, when action of ultrasonic waves to a target portion such as skin and fat and characteristics of the ultrasonic waves are taken into consideration, it cannot be said that the above-mentioned irradiation conditions of ultrasonic wave are appropriate.

Method used

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  • Ultrasonic percutaneous permeating device, ultrasonic percutaneous permeating kit, and ultrasonic percutaneous permeating method
  • Ultrasonic percutaneous permeating device, ultrasonic percutaneous permeating kit, and ultrasonic percutaneous permeating method
  • Ultrasonic percutaneous permeating device, ultrasonic percutaneous permeating kit, and ultrasonic percutaneous permeating method

Examples

Experimental program
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Effect test

specific example 1

[0065] An ultrasonic percutaneous penetration device A, as shown in FIG. 1, was used. With respect to a medicine 1, a whitening agent was used. With respect to the whitening agent, 1 cc (1 cm3) of gel-state aqueous solution to which carboxy methylcellulose (CMC) containing 3% of vitamin C derivatives (magnesium ascorbyl phosphate) was added was used. Here, the gel-state aqueous solution to which carboxy methylcellulose (CMC) containing no vitamin C derivatives was added corresponds to an ultrasonic wave transmission medium 25.

[0066] The above-mentioned whitening agent was applied to a skin surface 2a, and ultrasonic waves were then applied to this skin surface 2a of an organism 2 from the irradiation unit 4 of the ultrasonic percutaneous device A through the whitening agent so that the medicine 1 was allowed to penetrate the skin (epidermis basal lamina). At this time, the irradiation conditions of the ultrasonic waves were set as follows: frequency: 5 MHz, irradiation power to the...

specific example 2

[0069] First, as shown in FIG. 2, the ultrasonic wave transmission medium 25 was applied to a skin surface 2a in the same manner as described above, and ultrasonic waves were applied to the skin surface 2a by using the same ultrasonic percutaneous penetration device A as specific example 1 through the ultrasonic wave transmission medium 25, and allowed to penetrate the skin surface 2a. The same irradiation conditions as those of specific example 1 were used. Next, after the irradiation with ultrasonic waves, the ultrasonic wave transmission medium 25 was removed from the skin surface 2a, and this was allowed to stand still for 30 minutes. Thereafter, the same whitening agent as that of specific example 1 was applied to the skin surface 2a at the portion subjected to the irradiation with ultrasonic waves.

[0070] With respect to this specific example 2, the quantity of penetration of vitamin C (quantity of ascorbic acids per 1 g of skin) after the application of the whitening agent wa...

specific example 3

[0072] After skin lotion (medicine 1) containing 5% of vitamin C derivatives (magnesium ascorbyl phosphate) had been applied to the entire portion of the face with cotton, ultrasonic waves were applied to only the half portion of the face through a gel-state ultrasonic wave transmission medium 25 without containing any whitening component in the same manner as described above for 10 minutes. At this time, the irradiation conditions of the ultrasonic waves were set as follows: frequency: 1 MHz, irradiation power to the skin surface 2a: 0.5 W / cm2, probe area of the irradiation unit 4: 4.52 cm2, and an output method for ultrasonic waves (power): continuous output (duty ratio: 100%).

[0073] These operations were carried out almost every day, and the results obtained 2 to 3 months later are shown in FIG. 7. FIG. 7 compares the change in the color of pigmentation between the half of face (medicine+ultrasonic waves) to which both of the medicine 1 and ultrasonic waves were applied and the ...

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Abstract

Upon allowing a medicine 1 containing an active ingredient to penetrate an organism 2 from a skin surface 2a, this ultrasonic percutaneous penetration device A allows vibration of ultrasonic waves to penetrate the organism from the skin surface. This device is provided with an irradiation unit 4 that applies ultrasonic waves having a frequency of not less than 0.5 MHz from skin 2a or a surface capable of contacting the medicine, and a control unit 3 that controls irradiation conditions of the irradiation unit.

Description

TECHNICAL FIELD [0001] The present invention relates to an ultrasonic percutaneous penetration device which allows a medicine containing an active ingredient to penetrate a portion of the organism percutaneously by using ultrasonic vibration. BACKGROUND ART [0002] Conventionally, a DDS (drug delivery system, percutaneous medicine delivery system) has been developed as a technique which allows a medicine to penetrate percutaneously so that an active ingredient of the medicine is applied to the skin and circulatory system, and an iontophoresis method which allows penetration by using electricity has developed considerably as a method of the chemical administration. Moreover, techniques using ultrasonic vibration have been gradually developed, and, for example, Japanese Laid-Open Patent Publication No. 52-115591 has proposed a method in which a medicine is allowed to penetrate a skin through irradiation of ultrasonic waves having a frequency of 1 MHz for the treatment of herpes, and Ja...

Claims

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Application Information

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IPC IPC(8): A61B17/00A61B17/54A61M35/00A61M37/00
CPCA61B17/54A61B2017/00747A61M2037/0007A61M35/003A61M37/0092A61B2017/00765A61M37/00
Inventor MATSUMURA, YUKOSATO, YASUHIRO
Owner MATSUSHITA ELECTRIC WORKS LTD
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