Parameter estimation method, intelligent device and storage medium of bioimpedance cole equation

A bio-impedance and parameter estimation technology, applied in the field of clinical medicine, can solve problems such as poor anti-interference ability, unclear initial guess value and constraint range, and achieve good robustness, avoid noise risk, and strong anti-interference ability

Active Publication Date: 2021-07-30
MAIDEAN MEDICAL EQUIP SHENZHEN
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Problems solved by technology

[0012] In view of this, a method for estimating parameters of the bioimpedance Cole equation, an intelligent device and a storage medium provided by the present invention can solve the problem that the initial guess value and constraint range of the parameters of the bioimpedance Cole equation in the prior art are not clear, which leads to Poor anti-interference ability, especially under the influence of severe noise, the anti-interference ability is even worse

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  • Parameter estimation method, intelligent device and storage medium of bioimpedance cole equation
  • Parameter estimation method, intelligent device and storage medium of bioimpedance cole equation
  • Parameter estimation method, intelligent device and storage medium of bioimpedance cole equation

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[0053] Below, the present invention will be further described in conjunction with the accompanying drawings and specific implementation methods. It should be noted that, under the premise of not conflicting, the various embodiments described below or the technical features can be combined arbitrarily to form new embodiments. .

[0054] refer to figure 1 , figure 1 It is a flowchart of an embodiment of a method for estimating parameters of a bioimpedance Cole equation in the present invention.

[0055] It should be noted that the bioimpedance Cole equation is where, where, Z(ω) is the impedance, R 0 is the resistance at DC, R ∞ is the resistance at infinite frequency, ω is the angular frequency, τ is the time constant related to the cell membrane, and α is the distribution of the time constant. The above formula is called the Cole equation.

[0056] In step S101, the real part and the imaginary part of the impedance value are calculated according to the amplitude and phas...

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Abstract

The invention discloses a method for estimating parameters of a biological impedance Cole equation, an intelligent device and a storage medium. The method includes: calculating the real part and the imaginary part of the impedance value according to the amplitude and phase value of the potential difference measured at different frequencies; determining the initial guess value and the constraint range of each parameter according to the real part and the imaginary part of the impedance value; The fitting parameters and the fitting impedance value are determined according to the initial guess value and the constraint range of each parameter; the best fitting parameter value is determined according to the threshold of the error sum of squares of the fitting impedance value and the measured value. A method for estimating the parameters of the Cole equation of biological impedance, smart devices and storage media simultaneously use the real part and the imaginary part of the impedance to solve the numerical solution of the equation system, estimate the initial guess value and the constraint range for NLLS fitting, and further adopt avoidance The measure of noise risk has good robustness and strong anti-interference ability. In the case of severe noise, it can also accurately fit and estimate the parameters of the Cole equation, so that more accurate ECW and TBW values ​​can be obtained.

Description

technical field [0001] The invention relates to the field of clinical medicine, in particular to a method for estimating parameters of a bioimpedance Cole equation, an intelligent device and a storage medium. Background technique [0002] Fluid overload is associated with increased morbidity and mortality in patients with chronic kidney disease, acute kidney injury, or heart failure and critical illness. Therefore, the determination of extracellular fluid has important clinical significance. Bioimpedance is a reliable, non-invasive technique that uses the electrical properties of human tissue to measure extracellular fluid and total body water. [0003] Cells are the basic structure of biological tissues, composed of extracellular fluid, intracellular fluid, and cell membrane. When biological tissues are in the low frequency region (below 1MHz), the electrical properties of extracellular fluid and intracellular fluid are close to resistance, while the cell membrane can be ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/053
CPCA61B5/0537A61B5/4881
Inventor 李燕青
Owner MAIDEAN MEDICAL EQUIP SHENZHEN
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