15 results about "Cells transplant" patented technology

The invention relates to the technical field of nerve injury repair, in particular to a spinal cord injury repair system based on ordered collagen scaffold carried cell transplantation combined with electroacupuncture stimulation application. The invention provides a spinal cord injury repairing system, which comprises a biological material support transplanting module, a cell inoculating module and a spinal cord injury repairing module, and the electro-acupuncture stimulation module is used for applying electro-acupuncture stimulation to acupuncture points after the biological material stent inoculated with the cells is transplanted to the spinal cord injury part. According to the system, electroacupuncture stimulation and biomaterial stent transplantation cells are combined for application, the microenvironment can be remarkably improved, survival, differentiation and function integration of the transplantation cells can be promoted, meanwhile, muscle atrophy and joint degeneration are relieved, an innovative treatment system is provided for spinal cord injury, and the system has high clinical feasibility and is worthy of popularization and application. Good application prospects are realized in the field of spinal cord injury repair.

Novel methods are disclosed for treating patients with Parkinson's disease and other primary and secondary parkinsonian disorders by improving cell engraftment. Treating patients with antihyperlipidemic drugs and / or CSF-1R antagonists before, during, and / or after transplantation of DA neurons improves cell viability, engraftment, proliferation, migration, or differentiation of the administered DA neurons. Methods are disclosed for pre-treating patients to improve engraftment of administered cells. Methods are disclosed for pre-treating patients to improve engraftment of administered progenitor cells.

Nanoparticles, methods, and kits are provided for supplying nutrients and other therapeutic agents to transplanted cells. Nutrient deprivation is a significant factor which contributes to poor outcome of many cell transplants because cells receive insufficient nutrients until they are able to establish a functional microcirculation to support their metabolic and physiological needs after transplantation. Nanoparticles are provided for use in supplying nutrients and other therapeutic agents to transplanted cells to improve cell survival. Such nanoparticles can be used to supply nutrients and other factors to transplanted cells until the transplanted cells are able to develop a new microcirculation.

The application discloses a kind of fibroblast growth factor 2 and mesenchymal cell co-loaded freeze-dried collagen support and its preparation method and application, belong to the technical field of biomedical materials, by adding sulfated polysaccharide to collagen solution, it is formed freeze-dried collagen support containing sulfated polysaccharide by vacuum freeze-drying, it is combined with fibroblast growth factor 2 incubation, obtain the freeze-dried collagen support of loading fibroblast growth factor 2, again mesenchymal cell is inoculated in the freeze-dried collagen support of loading fibroblast growth factor 2, and the freeze-dried collagen support of fibroblast growth factor 2 and mesenchymal cell co-loading is prepared.The support obtained by the application can efficiently combine fibroblast growth factor 2, support the adhesion growth of mesenchymal cell simultaneously, promote mesenchymal cell to migrate to the inside of support, realize the uniform distribution of cell in support, and can promote angiogenesis, provide new and efficient carrier for cell transplantation treatment.

The invention discloses autologous fat transplantation equipment for increasing the survival rate of fat cells, and relates to the technical field of fat cell transplantation. Comprising an adipocyte transplantation processing mechanism, the adipocyte transplantation processing mechanism comprises a cell transplantation box, and a control panel is installed on the surface of the cell transplantation box; the device can conveniently extract transplanted and extracted fat cells, is beneficial to efficiently treating the transplanted fat cells, improves the fat cell transplantation and extraction effect, reduces the probability of errors caused by manual extraction of the fat cells by medical staff, can ensure that the fat cells are transplanted and extracted in a closed and sterile environment, and improves the survival rate of the fat cells. The fat cell transplantation and extraction device is simple in structure and convenient to use, the survival rate of fat cell transplantation and extraction is increased, medical articles for fat cell extraction can be stored, medical staff can conveniently operate in the fat cell transplantation and extraction work, the fat cell transplantation efficiency of the medical staff is improved, and convenience is provided for the staff.

Provided herein are methods and systems of transplant cells and growing an ectopic tissue in a lymph node of a subject. In certain embodiments, the methods and systems provided herein enable minimally invasive cell transplantation to treat patients in need thereof. In certain embodiments, the methods and systems provided herein include the use of ultrasound endoscopy.

The present disclosure relates to a catechol group- or pyrogallol group-functionalized biocompatible polymer hydrogel patch having excellent biocompatibility and tissue adhesion, and uses for drug delivery, cell transplantation and tissue regeneration using the same. The biocompatible polymer hydrogel patch functionalized with the catechol group or pyrogallol group of the present disclosure has remarkably excellent mechanical properties and tissue adhesion compared with a solution-based bulk hydrogel. Therefore, it can load cells and a drug in vivo for a long time and also safely and efficiently deliver the cells and the drug to a target site.

An application of using n-butylidenephthalide (BP) in dopamine precursor cell transplantation treatment, including using n-butylidenephthalide (BP) to improve the treatment efficacy of dopamine precursor cell transplantation treatment and using n-butylidenephthalide (BP) and dopamine precursor cells treated by n-butylidenephthalide (BP) in dopamine precursor cell transplantation treatment. The foregoing application is particularly related to using n-butylidenephthalide (BP) to improve the efficacy of dopamine precursor cell transplantation treatment in treating Parkinson's disease.

