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In-situ gel for subcutaneous injection for treating breast cancer and its use

A subcutaneous injection, in situ gel technology, applied in the field of medicine, can solve the problem of less research and other problems

Active Publication Date: 2018-09-25
JINING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are few studies on natural alkaloid anti-tumor synergistic drugs

Method used

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  • In-situ gel for subcutaneous injection for treating breast cancer and its use
  • In-situ gel for subcutaneous injection for treating breast cancer and its use
  • In-situ gel for subcutaneous injection for treating breast cancer and its use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 Preparation of in situ gel for subcutaneous injection

[0025] Ascarin 69g

[0026] Soy Lecithin 210g

[0027] Medium Chain Triglycerides 45 g

[0028] 90% ethanol 45 g

[0029] Take the prescribed amount of ascarin and 90% ethanol, mix and stir evenly, add the prescribed amount of soybean lecithin and medium-chain triglycerides, stir at 800 rpm for 1 hour, and then sterilize and pack.

Embodiment 2

[0030] Example 2 Preparation of in situ gel for subcutaneous injection

[0031] Ascarin 67g

[0032] Soy Lecithin 210g

[0033] Medium Chain Triglycerides 45 g

[0034] 90% ethanol 45 g

[0035] Take the prescribed amount of ascarin and 90% ethanol, mix and stir evenly, add the prescribed amount of soybean lecithin and medium-chain triglycerides, stir at 800 rpm for 1 hour, and then sterilize and pack.

Embodiment 3

[0036] Example 3 Preparation of in situ gel for subcutaneous injection

[0037] Ascarin 69g

[0038] Zingiberine 19 g

[0039] Soy Lecithin 210g

[0040] Medium Chain Triglycerides 45 g

[0041] 90% ethanol 45 g

[0042] Take the prescribed amount of ascarin, argonin and 90% ethanol, mix and stir evenly, add the prescribed amount of soybean lecithin and medium-chain triglycerides, stir at 800 rpm for 1 hour, and then sterilize and pack.

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PUM

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Abstract

The invention belongs to the field of medicine and particularly relates to in-situ gel for subcutaneous injection for treating breast cancer and its pharmaceutical use. The active ingredient of the in-situ gel for subcutaneous injection is astragalin or a composition of astragalin and laurolitsine in the weight ratio of the astragalin to laurolitsine is 63 to 69: 19. The excipients of the in-situgel for subcutaneous injection comprise soy lecithin, medium chain triglyceride and 90% ethanol. The in-situ gel for subcutaneous injection for treating breast cancer exerts a sustained release effectby a gel drug reservoir formed by subcutaneous injection, has a good therapeutic effect on estrogen-dependent breast cancer and can reduce toxic or side effects caused by systemic administration suchas oral administration or intravenous injection.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to an in-situ gel for subcutaneous injection for treating breast cancer and its application. Background technique [0002] Cancer is a major disease that seriously threatens human life. According to the epidemiological statistics from 2016 to 2017, the top five cancers in male cancers in my country are non-small cell lung cancer, gastric cancer / cardia cancer, colorectal cancer, esophageal cancer, and small cell lung cancer. The top five cancers in women are breast cancer, colorectal cancer, small cell lung cancer, cervical cancer, and gastric / cardiac cancer. In other words, breast cancer is the most important malignant tumor that threatens women's life and health. [0003] Breast cancer is mainly produced by malignant changes in the mammary ductal epithelium. The main clinical manifestations are mammary gland swelling and pain, mass, lymph node enlargement under the armpit and...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/24A61K47/14A61K31/7048A61K31/473A61P35/00
CPCA61K9/0024A61K9/06A61K31/473A61K31/7048A61K47/14A61K47/24A61P35/00A61K2300/00
Inventor 魏开芳周金辉张春燕上官国强孔庆胜
Owner JINING MEDICAL UNIV
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