Water-in-oil and oil-in-water type emulsion aerosol and preparation method thereof
An oil-in-water-in-oil and aerosol technology, which is applied in the direction of aerosol delivery, emulsion delivery, anti-inflammatory agents, etc., can solve problems such as complex effects, achieve local skin irritation, be easy to carry and use, reduce The effect of skin allergies
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Embodiment 1~3
[0028] The preparation of embodiment 1~3 O / W type emulsion
[0029] (1) Crush 17-25 parts of Shengchuan Aconitum, 17-25 parts of Shengcaowu, 17-25 parts of Araceae, 8-15 parts of cinnamon, 8-15 parts of ground beetle and 1-1.5 parts of centipede into coarse powder, After immersing in ethanol solution overnight, reflux extraction, and collect the extract; add 10 times the amount of water to the medicinal residue, raise the temperature to 60°C, conduct ultrasonic extraction for 5 hours, and separate the extract and medicinal residue; combine the ethanol extract and water extract, concentrate, Dry to obtain extract powder; stir and dissolve extract powder with ethanol, propylene glycol and water mixed solvent, and add polyoxypropylene stearate (Atlas G-3608) and polyoxyethylene monostearate (Myrj 49) for compound emulsification agent to form an aqueous phase;
[0030] (2) Mix 8-15 parts of black snake, 17-25 parts of Qianghuo, 17-25 parts of Fangfeng, 17-25 parts of mustard seed...
Embodiment 4~5
[0038] The preparation of embodiment 4~5 O / W / O type emulsion
[0039] (1) Mix and grind 7-15 parts of borneol and 3-8 parts of menthol, add 7-15 parts of turpentine, dissolve with 5 times the amount of vegetable oil, and add sorbitan monooleate (Span 80 ), forming the outer oil phase;
[0040](2) Heat the outer oil phase to 90°C, add the O / W emulsion obtained in Example 2 while stirring the outer oil phase at 1000prm, continue to stir and cool to room temperature, and obtain an O / W / O emulsion;
[0041] (3) Pack the O / W / O emulsion and propellant in step (2) in a pressurized airtight container to prepare an O / W / O emulsion aerosol.
[0042]
[0043] As shown in Table 2, when Span 80: Vegetable oil = 1-2:20, and the volume ratio of inner oil phase: water phase: outer oil phase is in the range of 2:6:9-11, it can form an average particle size of 290-420nm O / W / O droplets, in which the coated O / W droplets are mostly 1 to 3. When the content of Span 80 is too low or the ratio of...
Embodiment 6
[0044] Example 6 Local irritation test
[0045] Group 1: Example 5 aerosol; Group 2: Zhenjiang plaster; Blank group 1: Blank aerosol; Blank group 2: Blank plaster
[0046] The backs of 6 guinea pigs were depilated respectively, and divided into two groups (n=3). The guinea pigs of group A were sprayed with the aerosol of Example 5 of Group 1 on the left side (pressed twice), and the right side was sprayed with the blank air of Group 1. Spray (press twice); Zhenjiang plaster (4cm*4cm) of group 2 was pasted on the left side of the back of group B guinea pigs, and blank plaster (4cm*4cm) of blank group 2 was pasted on the right side of the back, and on the 3rd, 5th, and 7th days Repeat the administration, remove the plaster on the 8th day, wash the administration area with warm water, and observe the skin condition of each group.
[0047] The backs of the 3 guinea pigs in the group 1 sprayed with aerosol and the 3 guinea pigs in the blank group 1 did not appear red and swollen, ...
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