Water-in-oil and oil-in-water type emulsion aerosol and preparation method thereof

An oil-in-water-in-oil and aerosol technology, which is applied in the direction of aerosol delivery, emulsion delivery, anti-inflammatory agents, etc., can solve problems such as complex effects, achieve local skin irritation, be easy to carry and use, reduce The effect of skin allergies

Active Publication Date: 2020-12-11
JIANGSU 707 NATURAL PHARMA
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are many components in traditional Chinese medicine patches and their functions are complex. How to combine t

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Water-in-oil and oil-in-water type emulsion aerosol and preparation method thereof
  • Water-in-oil and oil-in-water type emulsion aerosol and preparation method thereof
  • Water-in-oil and oil-in-water type emulsion aerosol and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～3

[0028] The preparation of embodiment 1~3 O / W type emulsion

[0029] (1) Crush 17-25 parts of Shengchuan Aconitum, 17-25 parts of Shengcaowu, 17-25 parts of Araceae, 8-15 parts of cinnamon, 8-15 parts of ground beetle and 1-1.5 parts of centipede into coarse powder, After immersing in ethanol solution overnight, reflux extraction, and collect the extract; add 10 times the amount of water to the medicinal residue, raise the temperature to 60°C, conduct ultrasonic extraction for 5 hours, and separate the extract and medicinal residue; combine the ethanol extract and water extract, concentrate, Dry to obtain extract powder; stir and dissolve extract powder with ethanol, propylene glycol and water mixed solvent, and add polyoxypropylene stearate (Atlas G-3608) and polyoxyethylene monostearate (Myrj 49) for compound emulsification agent to form an aqueous phase;

[0030] (2) Mix 8-15 parts of black snake, 17-25 parts of Qianghuo, 17-25 parts of Fangfeng, 17-25 parts of mustard seed...

Embodiment 4～5

[0038] The preparation of embodiment 4~5 O / W / O type emulsion

[0039] (1) Mix and grind 7-15 parts of borneol and 3-8 parts of menthol, add 7-15 parts of turpentine, dissolve with 5 times the amount of vegetable oil, and add sorbitan monooleate (Span 80 ), forming the outer oil phase;

[0040](2) Heat the outer oil phase to 90°C, add the O / W emulsion obtained in Example 2 while stirring the outer oil phase at 1000prm, continue to stir and cool to room temperature, and obtain an O / W / O emulsion;

[0041] (3) Pack the O / W / O emulsion and propellant in step (2) in a pressurized airtight container to prepare an O / W / O emulsion aerosol.

[0042]

[0043] As shown in Table 2, when Span 80: Vegetable oil = 1-2:20, and the volume ratio of inner oil phase: water phase: outer oil phase is in the range of 2:6:9-11, it can form an average particle size of 290-420nm O / W / O droplets, in which the coated O / W droplets are mostly 1 to 3. When the content of Span 80 is too low or the ratio of...

Embodiment 6

[0044] Example 6 Local irritation test

[0045] Group 1: Example 5 aerosol; Group 2: Zhenjiang plaster; Blank group 1: Blank aerosol; Blank group 2: Blank plaster

[0046] The backs of 6 guinea pigs were depilated respectively, and divided into two groups (n=3). The guinea pigs of group A were sprayed with the aerosol of Example 5 of Group 1 on the left side (pressed twice), and the right side was sprayed with the blank air of Group 1. Spray (press twice); Zhenjiang plaster (4cm*4cm) of group 2 was pasted on the left side of the back of group B guinea pigs, and blank plaster (4cm*4cm) of blank group 2 was pasted on the right side of the back, and on the 3rd, 5th, and 7th days Repeat the administration, remove the plaster on the 8th day, wash the administration area with warm water, and observe the skin condition of each group.

[0047] The backs of the 3 guinea pigs in the group 1 sprayed with aerosol and the 3 guinea pigs in the blank group 1 did not appear red and swollen, ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
The average particle sizeaaaaaaaaaa
The average particle sizeaaaaaaaaaa
The average particle sizeaaaaaaaaaa
Login to view more

Abstract

The invention discloses a water-in-oil and oil-in-water type emulsion aerosol and a preparation method thereof. The water-in-oil and oil-in-water type emulsion aerosol comprises water-in-oil and oil-in-water emulsion and a propellant; the ratio of an inner oil phase to a water phase to an outer oil phase in the water-in-oil and oil-in-water emulsion is 2: (6-7): (9-11) (v/v); the propellant accounts for 10-20% of the emulsion mass; and the inner oil phase comprises an auxiliary drug, the water phase comprises a main drug, and the outer oil phase comprises a transdermal enhancer. According to the water-in-oil and oil-in-water type emulsion aerosol, the water-in-oil and oil-in-water emulsion is prepared through a two-step emulsification method; the average particle size of the obtained intermediate O/W type emulsion is 180-220 nm, the average particle size of the obtained O/W/O type emulsion is 290-420 nm, and then the O/W/O type emulsion and the propellant are packaged in a pressurizedclosed container to obtain the aerosol. According to the aerosol, all the components are reasonably distributed in an emulsion structure, the structure is kept stable, transdermal absorption is promoted, and medication stimulation is reduced.

Description

technical field [0001] The invention relates to a traditional Chinese medicine aerosol, in particular to an oil-in-water-in-oil type emulsion aerosol and a preparation method thereof. Background technique [0002] Zhenjiang plaster is a kind of traditional Chinese medicine patch mainly used for the treatment of muscle and bone pain and bruises. However, as a traditional dosage form, traditional Chinese medicine patches have the disadvantages of being more irritating to the skin, causing skin allergies, difficult to clean the patch, and polluting clothes. Therefore, it is necessary to improve the dosage form. The aerosol for external use has the advantages of less dosage, accurate dosage, convenient use, less irritation, local positioning and quick effect, and can be used as an improved dosage form of traditional Chinese medicine patch for local external use. However, there are many components in traditional Chinese medicine patches and their functions are complex. How to co...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K36/902A61K9/12A61K9/113A61K47/44A61P29/00A61K31/045A61K35/36A61K35/583A61K35/64
CPCA61K35/583A61K36/237A61K36/238A61K36/31A61K36/232A61K36/81A61K35/36A61K36/56A61K36/17A61K36/47A61K36/286A61K36/902A61K36/736A61K35/64A61K36/714A61K36/8884A61K36/54A61K35/648A61K31/045A61K9/12A61K9/113A61K9/0014A61K47/44A61P29/00A61K2236/331A61K2236/333A61K2236/35A61K2300/00
Inventor 成吉民陈夏娟
Owner JIANGSU 707 NATURAL PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap