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Diagnostic or predictor of relapsing remitting multiple sclerosis

A multiple sclerosis, factor technology, used in disease diagnosis, measurement devices, biological tests, etc.

Active Publication Date: 2019-04-02
DIGNITY HEALTH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there is currently no known method for predicting or diagnosing whether a patient with multiple sclerosis is about to experience a relapse
If a patient does experience a relapse, there is no known method for predicting or diagnosing the likelihood of recovery from a relapse with standard symptomatic treatment

Method used

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  • Diagnostic or predictor of relapsing remitting multiple sclerosis
  • Diagnostic or predictor of relapsing remitting multiple sclerosis
  • Diagnostic or predictor of relapsing remitting multiple sclerosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Factor VIII activity

[0059] Factor VIII is expressed in the blood-brain barrier. It is a marker for brain endothelial cells and for the integrity of the blood-brain barrier. Previous studies have shown that thrombin is activated in multiple sclerosis plaques and that thrombin inhibition may be useful for recovery from MS exacerbations in animal models. This process also involves cell signaling, direct fibrin deposition effects, and microglial effects. In one embodiment, it is disclosed herein that elevated Factor VIII activity may be indicative of an appropriate subgroup of MS patients who may benefit from thrombin inhibition during recovery from a multiple sclerosis exacerbation.

[0060] In some embodiments, Factor VIII activity is not consistently high in individuals with a high Expanded Disability Status Scale (EDSS). In one embodiment, there may be fluctuations that parallel the patient's disease process. Factor VIII activity greater than or equal to 160 is a...

Embodiment 2

[0064] Association of factor VIII activity with exacerbation

[0065] The inventors have determined that increased Factor VIII activity over time correlates with MS exacerbation. In one embodiment, the invention provides that increased activity is associated with slow-to-recover relapses of multiple sclerosis. In one embodiment, increased activity is associated with exacerbation of spinal multiple sclerosis. In another embodiment, the patient is diagnosed with elevated Factor VIII activity and is treated with Or steroid treatment, factor VIII activity returned to normal.

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Abstract

Provided herein is a method of detecting or predicting a relapse of multiple sclerosis in an individual afflicted with a form of multiple sclerosis, comprising: (a) providing a blood sample of the individual; (b) testing the blood sample to determine a protein activity or protein level, wherein the protein is Factor VIII, von Willebrand factor, or Protein C; and (c) detecting or predicting a relapse of multiple sclerosis in the individual if the protein activity or protein level is elevated compared to the protein activity or protein level in an individual not afflicted with the form of multiple sclerosis and patients' own baseline values. Also provided herein is a method of treating an individual afflicted with multiple sclerosis, who is experiencing a relapse or predicted to experience arelapse, comprising treating the individual by administering a dose of a steroid or anti-coagulation compound effective to alleviate the symptom of multiple sclerosis.

Description

technical field [0001] The disclosure of this application is in the field of medicine and pharmacy, more specifically in the field of multiple sclerosis. Background technique [0002] Multiple sclerosis, or MS, is an autoimmune disease that affects the central nervous system. Multiple sclerosis is a disease of unknown etiology with a prolonged course involving many remissions and relapses. Some people may live with multiple sclerosis for years without suffering severe symptoms. Others may be quickly incapacitated. It is unclear why the course of the disease varies so widely. However, most people with multiple sclerosis experience periodic relapses, also called flare-ups, exacerbations, or seizures. These can be mild or severe. Symptoms can include muscle weakness, visual disturbances, balance problems, memory loss and / or loss of bowel or bladder control. [0003] Currently, the drugs used in MS drug treatment can be divided into two groups: drugs used to treat symptoms...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P25/00A61P25/28G01N33/48G01N33/53G01N33/564G01N33/68
CPCG01N33/6896G01N33/86G01N2333/755G01N2800/285G01N2800/54A61P25/00A61P25/28A61K31/727A61K31/573
Inventor D·罗伊
Owner DIGNITY HEALTH
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