Expansion and use of expanded nk cell fractions
A cell proliferation and cell technology, applied in the field of treatment of hematological malignancies, can solve problems such as the difficulty of designing NK amplification and treatment plans
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[0093] The present invention relates to methods of expanding a natural killer (NK) cell fraction for implantation into a subject while maintaining or enhancing cellular function in vitro and / or in vivo. In one embodiment, culturing NK cells in vitro with nicotinamide and / or other moieties of nicotinamide and NK cell growth factors promotes said production of NK cell populations for use as a therapeutic in vitro expanded NK cell preparation. The NK cell preparation comprises an expanded functional NK cell population having parameters suitable for infusion into a subject (e.g. NK cells and a reduced CD3+ T cell strongly amplified partially together). In particular in this regard, the present invention can be used to provide transplantable NK cell fractions and protocols for their use, which can be applied to cell transplantation and infusion for the treatment of cancer and other diseases. Non-limiting applications may include: allogeneic adoptive immunotherapy and combination i...
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