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A kind of eye skin care composition containing hirudin and hyaluronic acid

A technology of skin care composition and hyaluronate, which is applied in skin care preparations, cosmetic preparations, pharmaceutical formulations, etc., can solve the problems of low utilization rate, high amount of hirudin added, and limited skin absorption, etc., to reduce Dosage, effect of improving microcirculation and reducing blood viscosity

Active Publication Date: 2021-12-10
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the prior art, the patent application with the application number 201711371054.9 discloses a hirudin moisturizing and repairing essence, in which 1-5% hirudin is added, and sodium hyaluronate is used as a moisturizing agent. 3-20%, the molecular weight of sodium hyaluronate is not subdivided, the product functions are transdermal absorption, improving blood circulation, nourishing the skin, promoting penetration and carrying, etc. The efficacy evaluation in the examples is limited to soothing, toning and moisturizing 2 types; the patent application with the application number 201710482500.7 discloses a Dendrobium candidum eye skin care product and its preparation method, which mainly uses ingredients such as Dendrobium candidum extract to remove fat particles, dark circles, bags under the eyes, relieve skin fatigue around the eyes, and effectively Relieve fine lines and dry lines around the eyes; the patent application No. 201810826848.8 discloses a repairing eye cream, the content of recombinant hirudin is added to 24-28 parts, the amount of hirudin added is too high, the skin absorption is limited, and the utilization rate is low
[0006] However, in the current research, the composition containing recombinant hirudin and hyaluronic acid substances synergistically acting on eye skin problems has not been reported

Method used

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  • A kind of eye skin care composition containing hirudin and hyaluronic acid
  • A kind of eye skin care composition containing hirudin and hyaluronic acid
  • A kind of eye skin care composition containing hirudin and hyaluronic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 Preparation and screening of eye skin care combination

[0020] 1 Preparation of eye serum

[0021] Prepare the eye skin care composition containing recombinant hirudin and sodium hyaluronate after mixing evenly according to the weight ratio in the following tables 1-1 and 1-2, as the C phase in the eye essence:

[0022] Table 1-1 Formula of eye skin care composition

[0023]

[0024] Table 1-2 Formula of eye skin care composition

[0025] .

[0026] Table 2 Formula of eye essence

[0027] .

[0028] Weigh each component according to the weight percentage in above-mentioned table 2, prepare eye essence according to the following method:

[0029] (1) Mix phase A evenly, add appropriate amount of water, stir and dissolve at 50°C to obtain mixed phase 1;

[0030] (2) Add phase B to mixed phase 1, stir and dissolve at 50°C to obtain mixed phase 2;

[0031] (3) Add phase C and phase D into the mixed phase 2 in sequence below 40°C, stir to dissolve com...

Embodiment 2

[0046] Embodiment 2 Preparation and effect of eye skin care combination

[0047] According to the weight ratio in the following Table 5, after mixing evenly, an eye skin care composition containing recombinant hirudin and sodium hyaluronate was prepared, and as the C phase in the eye essence, different preparations were prepared by referring to the method of Example 1. Eye essence, the sample numbers are shown in Table 5.

[0048] Formulation of table 5 eye skin care composition and its content in eye essence

[0049] .

[0050] 1. Improve the effect of dark circles and eye puffiness

[0051] Volunteer screening, evaluation methods and smearing methods are the same as in Example 1, and the results of 28 days are evaluated.

[0052] Table 6 Improvement effect of different samples on dark circles and eye puffiness (results after 28 days)

[0053]

[0054] It can be seen from the data in the above table that the composition of recombinant hirudin and hyaluronic acid has ...

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Abstract

The invention provides an eye skin care composition containing hirudin and hyaluronic substances, which is composed of hirudin and hyaluronic substances, and the mass ratio of hirudin and hyaluronic substances is 1:1 -20. The molecular weight of described hyaluronic acid substance is 1.5×10 5 Da‑1.8×10 6 Da. The eye skin care composition can be used in cosmetics, and the content in cosmetics is 0.01-10%. In the present invention, hyaluronic acid substances with specific molecular weight have synergistic effect on hirudin. The combination of the two substances can solve the problems of dark circles, edema, eye bags, fine lines and dry lines and fat particles in the eye skin.

Description

technical field [0001] The invention belongs to the field of cosmetics, in particular to an eye skin care composition containing hirudin and hyaluronic acid substances. Background technique [0002] The eye skin is the thinnest part of the human skin, only about 1 / 4 of the thickness of the facial skin, so it is vulnerable to damage from the external environment such as ultraviolet rays; at the same time, the eye skin is rich in connective tissue, rich in capillaries and nerve endings , the walls of these capillaries are very thin and have a certain degree of permeability, so they are easy to congest and cause eye edema due to water accumulation; in addition, the eye skin lacks the distribution of sebaceous glands and sweat glands, and the oil that can be supplied is relatively small, and the skin has no natural Moisturizing ability, so it is more prone to dryness and lack of moisture than other parts of the skin, resulting in dry lines and fine lines on the skin around the e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/64A61K8/73A61Q19/00
Inventor 陈衍玲王玉玲郭学平范馨仪徐松堂刘建建
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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