Application of novel gastric cancer marker gene circPTPDC1

A marker gene, gastric cancer technology, applied in the field of tumor molecular biology, can solve the problems of poor screening compliance

Active Publication Date: 2019-04-23
江苏万成生物医学研究院有限公司
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  • Abstract
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Problems solved by technology

[0005] In order to solve the above problems, the present invention discloses the application of a new gastric cancer marker gene circPTPDC1, aiming at the poor compliance of the target population with endoscopic screening for gastric cancer and the fact that most of the clinically diagnosed gastric cancer patien...

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  • Application of novel gastric cancer marker gene circPTPDC1
  • Application of novel gastric cancer marker gene circPTPDC1
  • Application of novel gastric cancer marker gene circPTPDC1

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Embodiment Construction

[0027] The present invention will be further explained below in conjunction with the accompanying drawings and specific embodiments. It should be understood that the following specific embodiments are only used to illustrate the present invention and are not intended to limit the scope of the present invention.

[0028] The invention discloses the application of a new gastric cancer marker gene circPTPDC1, the nucleotide sequence of the circPTPDC1 molecular marker is SEQ ID NO.1, and the circPTPDC1 is used as a marker for the diagnosis and prognosis of gastric cancer. The following experimental methods are specific examples, and the experimental results are as follows Figure 1 to Figure 5 shown.

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Abstract

The invention discloses the application of a novel gastric cancer marker gene circPTPDC1, and relates to the discovery, detection and application of a circPTPDC1 molecular marker. A specific detectingprimer which is used for quantifying PCR in real time is designed and synthesized. The marker gene is provided aiming at the problems that the compliance of target crowds on gastric cancer endoscopicscreening is poor and gastric cancer patients are mostly and clinically diagnosed according to middle and late current situations, an ideal molecular early warning signal is found in the cancerationprocess of the gastric cancer, endoscopic inspection is targetedly conducted, athological diagnosis is conducted to relieve the pain of a patient, and over-treatment is conducted to save medical resources. According to the application, it is discovered that blood circPTPDC1 can be adopted as a marker of lymph node metastasis and monitoring prognosis of the gastric patients.

Description

technical field [0001] The invention relates to the field of tumor molecular biology, in particular to the application of a novel gastric cancer marker gene circPTPDC1. Background technique [0002] At present, gastric cancer still ranks third in cancer-related deaths worldwide and is one of the major health burdens of society. Gastric cancer is the second most prevalent cancer and the second leading cause of cancer death in China, with an estimated 679,100 new cases and 498,000 deaths in 2015. Despite advances in surgical techniques and combined chemotherapy regimens, the 5-year overall survival of gastric cancer is still below 30% in most countries because of the lack of early diagnostic markers for gastric cancer. Therefore, it is necessary to carefully explore gastric cancer-related molecular features and develop reasonable methods for early detection of gastric cancer. [0003] Circular RNAs (circRNAs), thought to arise from non-canonical splicing of linear pre-mRNAs,...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886C12Q1/6851C12N15/113C12N15/11
CPCC12N15/113C12Q1/6851C12Q1/6886C12N2310/532C12Q2600/178C12Q2600/158C12Q2600/112C12Q2600/118C12Q2531/113C12Q2545/101
Inventor 康宁朱桂芳曹秀峰
Owner 江苏万成生物医学研究院有限公司
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