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A fingerprint of the fat-soluble components of Danqi Soft Capsules and its detection method and application

A detection method and fingerprint technology, applied in the field of medicine, to achieve the effect of good stability and controllability

Active Publication Date: 2021-02-09
BEIJING RED SUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this study mainly focused on the polar parts of Danqi Soft Capsules, and the research on the low-polarity fat-soluble components of this type of drug has not yet involved

Method used

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  • A fingerprint of the fat-soluble components of Danqi Soft Capsules and its detection method and application
  • A fingerprint of the fat-soluble components of Danqi Soft Capsules and its detection method and application
  • A fingerprint of the fat-soluble components of Danqi Soft Capsules and its detection method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Establishment and determination of fingerprints of Danqi soft capsules

[0032] (1) Instrument

[0033] TRACE 1310 / TSQ 8000 gas chromatography-mass spectrometer (Thermo, USA); BS210S electronic analytical balance (Beijing Sartorius Balance Co., Ltd.).

[0034] (2) Drugs and reagents

[0035] Danqi Soft Capsules (Beijing Great Wall Pharmaceutical Factory, 50 capsules / bottle, 0.6g per capsule, batch numbers 13110105, 13110215, 14080101, 14080102, 14090101, 14090102, 14100101, 14100102, 14110101, 14110102, 14110113; All were purchased from Anguo Pharmaceutical Market and identified as authentic by Tang Shihuan, an associate researcher at the Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences. B21707-20160325, GC≥98%) were purchased from Shanghai Yuanye Biotechnology Co., Ltd., and the rest of the reagents were of analytical grade.

[0036] (3) Experimental conditions

[0037] Gas chromatography conditions: DB-5ms capillary column ...

Embodiment 2

[0051] Example 2 Identification of common chromatographic peaks in the fat-soluble components of Danqi soft capsule GC-MS fingerprint

[0052] Through the GC-MS analysis of the samples of Danshen and Panax notoginseng prescriptions, the common chromatographic peaks were assigned according to the retention time of the chromatographic peaks and the information of mass spectrum. At the same time, the total ion current chromatogram of the fat-soluble components of Danqi Soft Capsules was analyzed and processed, and compared with the standard mass spectrum provided by the NIST mass spectral library, the qualitative results of each chromatographic peak were initially obtained. A total of 49 peaks were separated and identified. For 38 compounds, the relative percentage content of each compound was obtained by the normalized integral method, and the theoretical calculation formula is as follows:

[0053]

[0054] [In the formula, Pi represents the relative percentage (%) of the i-t...

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Abstract

The invention belongs to the technical field of medicine, and particularly relates to a Danqi soft capsule fat-soluble component fingerprint, a detection method and applications thereof. According tothe present invention, the Danqi soft capsule fat-soluble component fingerprint is established by using a GC-MS method, the 13 common peaks are determined, the assignments of each common peak are clarified, and the area of the common chromatographic peaks accounts for 74.71% of the total peak area; and the Danqi soft capsule fat-soluble component fingerprint provides the scientific basis for the quality control of the preparation and the further pharmacodynamic research.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a fingerprint of a fat-soluble component of Danqi soft capsule, a detection method and application thereof. Background technique [0002] Traditional Chinese medicine is a precious heritage of the Chinese nation and the world civilization. Its curative effect has been verified by clinical practice for thousands of years, and it has played an indelible role in the reproduction of the Chinese nation. Traditional Chinese medicine preparations that are mutually restricted and coordinated by "jun, minister, assistant, and envoy" emphasize that they play a role as a whole, and most of them are not aimed at a certain target, nor are they simple additions of several components. The detection of a single component alone reduces the The accuracy and specificity of identification cannot represent the overall efficacy of traditional Chinese medicine preparations, nor can it refl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 林德良杨健
Owner BEIJING RED SUN PHARMA
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