Disclosed is a composition for supporting survival and differentiation of neural precursor cells (NPCs) grafted into a neurological injury or disease site, the composition comprising: (a) a gel forming molecule; and (b) a chemokine receptor type 5 (CCR5) antagonist. Also disclosed is a method of treating a neurological injury or disease of a subject, comprising (a) mixing NPCs with the composition as disclosed herein; and (b) administering a mixture of the NPCs and the composition into a neurological injury or disease site of the subject, to thereby support survival and differentiation of the NPCs. Also disclosed is use of a mixture of NPCs and the composition as disclosed herein in the manufacture of a medicament for treating a neurological injury or disease of a subject, wherein the mixture is to be administered into a neurological injury or disease site of the subject, to thereby support survival and differentiation of the NPCs. Further disclosed is a kit for use in supporting survival and differentiation of NPCs grafted into a neurological injury or disease site, the kit comprising: (a) the composition as disclosed herein; (b) artificial cerebral spinal fluid (a-CSF); (c) CaCl2; and (d) thrombin.

Disclosed is a composition for supporting survival and differentiation of neural precursor cells (NPCs) grafted into a neurological injury or disease site, the composition comprising: (a) a gel forming molecule; and (b) a chemokine receptor type 5 (CCR5) antagonist. Also disclosed is a method of treating a neurological injury or disease of a subject, comprising (a) mixing NPCs with the composition as disclosed herein; and (b) administering a mixture of the NPCs and the composition into a neurological injury or disease site of the subject, to thereby support survival and differentiation of the NPCs. Also disclosed is use of a mixture of NPCs and the composition as disclosed herein in the manufacture of a medicament for treating a neurological injury or disease of a subject, wherein the mixture is to be administered into a neurological injury or disease site of the subject, to thereby support survival and differentiation of the NPCs. Further disclosed is a kit for use in supporting survival and differentiation of NPCs grafted into a neurological injury or disease site, the kit comprising: (a) the composition as disclosed herein; (b) artificial cerebral spinal fluid (a-CSF); (c) CaCl2; and (d) thrombin.

The present invention relates to a method for isolating dopaminergic neurons and to a pharmaceutical composition for the treatment of Parkinson's disease containing dopaminergic neurons isolated by said method. The method for isolating dopaminergic neurons comprises a step for isolating dopaminergic neurons that are positive for trophoblastic glycoprotein (TPBG), such that the dopaminergic neurons isolated by this method exhibit greater cellular efficacy upon transplantation and greater transplant safety, thus enabling their effective use in cell transplantation for the treatment of Parkinson's disease.

The health-care preparation comprises the surfactant provided by the invention and an active ingredient prepared into a solid, a liquid or an emulsion. The invention provides a preparation of a health care product, such as prescription medicine and non-prescription medicine. Mineral, herbal and / or vitamin supplements; medicaments applied in hospitals, clinics, doctor offices and nightseeing care places; vaccines, tissues, organs and cell grafts and / or substitutes and / or infusion agents; and wound care formulations including topical ointments, lotions, cleaners, wipes, bandages, and dressings. The active may be included in the formulation as a solute, solvent, particle, or oil immiscible component of the formulation. The active may be included in a tablet, capsule, tincture, liquid or emulsion. Healthcare formulations of the present invention include formulations suitable for oral, topical and / or injection administration.

Compositions and methods are provided for transplantation of cells to the body, utilizing a thermosensitive polymer that forms a gel when introduced onto tissue or into a cavity of the tissue, such as the eye.

The application provides a traditional Chinese medicine preparation for treating esophageal cancer and a preparation method thereof, and relates to the technical field of traditional Chinese medicine pharmacy. The traditional Chinese medicine preparation is composed of Wilingxian, Shijianchuan, Kelp, Caenotus, Zhongjie wind, Lotus leaf peduncle, Chutoucao, Shashen, Jiuxiangchong, Shiqiti, Huangyaozi, Jiluo, and Luhongfang. The application verifies the anti-esophageal cancer effect and safety of the traditional Chinese medicine preparation through in-vitro and in-vivo experiments. The in-vitro experiment shows that the traditional Chinese medicine preparation can significantly reduce the TNF-alpha, IL-1beta and IL-8 levels in the supernatant of esophageal cancer cells Eca-109, and plays an anti-tumor role by regulating the inflammatory microenvironment. The in-vivo experiment shows that the traditional Chinese medicine preparation can inhibit the growth of esophageal cancer EC9706 cell transplanted tumors in nude mice, remodel the immune balance of the organism by bidirectional regulation of immune cell subgroups, and enhance the anti-tumor immunity. Meanwhile, the traditional Chinese medicine preparation does not cause liver and kidney damage to the nude mice at an effective dose, and provides a new scheme with safety and effectiveness for the clinical treatment of esophageal cancer.

The present invention relates to a conditioning regimen for the transplant of a cell to a subject, optionally wherein the cell is a hematopoietic stem / progenitor cells (HSPC), a CAR cell or a platelet. The invention also relates to methods for the prevention or treatment of a disease or condition in a subject by administration of a cell transplant, wherein said administration comprises the conditioning regimen of the invention.