Propranolol hydrochloride gel for treating infant superficial hemangioma
The technology of propranolol hydrochloride gel and propranolol hydrochloride, which is applied in the field of medicine, can solve the problems of unclear treatment mechanism, apoptosis of vascular endothelial cells, etc., and achieves avoiding adverse reactions, convenient administration and simple preparation. Effect
Active Publication Date: 2013-01-16
XIANGYA HOSPITAL CENT SOUTH UNIV
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Problems solved by technology
Although its therapeutic mechanism is not yet clear, it may be related to reducing the release of NO to constrict blood vessels, blocking the signaling pathway of angiogenesis, or inducing apoptosis of vascular endothelial cells, etc.
Method used
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Experimental program
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Effect test
Embodiment 1
[0055] Prepare the gel according to the following prescription (calculated as 100g): PPL·HCl 3g, hydroxypropyl methylcellulose 3g, geraniol 5g, propylene glycol 10g, Tween-601.0g, ethyl paraben 1.0g, the balance is Distilled water.
Embodiment 2
[0057] The gel was prepared according to the following prescription (calculated as 100g): PPL·HCl 6g, hydroxypropyl methylcellulose 3g, geraniol 5g, propylene glycol 10g, Tween-601.0g, ethyl paraben 1.0g, the balance is Distilled water.
Embodiment 3
[0059] The gel was prepared according to the following prescription (calculated as 100g): PPL·HCl 10g, sodium carboxymethyl cellulose 3g, geraniol 5g, propylene glycol 10g, Tween-601.0g, ethyl paraben 1.0g, the balance is distilled water .
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The invention belongs to the technical field of medicines, and provides a propranolol hydrochloride (PPL.HCL) gel which can be externally used for treating infant superficial hemangioma. The propranolol hydrochloride gel is mainly prepared from propranolol hydrochloride, gel matrix, a percutaneous penetration enhancer, a preservative, a humectant and the like. By using the propranolol hydrochloride gel, adverse reactions such as decreased heart rate, cyanosis, airway hyperresponsiveness, shortage of granular leukocytes, diarrhoea, sleep change and blood sugar reduction caused by orally taking propranolol by hemangioma patients can be reduced and even avoided, and the problems that oral dosage is not easy to control, infants inconveniently take medicines and the like are solved.
Description
Technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a gel for external use using propranolol hydrochloride (PPL·HCl) as an active ingredient. Background technique [0002] Infantile hemangioma (IH) is a kind of congenital dysplasia that occurs during the embryonic blood vessel formation. It is more common at birth or shortly after birth. It is the most common benign tumor in infants and young children. The incidence rate in newborns is 2% to 3%, the incidence rate in children under 1 year is about 10%, and the incidence rate in preterm infants or low birth weight newborns can be as high as 22% to 30%. It usually occurs on the head, neck, trunk and other body surface parts, which affects the appearance, and is often adjacent to important organs, affecting physiological functions or even life-threatening. Early treatment should be actively carried out to control growth and promote regression. There are many traditional treat...
Claims
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IPC IPC(8): A61K9/06A61K31/138A61K47/10A61K47/08A61P35/00
Inventor 陈翔丁劲松张江林
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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