Mouse spinal tuberculosis model construction platform

A spinal tuberculosis and mouse technology, applied in the field of mouse spinal tuberculosis model building platform, can solve the problems of difficulty in building spinal tuberculosis models, low infection rate, model failure, etc., achieve long-term effective tuberculosis concentration, avoid in vitro coagulation, The effect of easy injection operation

Pending Publication Date: 2018-08-21
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Abstract
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  • Claims
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AI Technical Summary

Problems solved by technology

However, the vertebral bodies, paraspinal compensatory spaces, and vertebral body attachments are small in mice, and the damage to the bone cortex by Mycobacterium tuberculosis is a long-term accumulation process, so it is relatively difficult to construct a spinal tuberculosis model
Traditional paravertebral implants or vertebral implants often make the pus liquid unable to reach a long-term effective concentration at the injection site, which easily leads to failure of modeling
Liesbeth et al. improved the modeling method by infecting mice for 10 months with the nasal drop method of pus bacteria. After systemic infection of the mice, MRI signal changes could be found in the mouse spine, but no obvious destructive foci or granulomatous changes were seen. , this method has a low infection rate, takes a long time to build a model and is not typical, it is difficult to replicate the model, and it is not easy to promote

Method used

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  • Mouse spinal tuberculosis model construction platform
  • Mouse spinal tuberculosis model construction platform
  • Mouse spinal tuberculosis model construction platform

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Embodiment Construction

[0018] The present invention will be described in further detail below in conjunction with the accompanying drawings and specific embodiments.

[0019] Figure 1 to Figure 4 An embodiment of the present invention is shown. The mouse spinal tuberculosis model construction platform of this embodiment includes an injection platform 1 and a cooling box 3 for cooling the syringe 2. The injection platform 1 is provided with a cooling box for limiting mouse activity. The limiting part 11 of the cooling box 3 is provided with a positioning part 31 for placing the syringe 2 horizontally.

[0020] The inventors found that direct injection of the pus solution alone may lead to problems such as rapid absorption of the pus fluid into the blood, leakage of the pus fluid to other areas in the body, or overflow of the pus fluid from the body surface. In order to allow the pus fluid to better remain in the injection site and maintain an effective concentration, we add Matrigel Matrix (or Matr...

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Abstract

The invention discloses a mouse spinal tuberculosis model construction platform comprising an injection table and a cooling tank for cooling a syringe, wherein the injection table is provided with a limiting portion for limiting the movement of a mouse, and the cooling tank is provided with a positioning portion for horizontally placing the syringe. The mouse spinal tuberculosis model constructionplatform has the advantages of convenience and accuracy in operation, good reliability, high mold formation rate and short mold forming time and the like.

Description

technical field [0001] The invention relates to a medical experimental device, in particular to a platform for constructing a mouse spinal tuberculosis model. Background technique [0002] There are as many as 9.6 million tuberculosis patients in the world, and my country accounts for about 10%. The incidence and prevalence of tuberculosis rank third in the world. The spine is a common site of extrapulmonary tuberculosis. Globally, spinal tuberculosis accounts for about 1-5% of all tuberculosis cases and accounts for 50% of bone and joint tuberculosis. In China, especially in remote areas, spinal tuberculosis is still a common and frequently-occurring disease. In addition, the onset is hidden and early diagnosis is difficult, and its disability rate is very high. The diagnosis and treatment of spinal tuberculosis still face severe challenges due to the rising rate of HIV infection and the increase of tuberculosis drug resistance. The development of spinal tuberculosis is c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61D3/00A61D7/00
CPCA61D3/00A61D7/00
Inventor 高琪乐何丹张宏其
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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