Propranolol hydrochloride gel for treating infant superficial hemangioma
A technology of propranolol hydrochloride gel and hemangioma, applied in the field of medicine, can solve the problems of vascular endothelial cell apoptosis and unclear treatment mechanism, and achieve the effects of avoiding adverse reactions, good air permeability and low cost
Active Publication Date: 2014-03-05
XIANGYA HOSPITAL CENT SOUTH UNIV
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Problems solved by technology
Although its therapeutic mechanism is not yet clear, it may be related to reducing the release of NO to constrict blood vessels, blocking the signaling pathway of angiogenesis, or inducing apoptosis of vascular endothelial cells, etc.
Method used
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Effect test
Embodiment 1
[0055] The gel was prepared according to the following prescription (according to 100g): PPL·HCl 3g, hydroxypropyl methylcellulose 3g, geraniol 5g, propylene glycol 10g, Tween-60 1.0g, ethylparaben 1.0g, the balance was distilled water.
Embodiment 2
[0057] The gel was prepared according to the following prescription (according to 100g): PPL·HCl 6g, hydroxypropyl methylcellulose 3g, geraniol 5g, propylene glycol 10g, Tween-601.0g, ethylparaben 1.0g, the balance was distilled water.
Embodiment 3
[0059] Prepare the gel according to the following prescription (according to 100g): 10g of PPL·HCl, 3g of sodium carboxymethylcellulose, 5g of geraniol, 10g of propylene glycol, 1.0g of Tween-60, 1.0g of ethylparaben, and distilled water as the rest .
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The invention belongs to the technical field of medicines, and provides a propranolol hydrochloride (PPL.HCL) gel which can be externally used for treating infant superficial hemangioma. The propranolol hydrochloride gel is mainly prepared from propranolol hydrochloride, gel matrix, a percutaneous penetration enhancer, a preservative, a humectant and the like. By using the propranolol hydrochloride gel, adverse reactions such as decreased heart rate, cyanosis, airway hyperresponsiveness, shortage of granular leukocytes, diarrhoea, sleep change and blood sugar reduction caused by orally taking propranolol by hemangioma patients can be reduced and even avoided, and the problems that oral dosage is not easy to control, infants inconveniently take medicines and the like are solved.
Description
technical field [0001] The invention belongs to the technical field of medicine, in particular to an external gel with propranolol hydrochloride (PPL·HCl) as an active ingredient. Background technique [0002] Infantile hemangioma (IH) is a congenital dysplasia that occurs during the formation of blood vessels in the embryonic period. It is more common at birth or shortly after birth. It is the most common benign tumor in infants and young children. The incidence rate in newborns is 2%~3%, the incidence rate in children under 1 year old is about 10%, and the incidence rate in premature infants or low birth weight neonates can be as high as 22%~30%. It tends to occur in the head, neck, trunk and other body surface parts, which affects the appearance, and is often adjacent to important organs, affecting physiological functions and even life-threatening. Early treatment should be actively carried out to control growth and promote regression. There are many traditional treatmen...
Claims
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IPC IPC(8): A61K9/06A61K31/138A61K47/10A61K47/08A61P35/00
Inventor 陈翔丁劲松张江林
Owner XIANGYA HOSPITAL CENT SOUTH UNIV